Compare Indocin vs. prednisone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Indocin
(indomethacin)

prednisone

Treats pain and swelling. Indocin (indomethacin) works well for mild to moderate pain and swelling, but it shouldn't be used long-term since it has some serious side effects.Calms down your immune system. Deltasone (prednisone) is effective for controlling allergic reactions and conditions involving the immune system. It can quickly make you feel better, but Deltasone (prednisone) can cause serious complications and side effects if taken for a long time.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.85Indocin
Reviews for Indocin
73%
of people (All ages) say Indocin is worth it
77%
say it works well
23%
say it's a big hassle
Have you used Indocin (indomethacin)?
Worth itNot sureNot worth it
Reviews for prednisone
59%
+14% better vs. Indocin
45%
+32% better vs. Indocin
20%
-3% worse vs. Indocin
540 reviews
Have you used Deltasone (prednisone)?
Worth itNot sureNot worth it
Side effects
Indocinprednisone
  • Itchy skin 2%
  • Diarrhea 1%
  • Rash 2%
  • Upper stomach pain 1%
  • Sleepiness 1%
  • Indigestion 2%
More Indocin side effects »

The prednisone FDA package insert doesn’t have numbers about how common side effects are.

More about prednisone side effects »
How it works
Indocinprednisone
Indocin (indomethacin) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Deltasone (prednisone) is a corticosteroid similar to a hormone your body naturally makes in response to stress. It helps reduce swelling and blocks the actions of your immune system that normally would cause pain, discomfort, or harm.
Type of medication
Indocinprednisone
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
Indocinprednisone
  • Pill
  • Extended release
  • Liquid
  • Suppository
  • Pill
  • Delayed release pill
  • Liquid
Used for
Indocinprednisone
Risk factors for serious side effects
Indocinprednisone
  • History of heart disease
  • High blood pressure
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 65 or older
Detailed Indocin (indomethacin) risks & warnings »
  • Taking high doses of Deltasone (prednisone) for a long period of time
  • Young children
  • Stress such as trauma, injury, or infection
  • Taking other medicines that weaken the immune system
  • Taking Deltasone (prednisone) for a long time
Detailed Deltasone (prednisone) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
Indocinprednisone
  • Take with food or milk to help prevent upset stomach.
  • Take Deltasone (prednisone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
Kidneys and liver
Indocinprednisone
  • Indocin (indomethacin) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you might need a lower dose of Indocin (indomethacin), or your doctor might use a different medicine. Your doctor might have you do regular blood tests to make sure your kidneys and liver are healthy while you’re taking Indocin (indomethacin).
  • Not a good choice if you have kidney, liver, or stomach problems.
  • Deltasone (prednisone) can cause high blood pressure, unexplained weight gain, and other changes in the way your kidneys work. If you have a history of heart failure, high blood pressure, or kidney problems, talk to your doctor first before using this medicine.
Pain
Indocinprednisone
  • In studies, Indocin (indomethacin) was more effective than Tylenol for treating osteoarthritis pain.
No pain related info.
Upsides and benefits
Indocinprednisone
  • Effective option to relieve mild to moderate pain and swelling.
  • Treats inflammation problems, such as rheumatoid arthritis, osteoarthritis, and acute gout attacks.
  • In studies, Indocin (indomethacin) was more effective than Tylenol for treating osteoarthritis pain.
  • It works as well as Celebrex for treating an acute gout attacks.
  • Available in capsules, long-acting capsules, suppositories, and as a suspension. All forms, except the suspension, are available as generic medications.
  • Deltasone (prednisone) effectively treats a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Good long-term treatment option for autoimmune disorders.
  • Deltasone (prednisone) is available in a generic form.
Downsides and risks
Indocinprednisone
  • Indocin (indomethacin) can cause serious heart and stomach problems. The risk goes up the longer you take it, but problems can happen at any time. Don't take Indocin (indomethacin) any longer than your doctor recommends.
  • Indocin (indomethacin) raises your risk of bleeding, especially when taken with other blood-thinning medicines.
  • There are similar medicines that you don't have to take as often and can work just as well.
  • Not a good choice if you have kidney, liver, or stomach problems.
  • Deltasone (prednisone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Deltasone (prednisone) is used for more than 2 weeks, you will need to work with a doctor to taper off the medicine by gradually decreasing the dose.
  • Deltasone (prednisone) can harm an unborn baby, so it's not a good option for pregnant women.
Tips from our pharmacists for people taking the medication
Indocinprednisone
  • Takes about 30 minutes to start working.
  • Can cause stomach ulcers or bleeding. Don't take it with other blood-thinning medicines without talking to your doctor first.
  • Can cause headaches. If the headaches continue even after you take a lower dose, talk to your doctor about stopping Indocin (indomethacin).
  • The long-acting capsules must be swallowed whole. If you have trouble swallowing, there's a liquid available.
  • Take with food or milk to help prevent upset stomach.
  • Take Deltasone (prednisone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
  • Deltasone (prednisone) can increase your appetite, make your body retain more water, and cause changes to your mood.
  • Deltasone (prednisone) can increase your blood pressure and blood sugar at higher doses. If you have high blood pressure or diabetes, it is important that you check your blood pressure and blood sugar regularly while taking this medicine.
  • If you need to take Deltasone (prednisone) for longer than 2 weeks, you may need to gradually stop taking this medicine. Take it exactly as your doctor told you and do not stop suddenly.
  • Deltasone (prednisone) can increase your chances of getting an infection. Call your doctor right away if you have a fever, chills, flu-like symptoms, cough, pain with passing urine, or a wound that will not heal.
Learn more
More about IndocinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Indocin (indomethacin)?
Worth itNot sureNot worth it
More about prednisoneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Deltasone (prednisone)?
Worth itNot sureNot worth it