Compare Imitrex vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Imitrex
(sumatriptan)

Depacon
(valproate, valproic acid, or divalproex)

Treats migraine headaches. Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.
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Best available price for 1 (9 tablets of 100mg) dose pack of sumatriptan
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.29Imitrex
Reviews for Imitrex (sumatriptan)
74%
of people (All ages) say Imitrex (sumatriptan) is worth it
68%
say it works well
19%
say it's a big hassle
Have you used Imitrex (sumatriptan)?
Worth itNot sureNot worth it
Reviews for Depacon (valproate, valproic acid, or divalproex)
46%
-28% worse vs. Imitrex (sumatriptan)
40%
-28% worse vs. Imitrex (sumatriptan)
27%
-8% worse vs. Imitrex (sumatriptan)
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it
Side effects
ImitrexDepakote
  • Pain and other pressure sensations 2%
  • Atypical sensations 1%
  • Paresthesia (all types) 1%
  • Sensation warm/cold 1%
  • Pain - location specified 1%
  • Malaise/fatigue 2%
  • Chest - pain/tightness/pressure and/or heaviness 1%
  • Neck/throat/jaw - pain/ tightness/pressure 2%
  • Other - pressure/tightness/ heaviness 1%
  • Vertigo 2%
More Imitrex side effects »
  • Nausea 7%
  • Drowsiness 7%
  • Dizziness 8%
  • Vomiting 9%
  • Accidental injury 6%
  • Muscle weakness 3%
  • Abdominal pain 1%
  • Indigestion 1%
  • Any side effect 4%
  • Rash 3%
More Depakote side effects »
How it works
ImitrexDepakote
Imitrex (Sumatriptan) is a triptan medication that treats migraine headaches. It releases serotonin, which lowers the inflammation that causes headaches.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.
Type of medication
ImitrexDepakote
Prescription only
Prescription only
Available as
ImitrexDepakote
  • Pill
  • Injection
  • Nasal spray
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Used for
ImitrexDepakote
Risk factors for serious side effects
ImitrexDepakote
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
Detailed Imitrex (sumatriptan) risks & warnings »
  • Children under age 2
  • History of metabolic disorders
  • History of depression
  • People also taking Topamax
Detailed Depacon (valproate, valproic acid, or divalproex) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
ImitrexDepakote
No food related info.
  • Take with food to avoid upset stomach.
Kidneys and liver
ImitrexDepakote
No kidneys and liver related info.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
Sleep
ImitrexDepakote
  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
No sleep related info.
Weight
ImitrexDepakote
No weight related info.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • May cause hair loss and weight gain.
Upsides and benefits
ImitrexDepakote
  • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
  • A combination of forms can be used if symptoms do not improve.
  • The nasal spray and injectable forms work very quickly.
  • It's generally safe to use if you are pregnant.
  • Comes in a generic form, so it can be pretty cheap.
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
Downsides and risks
ImitrexDepakote
  • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
  • Does not prevent migraine headaches; it only treats them once they start.
  • Must wait 1 hour before using second injection.
  • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
  • Need to have your blood pressure checked often, especially if you're pregnant.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
Tips from our pharmacists for people taking the medication
ImitrexDepakote
  • Take it as soon as your headache starts.
  • If you use the nasal spray, be sure to blow your nose before using it.
  • If you use the patch, put it on a dry area free of scars, tattoos, or other cuts and scrapes. Be sure to press the button to activate it.
  • If you use the injection, you can use a second injection if you still have a headache after an hour. If you have symptoms 2 hours after the injection, switch to the pill version.
  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
  • Lie down in a dark room after taking Imitrex (Sumatriptan) to help ease the pain.
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Take with food to avoid upset stomach.
  • May cause hair loss and weight gain.
  • Different versions of Depakote have different dosing. Be careful.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes 3 to 4 weeks to feel full effects on mood.
Learn more
More about ImitrexSide effectsReviews & ratingsFDA package insert
Have you used Imitrex (sumatriptan)?
Worth itNot sureNot worth it
More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it