Compare Imitrex vs. Topamax

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Imitrex
(Sumatriptan)

Qudexy Xr
(Topiramate)

Treats migraine headaches. Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.538461538461538Imitrex
Reviews for Imitrex (Sumatriptan)
77%
of people say Imitrex (Sumatriptan) is worth it
73%
say it works well
15%
say it's a big hassle
Reviews for Qudexy Xr (Topiramate)
54%
23% vs. Imitrex (Sumatriptan)
52%
21% vs. Imitrex (Sumatriptan)
33%
18% vs. Imitrex (Sumatriptan)
Side effects
ImitrexTopamax
  • Pain and other pressure sensations 4%
  • Paresthesia (all types) 3%
  • Atypical sensations 2%
  • Chest - pain/tightness/pressure and/or heaviness 1%
  • Pain - location specified 1%
  • Sensation warm/cold 1%
  • Other - pressure/tightness/ heaviness 1%
More Imitrex side effects »
  • Tingling sensation 45%
  • Slowed-down thinking and movements 19%
  • Dizziness 17%
  • Drowsiness 17%
  • Fatigue 17%
  • Change in taste 14%
  • Difficulty with concentration/attention 13%
  • Nervousness 12%
  • Difficulty with memory 11%
  • Vision abnormal 11%
More Topamax side effects »
How it works
ImitrexTopamax
Imitrex (Sumatriptan) is a triptan medication that treats migraine headaches. It releases serotonin, which lowers the inflammation that causes headaches.Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.
Type of medication
ImitrexTopamax
Antimigraine
Triptan
Prescription only
AnticonvulsantPrescription only
Available as
ImitrexTopamax
  • Pill
  • Injection
  • Nasal spray
  • Pill
  • Extended release capsule
Used for (click to learn more)
ImitrexTopamax
Risk factors for serious side effects
ImitrexTopamax
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
  • Smoking
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
  • Smoking
    • Patients taking SSRIs and SNRIs
    • History of high blood pressure
    • History of seizures
    Detailed Imitrex (Sumatriptan) risks & warnings »
    • History of depression
      • Children
      • History of metabolic disorders
      • People also taking Depakote
      • Low-carb diet
      • Dehydration
      • Drug interactions
        • Stopping Qudexy Xr (Topiramate) suddenly
        Detailed Qudexy Xr (Topiramate) risks & warnings »
        Pregnancy category
        ImitrexTopamax
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        DFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.
        • A few people will get kidney stones.
        • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
        No specific sleep-related info.
        Weight
        No specific weight-related info.
        • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
        Upsides and benefits
        ImitrexTopamax
        • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
        • A combination of forms can be used if symptoms do not improve.
        • The nasal spray and injectable forms work very quickly.
        • It's generally safe to use if you are pregnant.
        • Comes in a generic form, so it can be pretty cheap.
        • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
        • Helpful in preventing frequent migraine headaches.
        • Doesn't need routine blood tests.
        Downsides and risks
        ImitrexTopamax
        • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
        • Does not prevent migraine headaches; it only treats them once they start.
        • Must wait 1 hour before using second injection.
        • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
        • Need to have your blood pressure checked often, especially if you're pregnant.
        • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
        • A few people will get kidney stones.
        • Not safe to use if you're pregnant.
        Tips from our pharmacists for people taking the medication
        ImitrexTopamax
        • Take it as soon as your headache starts.
        • If you use the nasal spray, be sure to blow your nose before using it.
        • If you use the patch, put it on a dry area free of scars, tattoos, or other cuts and scrapes. Be sure to press the button to activate it.
        • If you use the injection, you can use a second injection if you still have a headache after an hour. If you have symptoms 2 hours after the injection, switch to the pill version.
        • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
        • Lie down in a dark room after taking Imitrex (Sumatriptan) to help ease the pain.
        • For the first week, avoid activities that require you to be alert.
        • Don't use if pregnant.
        • Can cause tingling skin sensations and reduced appetite.
        • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
        • Takes 3 to 4 weeks to feel full effects on mood.
        Learn more
        More about ImitrexSide effectsReviews & ratingsAlternativesFDA package insert
        More about TopamaxSide effectsReviews & ratingsAlternativesFDA package insert