Compare Imitrex vs. Onzetra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Imitrex (Sumatriptan)

Prescription only

Onzetra (sumatriptan)

Prescription only
Treats migraine headaches.

Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.

5.3/ 7 average rating with 31 reviewsforImitrex
Treats migraine headaches.

Onzetra (sumatriptan) is the only medicine that's available in a breath-powered nose powder to treat migraines. However, it can be expensive compared to other medicines.

Upsides
  • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
  • A combination of forms can be used if symptoms do not improve.
  • The nasal spray and injectable forms work very quickly.
  • It's generally safe to use if you are pregnant.
  • Comes in a generic form, so it can be pretty cheap.
  • Compared to pills, Onzetra (sumatriptan) is better absorbed in the body and good if it's hard to take pills.
  • Onzetra (sumatriptan) is a first choice medicine to treat migraines.
  • There is a copay program available that can make Onzetra (sumatriptan) cheaper.
Downsides
  • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
  • Does not prevent migraine headaches; it only treats them once they start.
  • Must wait 1 hour before using second injection.
  • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
  • Need to have your blood pressure checked often, especially if you're pregnant.
  • It can be very expensive. There are other forms of this same medicine that are much cheaper, including a nose spray.
  • You have to use two nosepieces to get the full dose of Onzetra (sumatriptan), which can be hard to remember.
  • Onzetra (sumatriptan) is only available in one strength.
Used for
Dosage forms
  • Pill
  • Injection
  • Nasal spray
  • Nasal powder
Price
Lowest price near you
$12.4
Find instant savings
Lowest price near you
$12.4
Find instant savings
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Reviews
31 
74%
think this treatment is worth it
68%
think this treatment works well
19%
think this treatment is a hassle

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Side effects
6possible side effects
  • Pain and other pressure sensations
    6%
  • Atypical sensations
    5%
  • Paresthesia (all types)
    3%
  • Sensation warm/cold
    3%
  • Pain - location specified
    2%
  • Malaise/fatigue
    2%
See more detailed side effects
4possible side effects
  • Changes in taste
    20%
  • Discomfort in the nose
    11%
  • Runny nose
    5%
  • Stuffy nose
    2%
See more detailed side effects
Risks and warnings
  • Tightening of blood vessels (myocardial angina, ischemia, or infarction)

    History of heart problems

    ...and 5 more risk factors

  • Stroke

    History of heart problems

    ...and 5 more risk factors

  • Serotonin syndrome

    Patients taking SSRIs and SNRIs

  • High blood pressure

    History of high blood pressure

  • Seizures

    History of seizures

See more detailed risks and warnings
  • Heart attack

    Heart disease

    ...and 2 more risk factors

  • Stroke

    History of a stroke

  • Medication overuse headache

    Using Onzetra (sumatriptan) for more than 10 days a month

  • Serotonin syndrome

    Tricyclic antidepressants

    ...and 5 more risk factors

  • Higher blood pressure

    Uncontrolled high blood pressure

  • Suicidal behavior

    Taking medicines for seizures

  • Blood vessel issues

    High blood pressure

    ...and 1 more risk factors

See more detailed risks and warnings