Compare Imitrex vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Imitrex
(Sumatriptan)

Depacon
(Valproate, Valproic Acid, Or Divalproex)

Treats migraine headaches. Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.538461538461538Imitrex
Reviews for Imitrex (Sumatriptan)
77%
of people say Imitrex (Sumatriptan) is worth it
73%
say it works well
15%
say it's a big hassle
Reviews for Depacon (Valproate, Valproic Acid, Or Divalproex)
46%
31% vs. Imitrex (Sumatriptan)
39%
34% vs. Imitrex (Sumatriptan)
27%
12% vs. Imitrex (Sumatriptan)
Side effects
ImitrexDepakote
  • Pain and other pressure sensations 4%
  • Paresthesia (all types) 3%
  • Atypical sensations 2%
  • Chest - pain/tightness/pressure and/or heaviness 1%
  • Pain - location specified 1%
  • Sensation warm/cold 1%
  • Other - pressure/tightness/ heaviness 1%
More Imitrex side effects »
  • Nausea 34%
  • Muscle weakness 20%
  • Vomiting 20%
  • Abdominal pain 17%
  • Dizziness 12%
  • Headache 10%
  • Double vision 7%
  • Involuntary eye movement 7%
  • Lack of muscle coordination 7%
  • Accidental injury 6%
More Depakote side effects »
How it works
ImitrexDepakote
Imitrex (Sumatriptan) is a triptan medication that treats migraine headaches. It releases serotonin, which lowers the inflammation that causes headaches.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.
Type of medication
ImitrexDepakote
Antimigraine
Triptan
Prescription only
AnticonvulsantPrescription only
Available as
ImitrexDepakote
  • Pill
  • Injection
  • Nasal spray
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Used for (click to learn more)
ImitrexDepakote
Risk factors for serious side effects
ImitrexDepakote
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
  • Smoking
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
  • Smoking
    • Patients taking SSRIs and SNRIs
    • History of high blood pressure
    • History of seizures
    Detailed Imitrex (Sumatriptan) risks & warnings »
      • Children under age 2
      • History of metabolic disorders
        • History of depression
          • History of metabolic disorders
          • People also taking Topamax
          • People also taking Topamax
            • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
            Detailed Depacon (Valproate, Valproic Acid, Or Divalproex) risks & warnings »
            Pregnancy category
            ImitrexDepakote
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            DFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            Alcohol
            No specific alcohol-related info.No specific alcohol-related info.
            Food
            No specific food-related info.
            • Take with food to avoid upset stomach.
            Kidneys and liver
            No specific kidneys and liver-related info.No specific kidneys and liver-related info.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
            No specific sleep-related info.
            Weight
            No specific weight-related info.
            • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
            • May cause hair loss and weight gain.
            Upsides and benefits
            ImitrexDepakote
            • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
            • A combination of forms can be used if symptoms do not improve.
            • The nasal spray and injectable forms work very quickly.
            • It's generally safe to use if you are pregnant.
            • Comes in a generic form, so it can be pretty cheap.
            • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
            • One of the first-line options to stabilize mood for people with bipolar disorder.
            • Helpful in preventing frequent migraine headaches.
            Downsides and risks
            ImitrexDepakote
            • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
            • Does not prevent migraine headaches; it only treats them once they start.
            • Must wait 1 hour before using second injection.
            • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
            • Need to have your blood pressure checked often, especially if you're pregnant.
            • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
            • Can cause liver damage, so it's probably not safe if you already have liver problems.
            • Not safe to use if you're pregnant.
            • Requires routine blood tests to see how the medicine is affecting your body.
            Tips from our pharmacists for people taking the medication
            ImitrexDepakote
            • Take it as soon as your headache starts.
            • If you use the nasal spray, be sure to blow your nose before using it.
            • If you use the patch, put it on a dry area free of scars, tattoos, or other cuts and scrapes. Be sure to press the button to activate it.
            • If you use the injection, you can use a second injection if you still have a headache after an hour. If you have symptoms 2 hours after the injection, switch to the pill version.
            • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
            • Lie down in a dark room after taking Imitrex (Sumatriptan) to help ease the pain.
            • For the first week, avoid activities that require you to be alert.
            • Don't use if pregnant.
            • Requires routine blood tests.
            • Take with food to avoid upset stomach.
            • May cause hair loss and weight gain.
            • Different versions of Depakote have different dosing. Be careful.
            • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
            • Takes 3 to 4 weeks to feel full effects on mood.
            Learn more
            More about ImitrexSide effectsReviews & ratingsAlternativesFDA package insert
            More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert