Compare Imitrex vs. Topamax

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Imitrex
(sumatriptan)

Qudexy Xr
(topiramate)

Treats migraine headaches. Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.
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Coupons for Imitrex
Best available price for 9 (9 tablets of 100mg) dose packs of sumatriptan
Coupons for Topamax
Best available price for 60 (25mg) tablets of topamax
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.29Imitrex
Reviews for Imitrex
74%
of people (All ages) say Imitrex is worth it
68%
say it works well
19%
say it's a big hassle
Have you used Imitrex (sumatriptan)?
Worth itNot sureNot worth it
Reviews for Topamax
52%
+22% better vs. Imitrex
50%
+18% better vs. Imitrex
36%
+17% better vs. Imitrex
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
Side effects
ImitrexTopamax
  • Pain and other pressure sensations 2%
  • Atypical sensations 1%
  • Paresthesia (all types) 1%
  • Sensation warm/cold 1%
  • Pain - location specified 1%
  • Malaise/fatigue 2%
  • Chest - pain/tightness/pressure and/or heaviness 1%
  • Neck/throat/jaw - pain/ tightness/pressure 2%
  • Other - pressure/tightness/ heaviness 1%
  • Vertigo 2%
More Imitrex side effects »
  • Ear, nose, or throat infection 16%
  • Diarrhea 8%
  • Weight decrease 7%
  • Difficulty with concentration/attention 7%
  • Inflammation inside the nose 5%
  • Tingling sensation 3%
  • Infection 3%
  • Infection viral 3%
  • Rash 3%
  • Fatigue 17%
More Topamax side effects »
How it works
ImitrexTopamax
Imitrex (Sumatriptan) is a triptan medication that treats migraine headaches. It releases serotonin, which lowers the inflammation that causes headaches.Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.
Type of medication
ImitrexTopamax
Prescription onlyPrescription only
Available as
ImitrexTopamax
  • Pill
  • Injection
  • Nasal spray
  • Pill
  • Extended release capsule
Used for
ImitrexTopamax
Risk factors for serious side effects
ImitrexTopamax
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
Detailed Imitrex (sumatriptan) risks & warnings »
  • History of depression
  • Children
  • History of metabolic disorders
  • People also taking Depakote
  • Low-carb diet
Detailed Qudexy Xr (topiramate) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
ImitrexTopamax
No kidneys and liver related info.
  • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
  • A few people will get kidney stones.
Sleep
ImitrexTopamax
  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
No sleep related info.
Weight
ImitrexTopamax
No weight related info.
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
Upsides and benefits
ImitrexTopamax
  • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
  • A combination of forms can be used if symptoms do not improve.
  • The nasal spray and injectable forms work very quickly.
  • It's generally safe to use if you are pregnant.
  • Comes in a generic form, so it can be pretty cheap.
  • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
  • Helpful in preventing frequent migraine headaches.
  • Doesn't need routine blood tests.
Downsides and risks
ImitrexTopamax
  • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
  • Does not prevent migraine headaches; it only treats them once they start.
  • Must wait 1 hour before using second injection.
  • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
  • Need to have your blood pressure checked often, especially if you're pregnant.
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • A few people will get kidney stones.
  • Not safe to use if you're pregnant.
Tips from our pharmacists for people taking the medication
ImitrexTopamax
  • Take it as soon as your headache starts.
  • If you use the nasal spray, be sure to blow your nose before using it.
  • If you use the patch, put it on a dry area free of scars, tattoos, or other cuts and scrapes. Be sure to press the button to activate it.
  • If you use the injection, you can use a second injection if you still have a headache after an hour. If you have symptoms 2 hours after the injection, switch to the pill version.
  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
  • Lie down in a dark room after taking Imitrex (Sumatriptan) to help ease the pain.
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Can cause tingling skin sensations and reduced appetite.
  • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
  • Takes 3 to 4 weeks to feel full effects on mood.
Learn more
More about ImitrexSide effectsReviews & ratingsFDA package insert
Have you used Imitrex (sumatriptan)?
Worth itNot sureNot worth it
More about TopamaxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it