Compare Imuran vs. Humira

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Imuran
(azathioprine)

Humira
(adalimumab)

Prevents organ rejection and relieves joint pain and inflammation. Imuran (Azathioprine) is an effective medication for the treatment of rheumatoid arthritis and transplant rejection, but comes with a heavy list of side effects.Calms down the immune system. Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.
Reviews & ratings
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Have you used Imuran (azathioprine)?
Worth itNot sureNot worth it
Reviews for Humira
60%
-35% worse vs. Imuran
51%
-26% worse vs. Imuran
26%
-24% worse vs. Imuran
182 reviews
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it
Side effects
ImuranHumira
  • Infections 20%
  • Leukopenia <2500 cells/mm3 16%
  • Leukopenia (any degree) 28%
  • Nausea and vomiting 12%
More Imuran side effects »
  • Upper airway infection 4%
  • Rash 6%
  • Headache 4%
  • Sinus infection 2%
  • Nausea 1%
  • Injection site reactions 7%
  • Urinary tract infection 3%
  • Flu syndrome 1%
  • Stomach pain 3%
  • High cholesterol 2%
More Humira side effects »
How it works
ImuranHumira
Imuran (Azathioprine) is an immunosuppressant medication. It blocks the production of the white blood cells that kill unfamiliar cells.Humira (adalimumab) is a TNF blocker which stops inflammation.
Type of medication
ImuranHumira
Prescription onlyPrescription only
Available as
ImuranHumira
  • Pill
  • Injection
Used for
ImuranHumira
Risk factors for serious side effects
ImuranHumira
  • Sexually active men and women
  • Pregnant women
  • Child-bearing women
Detailed Imuran (azathioprine) risks & warnings »
  • Taking other immunosuppressant medications such as Kineret or Orencia
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • Comorbidities
  • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
Detailed Humira (adalimumab) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
ImuranHumira
  • Drinking alcohol is okay while taking Imuran (Azathioprine).
No alcohol related info.
Upsides and benefits
ImuranHumira
  • Imuran (Azathioprine) has proven to be effective in the treatment of rheumatoid arthritis.
  • Imuran (Azathioprine) decreases the pain, stiffness, and swelling that most people have with rheumatoid arthritis.
  • You can still get vaccinated for the flu while taking Imuran (Azathioprine).
  • Drinking alcohol is okay while taking Imuran (Azathioprine).
  • Most side effects are temporary.
  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
Downsides and risks
ImuranHumira
  • If you take Imuran (Azathioprine) for rheumatoid arthritis, you'll likely need to take additional medications to control your symptoms.
  • While taking Imuran (Azathioprine), you will have to get your blood tested once a week for the first month, every other week for the second and third month, and once every month after that.
  • Along with other side effects, your hair may begin to change color or fall out when you first start taking Imuran (Azathioprine), but this is usually temporary.
  • You'll likely have to take additional medications, like methotrexate to keep your rheumatoid arthritis in remission.
  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
Tips from our pharmacists for people taking the medication
ImuranHumira
  • If you're sexually active, you and your partner should use birth control, since Imuran (Azathioprine) can cause birth defects.
  • If you take Imuran (Azathioprine) for rheumatoid arthritis, your joint damage can’t be reversed, so keep up with your physical therapy and get plenty of rest.
  • While taking Imuran (Azathioprine), your body is susceptible to infection; so be sure to wash your hands often and keep distance from with people who are sick.
  • It is typical to have some nausea when you first start taking Imuran (Azathioprine); if it's unbearable, let your doctor know.
  • Don't sun tan while taking this medication. Always use sunscreen and wear a long-sleeved shirt, pants, hat, and sunglasses.
  • Humira (adalimumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so on your own.
  • Humira (adalimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
  • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
  • Each time you use Humira (adalimumab), it's important to rotate the sites you chose to inject it in. Don't inject Humira (adalimumab) into skin that's red, bruised, or irritated.
  • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container, and not in the trash.
Learn more
More about ImuranSide effectsReviews & ratingsFDA package insert
Have you used Imuran (azathioprine)?
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More about HumiraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Humira (adalimumab)?
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