Compare Imodium vs. Zantac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Imodium (Loperamide)

Over-the-counter

Zantac 75 (ranitidine)

Prescription or OTC
Treats diarrhea.

One day is too many days to have diarrhea. Having Imodium (Loperamide) on hand to relieve your symptoms can be a life-saver.

4.2/ 5 average rating with 285 reviewsforImodium
Relieves heartburn and stomach ulcers.

Zantac 75 (ranitidine) is an effective and inexpensive medicine for hearburn with few side effects, but may interfere with other drugs.

3.7/ 5 average rating with 1062 reviewsforZantac
Upsides
  • Most people who take Imodium feel there's no hassle and it's definitely worth it!
  • Non-habit forming and available over-the-counter.
  • It comes in caplets, liquid, and chewable tablets so you can use it anywhere you need it.
  • Imodium is used for short-term, chronic and traveler's diarrhea. It's also used for people who have diarrhea caused by cancer or certain medicines that treat cancer.
  • Zantac 75 (ranitidine) works well to relieve heartburn symtoms and is quite tolerable.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • If you have trouble swallowing pills you may find the liquid product a good option.
  • Inexpensive with over-the-counter and generic options.
  • Coupons are available for the brand product - speak to your doctor or pharmacist.
Downsides
  • Imodium only treats your diarrhea symptoms. Diarrhea may be caused by a number of conditions and will need specific treatment that deals with the underlying issue.
  • Studies in people taking Imodium for chronic diarrhea showed if the maximum number of doses didn't relieve symptoms in 10 days, then it probably won't work for that condition. You can talk to your doctor about other treatment options.
  • Zantac 75 (ranitidine) doesn't work as quickly as some other acid reducers. Speak to your doctor or pharmacist if you need quicker relief.
  • Zantac 75 (ranitidine) does not last as long as some other acid reducers. Speak to your doctor or pharmacist if you need longer relief.
  • May not be as effective in healing the esophagus when it is inflammed or torn, known as erosive esophagitis. Your doctor will assess which medication is best for you.
  • Can lower your vitamin B12 levels if you use Zantac 75 (ranitidine) for a long time. Your doctor can order lab tests to monitor your vitamin B12 levels.
Used for
Dosage forms
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
  • Oral solution
  • Oral syrup
  • Injection
Price
No pricing information available
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Reviews
285 reviews so far
89%
saidit'sworth it
65%
saiditworked well
6%
saidit'sa big hassle

Have you used Imodium (Loperamide)?

Leave a review
1062 reviews so far
72%
saidit'sworth it
44%
saiditworked well
7%
saidit'sa big hassle

Have you used Zantac 75 (ranitidine)?

Leave a review
Side effects
1possible side effects
  • Constipation
    3%
See more detailed side effects
The Zantac 75 (ranitidine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Allergic reactions
    • Allergy to loperamide
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Liver problems
    • Current liver problems
  • Serious intestinal problems
    • Taking HIV medicines
    • Active infectious colitis
  • Risk to fetus
    • Women of childbearing age
See more detailed risks and warnings
  • Confusion
    • Aged 60 years or older
    • Kidney conditions
    • Liver conditions
  • Drug interactions
  • Acute porphyria
    • Acute Porphyria
  • Chronic lung problems
    • Asthma
    • COPD
    • Lung problems
See more detailed risks and warnings