Compare Imitrex vs. Zomig

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Imitrex (Sumatriptan)

Prescription only

Zomig (zolmitriptan)

Prescription only
Treats migraine headaches.

Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.

3.9/ 5 average rating with 31 reviewsforImitrex
Treats migraines.

Triptans are the first-choice to treat migraines. Zomig (zolmitriptan) works just as well as other triptans for migraines.

Upsides
  • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
  • A combination of forms can be used if symptoms do not improve.
  • The nasal spray and injectable forms work very quickly.
  • It's generally safe to use if you are pregnant.
  • Comes in a generic form, so it can be pretty cheap.
  • Zomig (zolmitriptan) is is a first choice treatment to treat severe migraines.
  • There are different forms of Zomig (zolmitriptan) available, including a dissolving pill and a nasal spray if you have trouble swallowing during a migraine attack.
  • The regular and dissolving pill forms of Zomig (zolmitriptan) are available as generics.
Downsides
  • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
  • Does not prevent migraine headaches; it only treats them once they start.
  • Must wait 1 hour before using second injection.
  • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
  • Need to have your blood pressure checked often, especially if you're pregnant.
  • If you're taking the nasal spray form of Zomig (zolmitriptan), you have to follow the instructions exactly or you won't get the full dose of medicine.
  • The nasal spray form of Zomig (zolmitriptan) is only available as brand name, so it can be expensive.
  • If you have heart disease or history of stroke, Zomig (zolmitriptan) may not be the best choice for you. Talk to your doctor about your medical history.
Used for
Dosage forms
  • Pill
  • Injection
  • Nasal spray
  • Pill
  • Dissolving tablet
  • Nasal spray
Price
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Reviews
31 reviews so far
74%
saidit'sworth it
68%
saiditworked well
19%
saidit'sa big hassle

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Side effects
6possible side effects
  • Pain and other pressure sensations
    6%
  • Atypical sensations
    5%
  • Paresthesia (all types)
    3%
  • Sensation warm/cold
    3%
  • Pain - location specified
    2%
  • Malaise/fatigue
    2%
See more detailed side effects
12possible side effects
  • Changes in taste
    21%
  • Tingling or prickling sensation
    10%
  • Oversensitivity of the skin
    5%
  • Pain
    4%
  • Pain in the throat
    4%
  • Nausea
    4%
  • Sleepiness
    4%
  • Discomfort in the nose
    3%
  • Dizziness
    3%
  • Weakness
    3%
  • Tightness in the throat
    2%
  • Dry mouth
    2%
See more detailed side effects
Risks and risk factors
  • Tightening of blood vessels (myocardial angina, ischemia, or infarction)
    • History of heart problems
    • High blood pressure
    • High cholesterol
    • Diabetes
    • Being overweight or obese
    • Smoking
  • Stroke
    • History of heart problems
    • High blood pressure
    • High cholesterol
    • Diabetes
    • Being overweight or obese
    • Smoking
  • Stomach bleeding
  • Serotonin syndrome
    • Patients taking SSRIs and SNRIs
  • High blood pressure
    • History of high blood pressure
  • Seizures
    • History of seizures
See more detailed risks and warnings
  • Heart attack
    • Heart disease
    • history of chest pain/angina
    • uncontrolled high blood pressure
  • Stroke
    • History of a stroke
  • Medication overuse headache
    • Using Zomig (zolmitriptan) or other migraine treatment medications for 10 or more days a month
  • Changes in heartbeat
    • History of arrhythmia
  • Serotonin syndrome
    • Taking tricyclic antidepressants, fentanyl, tramadol, buspirone, or ADHD medicines
  • Blood vessel issues
    • High blood pressure
    • history of stroke
See more detailed risks and warnings