Compare Indocin vs. Allopurinol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Indocin (indomethacin)

Prescription only

Zyloprim (allopurinol)

Prescription only
Treats pain and swelling.

Indocin (indomethacin) works well for mild to moderate pain and swelling, but it shouldn't be used long-term since it has some serious side effects.

4.2/ 5 average rating with 26 reviewsforIndocin
Lowers uric acid levels in blood, and prevents gout flare-ups.

Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working.

3.7/ 5 average rating with 21 reviewsforAllopurinol
Upsides
  • Effective option to relieve mild to moderate pain and swelling.
  • Treats inflammation problems, such as rheumatoid arthritis, osteoarthritis, and acute gout attacks.
  • In studies, Indocin (indomethacin) was more effective than Tylenol for treating osteoarthritis pain.
  • It works as well as Celebrex for treating an acute gout attacks.
  • Available in capsules, long-acting capsules, suppositories, and as a suspension. All forms, except the suspension, are available as generic medications.
  • Zyloprim (allopurinol) works well to lower uric acid in the body.
  • It is available as a generic medication.
Downsides
  • Indocin (indomethacin) can cause serious heart and stomach problems. The risk goes up the longer you take it, but problems can happen at any time. Don't take Indocin (indomethacin) any longer than your doctor recommends.
  • Indocin (indomethacin) raises your risk of bleeding, especially when taken with other blood-thinning medicines.
  • There are similar medicines that you don't have to take as often and can work just as well.
  • Not a good choice if you have kidney, liver, or stomach problems.
  • Zyloprim (allopurinol) can raise the number of gout attacks in the first few weeks.
  • It can take 2 to 6 weeks to feel the full effects of Zyloprim (allopurinol).
  • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
Used for
Dosage forms
  • Pill
  • Extended release
  • Liquid
  • Suppository
  • Pill
  • Injection
Price
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Reviews
26 reviews so far
73%
saidit'sworth it
77%
saiditworked well
23%
saidit'sa big hassle

Have you used Indocin (indomethacin)?

Leave a review
21 reviews so far
71%
saidit'sworth it
52%
saiditworked well
5%
saidit'sa big hassle

Have you used Zyloprim (allopurinol)?

Leave a review
Side effects
15possible side effects
  • Nausea
    33%
  • Swelling after surgery
    22%
  • Headache
    14%
  • Dizziness
    14%
  • Bleeding after surgery
    11%
  • Vomiting
    10%
  • Constipation
    5%
  • Itchy skin
    3%
  • Diarrhea
    3%
  • Lightheadedness
    3%
  • Indigestion
    2%
  • Sleepiness
    2%
  • Excessive sweating
    2%
  • Lack of appetite
    2%
  • Fainting
    2%
See more detailed side effects
The Zyloprim (allopurinol) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Heart attack or stroke
    • History of heart disease
    • High blood pressure
    • Smoking
  • Stomach bleeding
    • History of stomach bleeding or ulcers
    • Age 65 or older
  • Harm to fetus (unborn baby)
    • Women of childbearing age
  • Serious allergic reactions
    • Asthma
    • Allergy to aspirin or other NSAIDs
  • Worsening kidney or liver function
    • Current kidney problems
    • Current liver problems
  • Bleeding or bruising
    • Blood-thinning medicines
    • Low blood platelet count
See more detailed risks and warnings
  • More gout attacks
  • Kidney stones
    • History of kidney stones
  • Skin rash
  • Liver disease
  • Sleepiness or dizziness
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
    • Elderly
See more detailed risks and warnings