Compare Imodium vs. Pepcid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Imodium (Loperamide)

Over-the-counter

Pepcid (Famotidine)

Prescription or OTC
Treats diarrhea.

One day is too many days to have diarrhea. Having Imodium (Loperamide) on hand to relieve your symptoms can be a life-saver.

5.8/ 7 average rating with 285 reviewsforImodium
Relieves heartburn.

Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.

5.1/ 7 average rating with 853 reviewsforPepcid
Upsides
  • Most people who take Imodium feel there's no hassle and it's definitely worth it!
  • Non-habit forming and available over-the-counter.
  • It comes in caplets, liquid, and chewable tablets so you can use it anywhere you need it.
  • Imodium is used for short-term, chronic and traveler's diarrhea. It's also used for people who have diarrhea caused by cancer or certain medicines that treat cancer.
  • Most people can take Famotidine without any noticeable day-to-day side effects.
  • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
Downsides
  • Imodium only treats your diarrhea symptoms. Diarrhea may be caused by a number of conditions and will need specific treatment that deals with the underlying issue.
  • Studies in people taking Imodium for chronic diarrhea showed if the maximum number of doses didn't relieve symptoms in 10 days, then it probably won't work for that condition. You can talk to your doctor about other treatment options.
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
Used for
Dosage forms
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
  • Chewable tablet
  • Liquid
Price
Lowest price near you
$54.86
Find instant savings
Lowest price near you
$4
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
285 
89%
think this treatment is worth it
65%
think this treatment works well
6%
think this treatment is a hassle

Have you used Imodium (Loperamide)?

Leave a review
853 
75%
think this treatment is worth it
41%
think this treatment works well
8%
think this treatment is a hassle

Have you used Pepcid (Famotidine)?

Leave a review
Side effects
1possible side effects
  • Constipation
    3%
See more detailed side effects
2possible side effects
  • Headache
    5%
  • Diarrhea
    2%
See more detailed side effects
Risks and warnings
  • Allergic reactions

    Allergy to loperamide

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Liver problems

    Current liver problems

  • Serious intestinal problems

    Taking HIV medicines

    ...and 1 more risk factors

  • Risk to fetus

    Women of childbearing age

See more detailed risks and warnings
  • Increased side effects

    Current kidney disease

See more detailed risks and warnings