Compare Imitrex vs. Topamax

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Imitrex (Sumatriptan)

Prescription only

Qudexy Xr (Topiramate)

Prescription only
Treats migraine headaches.

Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.

5.3/ 7 average rating with 31 reviewsforImitrex
Prevents seizures and migraine headaches.

Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.

4.4/ 7 average rating with 56 reviewsforTopamax
Upsides
  • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
  • A combination of forms can be used if symptoms do not improve.
  • The nasal spray and injectable forms work very quickly.
  • It's generally safe to use if you are pregnant.
  • Comes in a generic form, so it can be pretty cheap.
  • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
  • Helpful in preventing frequent migraine headaches.
  • Doesn't need routine blood tests.
Downsides
  • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
  • Does not prevent migraine headaches; it only treats them once they start.
  • Must wait 1 hour before using second injection.
  • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
  • Need to have your blood pressure checked often, especially if you're pregnant.
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • A few people will get kidney stones.
  • Not safe to use if you're pregnant.
Used for
Dosage forms
  • Pill
  • Injection
  • Nasal spray
  • Pill
  • Extended release capsule
Price
Lowest price near you
$12.4
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Lowest price near you
$10.2
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Reviews
31 
74%
think this treatment is worth it
68%
think this treatment works well
19%
think this treatment is a hassle

Have you used Imitrex (Sumatriptan)?

Leave a review
56 
52%
think this treatment is worth it
50%
think this treatment works well
36%
think this treatment is a hassle

Have you used Qudexy Xr (Topiramate)?

Leave a review
Side effects
6possible side effects
  • Pain and other pressure sensations
    6%
  • Atypical sensations
    5%
  • Paresthesia (all types)
    3%
  • Sensation warm/cold
    3%
  • Pain - location specified
    2%
  • Malaise/fatigue
    2%
See more detailed side effects
10possible side effects
  • Somnolence
    28%
  • Dizziness
    25%
  • Ataxia
    16%
  • Nervousness
    16%
  • Fatigue
    15%
  • Speech disorders/Related speech problems
    13%
  • Psychomotor slowing
    13%
  • Vision abnormal
    13%
  • Difficulty with memory
    12%
  • Paresthesia
    11%
See more detailed side effects
Risks and warnings
  • Tightening of blood vessels (myocardial angina, ischemia, or infarction)

    History of heart problems

    ...and 5 more risk factors

  • Stroke

    History of heart problems

    ...and 5 more risk factors

  • Serotonin syndrome

    Patients taking SSRIs and SNRIs

  • High blood pressure

    History of high blood pressure

  • Seizures

    History of seizures

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    History of depression

  • Uncontrolled body temperature

    Children

  • Mental changes due to high ammonia

    History of metabolic disorders

    ...and 1 more risk factors

  • Kidney stones

    Low-carb diet

    ...and 2 more risk factors

  • Withdrawal seizures

    Stopping Qudexy Xr (Topiramate) suddenly

See more detailed risks and warnings