Compare Imitrex vs. Cafergot

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Imitrex (Sumatriptan)

Prescription only
Treats migraine headaches.

Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.

5.3/ 7 average rating with 31 reviewsforImitrex
Treats migraine headaches.

Cafergot (ergotamine / caffeine) can treat migraines, but you're more likely to have side effects.

Upsides
  • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
  • A combination of forms can be used if symptoms do not improve.
  • The nasal spray and injectable forms work very quickly.
  • It's generally safe to use if you are pregnant.
  • Comes in a generic form, so it can be pretty cheap.
  • Cafergot (ergotamine / caffeine) works better than other medicines if your migraines usually last more than 2 days or if you have more frequent migraines.
Downsides
  • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
  • Does not prevent migraine headaches; it only treats them once they start.
  • Must wait 1 hour before using second injection.
  • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
  • Need to have your blood pressure checked often, especially if you're pregnant.
  • Cafergot (ergotamine / caffeine) can't stop migraines from happening. They can only treat them.
  • Cafergot (ergotamine / caffeine) can only be used for migraines. It doesn't work for other types of headaches.
  • Smoking or using products that contain nicotine can make Cafergot (ergotamine / caffeine) less effective.
Used for
Dosage forms
  • Pill
  • Injection
  • Nasal spray
  • Pill
  • Suppository
Price
Lowest price near you
$12.4
Find instant savings
Lowest price near you
$653.26
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
31 
74%
think this treatment is worth it
68%
think this treatment works well
19%
think this treatment is a hassle

Have you used Imitrex (Sumatriptan)?

Leave a review
Not enough review data.Leave a review
Side effects
6possible side effects
  • Pain and other pressure sensations
    6%
  • Atypical sensations
    5%
  • Paresthesia (all types)
    3%
  • Sensation warm/cold
    3%
  • Pain - location specified
    2%
  • Malaise/fatigue
    2%
See more detailed side effects
The Cafergot (ergotamine / caffeine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Tightening of blood vessels (myocardial angina, ischemia, or infarction)

    History of heart problems

    ...and 5 more risk factors

  • Stroke

    History of heart problems

    ...and 5 more risk factors

  • Serotonin syndrome

    Patients taking SSRIs and SNRIs

  • High blood pressure

    History of high blood pressure

  • Seizures

    History of seizures

See more detailed risks and warnings
  • Heart and circulation problems

    Overdosing Cafergot (ergotamine / caffeine)

    ...and 1 more risk factors

  • Dependency and withdrawal

    Taking Cafergot (ergotamine / caffeine) regularly for months

See more detailed risks and warnings