Compare Imuran vs. Sulfasalazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Imuran (Azathioprine)

Prescription only
Prevents organ rejection and relieves joint pain and inflammation.

Imuran (Azathioprine) is an effective medication for the treatment of rheumatoid arthritis and transplant rejection, but comes with a heavy list of side effects.

Reduces inflammation.

Azulfidine (Sulfasalazine) is used to treat moderate to severe inflammatory bowel conditions. It's also used with other medicines to treat rheumatoid arthritis.

Upsides
  • Imuran (Azathioprine) has proven to be effective in the treatment of rheumatoid arthritis.
  • Imuran (Azathioprine) decreases the pain, stiffness, and swelling that most people have with rheumatoid arthritis.
  • You can still get vaccinated for the flu while taking Imuran (Azathioprine).
  • Drinking alcohol is okay while taking Imuran (Azathioprine).
  • Most side effects are temporary.
  • Can slow down the progression of your rheumatoid arthritis.
  • Helps control your stomach problems if you're taking it for ulcerative colitis.
Downsides
  • If you take Imuran (Azathioprine) for rheumatoid arthritis, you'll likely need to take additional medications to control your symptoms.
  • While taking Imuran (Azathioprine), you will have to get your blood tested once a week for the first month, every other week for the second and third month, and once every month after that.
  • Along with other side effects, your hair may begin to change color or fall out when you first start taking Imuran (Azathioprine), but this is usually temporary.
  • You'll likely have to take additional medications, like methotrexate to keep your rheumatoid arthritis in remission.
  • Requires constant lab monitoring, at least every other week when you first start using it.
  • Not a good option if you have kidney or liver disease.
  • If you're allergic to sulfa drugs or aspirin, you can't take Azulfidine (Sulfasalazine).
  • Can interfere with lab test results, so let your doctor know if you're taking this drug.
  • Interacts with a lot of different drugs and can also cause many side effects.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
Price
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Reviews
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Side effects
2possible side effects
  • Infections
    20%
  • Leukopenia <2500 cells/mm3
    16%
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8possible side effects
  • Nausea
    19%
  • Stomach problems
    13%
  • Rash
    13%
  • Headache
    9%
  • Stomach pain
    8%
  • Vomiting
    8%
  • Fever
    5%
  • Dizziness
    4%
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Risks and risk factors
  • Cancer
  • Decreased blood cells
  • Increased risk for infection
  • Harm to fetus
    • Sexually active men and women
    • Pregnant women
    • Child-bearing women
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  • Kidney, liver, or blood problems
  • Serious skin reactions
  • Serious allergic reactions
  • Serious infections
  • Drug interactions
See more detailed risks and warnings