Compare Imitrex vs. ergotamine

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Treats migraine headaches. Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.Treats migraine headaches. Ergomar (ergotamine) has more side effects than other medicines used to treat migraines.
Reviews & ratings
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Filter group. All currently selected
Reviews for Imitrex
of people (All ages) say Imitrex is worth it
say it works well
say it's a big hassle
Have you used Imitrex (sumatriptan)?
Worth itNot sureNot worth it

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Have you used Ergomar (ergotamine)?
Worth itNot sureNot worth it
Side effects
  • Pain and other pressure sensations 2%
  • Atypical sensations 1%
  • Paresthesia (all types) 1%
  • Sensation warm/cold 1%
  • Pain - location specified 1%
  • Malaise/fatigue 2%
  • Chest - pain/tightness/pressure and/or heaviness 1%
  • Neck/throat/jaw - pain/ tightness/pressure 2%
  • Other - pressure/tightness/ heaviness 1%
  • Vertigo 2%
More Imitrex side effects »

The ergotamine FDA package insert doesn’t have numbers about how common side effects are.

More about ergotamine side effects »
How it works
Imitrex (Sumatriptan) is a triptan medication that treats migraine headaches. It releases serotonin, which lowers the inflammation that causes headaches.Ergomar (ergotamine) is an ergot alkaloid. It tightens the blood vessels in your brain to relieve the pain of your headaches.
Type of medication
Prescription onlyPrescription only
Available as
  • Pill
  • Injection
  • Nasal spray
  • Dissolving pill
Used for
Risk factors for serious side effects
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
Detailed Imitrex (sumatriptan) risks & warnings »
  • Macrolide antibiotics
  • Protease inhibitors
  • Taking Ergomar (ergotamine) more than the recommended amount daily or weekly
  • Taking Ergomar (ergotamine) regularly for months
Detailed Ergomar (ergotamine) risks & warnings »

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
No sleep related info.
Upsides and benefits
  • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
  • A combination of forms can be used if symptoms do not improve.
  • The nasal spray and injectable forms work very quickly.
  • It's generally safe to use if you are pregnant.
  • Comes in a generic form, so it can be pretty cheap.
  • Ergomar (ergotamine) works better than other medicines if your migraines last more than 2 days or if you have more frequent migraines.
Downsides and risks
  • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
  • Does not prevent migraine headaches; it only treats them once they start.
  • Must wait 1 hour before using second injection.
  • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
  • Need to have your blood pressure checked often, especially if you're pregnant.
  • Harmful to the fetus so avoid if you're pregnant or think you may be pregnant.
  • Doesn't prevent migraines from happening. It can only relieve them.
  • Excessive use can be dangerous and result in rebound headaches. Talk to your doctor if your headaches are worse and occurring more frequently.
  • May not be right for you if you have high blood pressure or had a heart attack.
Tips from our pharmacists for people taking the medication
  • Take it as soon as your headache starts.
  • If you use the nasal spray, be sure to blow your nose before using it.
  • If you use the patch, put it on a dry area free of scars, tattoos, or other cuts and scrapes. Be sure to press the button to activate it.
  • If you use the injection, you can use a second injection if you still have a headache after an hour. If you have symptoms 2 hours after the injection, switch to the pill version.
  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
  • Lie down in a dark room after taking Imitrex (Sumatriptan) to help ease the pain.
  • Avoid if you're pregnant or think you may be pregnant since it can harm the fetus.
  • Take as soon as you feel the migraine coming on.
  • You may be more sensitive to cold since Ergomar (ergotamine) affects the circulation of your blood. Dress warmly.
  • Don't use Ergomar (ergotamine) excessively. The most you can take is 3 tablets per day or 5 tablets per week.
  • Don't use with triptans if you're taking Ergomar (ergotamine).
  • Talk to your doctor if you have heart disease or blood vessel problems before starting Ergomar (ergotamine).
Learn more
More about ImitrexSide effectsReviews & ratingsFDA package insert
Have you used Imitrex (sumatriptan)?
Worth itNot sureNot worth it
More about ergotamineSide effectsAlternativesFDA package insert
Have you used Ergomar (ergotamine)?
Worth itNot sureNot worth it