Compare Imitrex vs. Zomig

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Imitrex
(sumatriptan)

Zomig
(zolmitriptan)

Treats migraine headaches. Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.Treats migraines. Triptans are the first-choice to treat migraines. Zomig (zolmitriptan) works just as well as other triptans for migraines.
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Coupons for Imitrex
Best available price for 1 (9 tablets of 100mg) dose pack of sumatriptan
Coupons for Zomig
Best available price for 1 (3 tablets of 5mg) dose pack of zolmitriptan
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.29Imitrex
Reviews for Imitrex (sumatriptan)
74%
of people (All ages) say Imitrex (sumatriptan) is worth it
68%
say it works well
19%
say it's a big hassle
Have you used Imitrex (sumatriptan)?
Worth itNot sureNot worth it
Reviews for Zomig (zolmitriptan)
Not enough review data. Review it!
+26% better vs. Imitrex (sumatriptan)
Not enough review data. Review it!
+32% better vs. Imitrex (sumatriptan)
Not enough review data. Review it!
+19% better vs. Imitrex (sumatriptan)
Have you used Zomig (zolmitriptan)?
Worth itNot sureNot worth it
Side effects
ImitrexZomig
  • Pain and other pressure sensations 2%
  • Atypical sensations 1%
  • Paresthesia (all types) 1%
  • Sensation warm/cold 1%
  • Pain - location specified 1%
  • Malaise/fatigue 2%
  • Chest - pain/tightness/pressure and/or heaviness 1%
  • Neck/throat/jaw - pain/ tightness/pressure 2%
  • Other - pressure/tightness/ heaviness 1%
  • Vertigo 2%
More Imitrex side effects »
  • Nervous system problems 7%
  • Stomach problems 8%
  • Pain and pressure sensation 7%
  • Unusual sensations 6%
  • Nausea 5%
  • Dizziness 4%
  • Tingling or prickling sensation 5%
  • Neck, throat or jaw pain/pressure 4%
  • Sleepiness 3%
  • Warm or cold sensation 1%
More Zomig side effects »
How it works
ImitrexZomig
Imitrex (Sumatriptan) is a triptan medication that treats migraine headaches. It releases serotonin, which lowers the inflammation that causes headaches.Zomig (zolmitriptan) is a triptan. It prevents the enlargement of blood vessels in your brain, which causes migraines.
Type of medication
ImitrexZomig
Prescription only
Prescription only
Available as
ImitrexZomig
  • Pill
  • Injection
  • Nasal spray
  • Pill
  • Dissolving tablet
  • Nasal spray
Used for
ImitrexZomig
Risk factors for serious side effects
ImitrexZomig
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
Detailed Imitrex (sumatriptan) risks & warnings »
  • Heart disease
  • history of chest pain/angina
  • uncontrolled high blood pressure
  • History of a stroke
  • Using Zomig (zolmitriptan) or other migraine treatment medications for 10 or more days a month
Detailed Zomig (zolmitriptan) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Sleep
ImitrexZomig
  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
No sleep related info.
Upsides and benefits
ImitrexZomig
  • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
  • A combination of forms can be used if symptoms do not improve.
  • The nasal spray and injectable forms work very quickly.
  • It's generally safe to use if you are pregnant.
  • Comes in a generic form, so it can be pretty cheap.
  • Zomig (zolmitriptan) is is a first choice treatment to treat severe migraines.
  • There are different forms of Zomig (zolmitriptan) available, including a dissolving pill and a nasal spray if you have trouble swallowing during a migraine attack.
  • The regular and dissolving pill forms of Zomig (zolmitriptan) are available as generics.
Downsides and risks
ImitrexZomig
  • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
  • Does not prevent migraine headaches; it only treats them once they start.
  • Must wait 1 hour before using second injection.
  • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
  • Need to have your blood pressure checked often, especially if you're pregnant.
  • If you're taking the nasal spray form of Zomig (zolmitriptan), you have to follow the instructions exactly or you won't get the full dose of medicine.
  • The nasal spray form of Zomig (zolmitriptan) is only available as brand name, so it can be expensive.
  • If you have heart disease or history of stroke, Zomig (zolmitriptan) may not be the best choice for you. Talk to your doctor about your medical history.
Tips from our pharmacists for people taking the medication
ImitrexZomig
  • Take it as soon as your headache starts.
  • If you use the nasal spray, be sure to blow your nose before using it.
  • If you use the patch, put it on a dry area free of scars, tattoos, or other cuts and scrapes. Be sure to press the button to activate it.
  • If you use the injection, you can use a second injection if you still have a headache after an hour. If you have symptoms 2 hours after the injection, switch to the pill version.
  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
  • Lie down in a dark room after taking Imitrex (Sumatriptan) to help ease the pain.
  • Doesn't prevent migraines.
  • Use as soon as you feel a migraine starting. You can take another dose 2 hours later, but don't take more than 10 mg total in 24 hours.
  • Don't use it excessively since it can cause you to have more headaches. Talk to your doctor if you are having more than 4 migraines in a month.
Learn more
More about ImitrexSide effectsReviews & ratingsFDA package insert
Have you used Imitrex (sumatriptan)?
Worth itNot sureNot worth it
More about ZomigSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zomig (zolmitriptan)?
Worth itNot sureNot worth it