Compare Imuran vs. Sulfasalazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Imuran
(azathioprine)

Azulfidine
(sulfasalazine)

Prevents organ rejection and relieves joint pain and inflammation. Imuran (Azathioprine) is an effective medication for the treatment of rheumatoid arthritis and transplant rejection, but comes with a heavy list of side effects.Reduces inflammation. Azulfidine (Sulfasalazine) is used for moderate to severe inflammatory bowel conditions, and with other meds for treating rheumatoid arthritis.
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Coupons for Imuran
Best available price for 60 (50mg) tablets of azathioprine
Coupons for Sulfasalazine
Best available price for 120 (500mg) tablets of sulfasalazine
Reviews & ratings
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Reviews for Imuran (azathioprine)
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of people (All ages) say Imuran (azathioprine) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Imuran (azathioprine)?
Worth itNot sureNot worth it
Reviews for Azulfidine (sulfasalazine)
Not enough review data. Review it!
-25% worse vs. Imuran (azathioprine)
Not enough review data. Review it!
-25% worse vs. Imuran (azathioprine)
Not enough review data. Review it!
+50% better vs. Imuran (azathioprine)
Have you used Azulfidine (sulfasalazine)?
Worth itNot sureNot worth it
Side effects
ImuranSulfasalazine
  • Infections 20%
  • Leukopenia <2500 cells/mm3 16%
  • Leukopenia (any degree) 28%
  • Nausea and vomiting 12%
More Imuran side effects »

We haven’t found good data for Sulfasalazine side effects.

FDA side effect reports for Sulfasalazine »
How it works
ImuranSulfasalazine
Imuran (Azathioprine) is an immunosuppressant medication. It blocks the production of the white blood cells that kill unfamiliar cells.Azulfidine (Sulfasalazine) is an anti-inflammatory drug that reduces inflammation and pain. It treats inflammatory bowel diseases and rheumatoid arthritis.
Type of medication
ImuranSulfasalazine
Prescription only
Prescription only
Available as
ImuranSulfasalazine
  • Pill
  • Pill
  • Extended release
Used for
ImuranSulfasalazine
Risk factors for serious side effects
ImuranSulfasalazine
  • Sexually active men and women
  • Pregnant women
  • Child-bearing women
Detailed Imuran (azathioprine) risks & warnings »
    Detailed Azulfidine (sulfasalazine) risks & warnings »
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Alcohol
    ImuranSulfasalazine
    • Drinking alcohol is okay while taking Imuran (Azathioprine).
    No alcohol related info.
    Food
    ImuranSulfasalazine
    No food related info.
    • Swallow tablets whole, and take after a meal with a full glass of water.
    Kidneys and liver
    ImuranSulfasalazine
    No kidneys and liver related info.
    • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
    • Severe hypersensitivity reactions can include internal organ involvement, such as hepatitis (liver), nephritis (kidney), myocarditis (heart), blood abnormalities, or pneumonitis (lungs).
    Upsides and benefits
    ImuranSulfasalazine
    • Imuran (Azathioprine) has proven to be effective in the treatment of rheumatoid arthritis.
    • Imuran (Azathioprine) decreases the pain, stiffness, and swelling that most people have with rheumatoid arthritis.
    • You can still get vaccinated for the flu while taking Imuran (Azathioprine).
    • Drinking alcohol is okay while taking Imuran (Azathioprine).
    • Most side effects are temporary.
    • When taken consistently, Azulfidine (Sulfasalazine) can control your symptoms of ulcerative colitis and other bowel diseases.
    • Azulfidine (Sulfasalazine) is usually used in combination with other medications to control rheumatoid arthritis.
    Downsides and risks
    ImuranSulfasalazine
    • If you take Imuran (Azathioprine) for rheumatoid arthritis, you'll likely need to take additional medications to control your symptoms.
    • While taking Imuran (Azathioprine), you will have to get your blood tested once a week for the first month, every other week for the second and third month, and once every month after that.
    • Along with other side effects, your hair may begin to change color or fall out when you first start taking Imuran (Azathioprine), but this is usually temporary.
    • You'll likely have to take additional medications, like methotrexate to keep your rheumatoid arthritis in remission.
    • You need to have blood tests every 3 months when taking Azulfidine (Sulfasalazine).
    • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
    • Can't take Azulfidine (Sulfasalazine) if you are allergic to aspirin or sulfa medications.
    • Azulfidine (Sulfasalazine) shouldn't be used if you are breastfeeding.
    Tips from our pharmacists for people taking the medication
    ImuranSulfasalazine
    • If you're sexually active, you and your partner should use birth control, since Imuran (Azathioprine) can cause birth defects.
    • If you take Imuran (Azathioprine) for rheumatoid arthritis, your joint damage can’t be reversed, so keep up with your physical therapy and get plenty of rest.
    • While taking Imuran (Azathioprine), your body is susceptible to infection; so be sure to wash your hands often and keep distance from with people who are sick.
    • It is typical to have some nausea when you first start taking Imuran (Azathioprine); if it's unbearable, let your doctor know.
    • Don't sun tan while taking this medication. Always use sunscreen and wear a long-sleeved shirt, pants, hat, and sunglasses.
    • Don't use if you are allergic to sulfa drugs or aspirin.
    • Swallow tablets whole, and take after a meal with a full glass of water.
    • Drink at least six glasses of water daily while on this.
    • Continue to take Azulfidine (Sulfasalazine) even once you feel better.
    • Read the information that come with your medication in the drugstore since there are many conditions you should be aware of before taking Azulfidine (Sulfasalazine).
    • Can cause an orange color in your urine or skin.
    Learn more
    More about ImuranSide effectsReviews & ratingsFDA package insert
    Have you used Imuran (azathioprine)?
    Worth itNot sureNot worth it
    More about SulfasalazineSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Azulfidine (sulfasalazine)?
    Worth itNot sureNot worth it