Compare Indocin vs. Prednisone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Indocin
(indomethacin)

Deltasone
(prednisone)

Treats pain and swelling. Indocin (Indomethacin) works well for mild to moderate pain and swelling, but it shouldn't be used long-term since it has some serious side effects.Calms down your immune system. Deltasone (Prednisone) is a common oral corticosteroid that's great for controlling the unwanted symptoms from your immune responses and will make you feel better. There are lots of side effects but most of are tolerable or can be managed.
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Coupons for Indocin
Best available price for 30 (50mg) capsules of indomethacin
Coupons for Prednisone
Best available price for 10 (20mg) tablets of prednisone
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.85Indocin
Reviews for Indocin (indomethacin)
73%
of people (All ages) say Indocin (indomethacin) is worth it
77%
say it works well
23%
say it's a big hassle
Have you used Indocin (indomethacin)?
Worth itNot sureNot worth it
Reviews for Deltasone (prednisone)
59%
-14% worse vs. Indocin (indomethacin)
45%
-32% worse vs. Indocin (indomethacin)
20%
+3% better vs. Indocin (indomethacin)
540 reviews
Have you used Deltasone (prednisone)?
Worth itNot sureNot worth it
Side effects
IndocinPrednisone
  • Headache 5%
  • Post procedural hemorrhage 5%
  • Itching 3%
  • Diarrhea 1%
  • Rash 2%
More Indocin side effects »

The Prednisone FDA package insert doesn’t have numbers about how common side effects are.

More about Prednisone side effects »
How it works
IndocinPrednisone
Indocin (Indomethacin) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Deltasone (Prednisone) is a corticosteroid that's similar to what your body naturally makes. It reduces swelling and other immune responses that can cause you pain, discomfort, or harm.
Type of medication
IndocinPrednisone
Prescription only
Prescription only
Available as
IndocinPrednisone
  • Pill
  • Extended release
  • Liquid
  • Suppository
  • Pill
  • Extended release
  • Liquid
Used for
IndocinPrednisone
Risk factors for serious side effects
IndocinPrednisone
  • History of cardiovascular disease
  • High blood pressure
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 65 years or older
Detailed Indocin (indomethacin) risks & warnings »
  • Lowering dose or stopping too quickly especially after long-term treatment
  • Stress such as trauma, surgery or infection
  • Long-term treatment
  • Not vaccinated against viral diseases
  • Contact with people who have viral illness
Detailed Deltasone (prednisone) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Price
IndocinPrednisone
No price related info.
  • Short-term use in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
Food
IndocinPrednisone
  • Take with food or milk to help prevent upset stomach.
  • Take with food to decrease stomach upset.
Kidneys and liver
IndocinPrednisone
  • Not a good choice if you have kidney, liver, or stomach problems.
  • Indocin (Indomethacin) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need a different dose. (No dose adjustments are specified on the manufacturer's label.)
  • Adrenal suppression leading to adrenal crisis can occur if you lower your dose or stop taking Deltasone (Prednisone) too quickly. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your Deltasone (Prednisone) dose need to be done slowly over time. Talk to your doctor before you make any changes or stop the medication.
Pain
IndocinPrednisone
  • In studies, Indocin (Indomethacin) was more effective than Tylenol for treating osteoarthritis pain.
No pain related info.
Upsides and benefits
IndocinPrednisone
  • Effective option to relieve mild to moderate pain and swelling.
  • Treats inflammation problems, such as rheumatoid arthritis, osteoarthritis, and acute gout attacks.
  • In studies, Indocin (Indomethacin) was more effective than Tylenol for treating osteoarthritis pain.
  • It works as well as Celebrex for treating an acute gout attacks.
  • Available in capsules, long-acting capsules, suppositories, and as a suspension. All forms, except the suspension, are available as generic medications.
  • Steroid magic, can help you feel better, have more energy and get more appetite.
  • Useful for many conditions.
  • Short-term use in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
  • Long-term use in suppressing the immune system from causing your body harm, like many autoimmune related conditions.
Downsides and risks
IndocinPrednisone
  • Indocin (Indomethacin) can cause serious heart and stomach problems. The risk goes up the longer you take it, but problems can happen at any time. Don't take Indocin (Indomethacin) any longer than your doctor recommends.
  • Indocin (Indomethacin) raises your risk of bleeding, especially when taken with other blood-thinning medicines.
  • There are similar medicines that you don't have to take as often and can work just as well.
  • Not a good choice if you have kidney, liver, or stomach problems.
  • Lots of side effects, especially with long term use.
  • Short-term use can cause mood changes, trouble sleeping and increase in blood pressure, blood sugar, and possible water retention.
  • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
  • People with certain conditions will have to pay extra attention to their symptoms or may have to adjust the dose of other medicines when taking Prednisone.
  • When using corticosteroids for more than 1 week, you will need to work with a doctor to get off the medicine slowly.
  • Only available as an oral medicine so the rest of your body will be exposed to the medicine.
Tips from our pharmacists for people taking the medication
IndocinPrednisone
  • Takes about 30 minutes to start working and can last about 4 to 6 hours.
  • Can cause stomach ulcers or bleeding. Don't take it with other blood-thinning medicines without talking to your doctor first.
  • Can cause headaches. If the headaches continue even after you take a lower dose, talk to your doctor about stopping Indocin (Indomethacin).
  • The long-acting capsules must be swallowed whole. Don't crush them.
  • Take with food or milk to help prevent upset stomach.
  • The dose and duration on how long you need the medicine depends on your condition and response.
  • Take it exactly as your doctor prescribed.
  • Take with food to decrease stomach upset.
  • Can cause trouble sleeping. Take in the morning or 2-3 hours before bed if more than one dose is needed.
  • Can cause changes in mood, blood pressure, blood sugar, and water retention.
  • You should check your blood pressure and blood sugar when taking this medicine if you already have high blood pressure or diabetes.
  • A taper is is often needed to stop the medicine, especially if you've been on it for more than 1 week.
Learn more
More about IndocinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Indocin (indomethacin)?
Worth itNot sureNot worth it
More about PrednisoneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Deltasone (prednisone)?
Worth itNot sureNot worth it