Compare Invega vs. Risperdal

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Invega
(paliperidone)

Risperdal
(risperidone)

Helps control your thoughts and mood. Invega (Paliperidone) is good for treating psychosis and improving mood. It's more likely to cause hormone problems than other antipsychotics.Helps control your thoughts and mood. Risperdal (Risperidone) is good for treating psychosis, mania, and irritability. Among newer antipsychotic medicines, more likely to cause side effects, especially weight gain and hormone problems.
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Coupons for Invega
Best available price for 30 (6mg) tablets of invega
Coupons for Risperdal
Best available price for 30 (1mg) tablets of risperdal
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.15Invega
Reviews for Invega
29%
of people (All ages) say Invega is worth it
32%
say it works well
35%
say it's a big hassle
Have you used Invega (paliperidone)?
Worth itNot sureNot worth it
Reviews for Risperdal
42%
-13% worse vs. Invega
47%
-15% worse vs. Invega
49%
+14% better vs. Invega
Have you used Risperdal (risperidone)?
Worth itNot sureNot worth it
Side effects
InvegaRisperdal
  • Abnormally fast heart beat 5%
  • Drowsiness 2%
  • Dizziness 1%
  • Abdominal pain upper 2%
  • Dry mouth 2%
  • Heart block 1%
  • Fatigue 1%
More Invega side effects »
  • Parkinsonism 16%
  • Relaxation or sleepiness 7%
  • Restlessness 6%
  • Tremor 3%
  • Dizziness 1%
  • Nausea 3%
  • Muscle twitching 4%
  • Diarrhea 1%
  • Excessive saliva 2%
  • Vision blurred 1%
More Risperdal side effects »
How it works
InvegaRisperdal
Invega (Paliperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affect your thoughts and mood.Risperdal (Risperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
InvegaRisperdal
Prescription onlyPrescription only
Available as
InvegaRisperdal
  • Extended release
  • Injection
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
Used for
InvegaRisperdal
Risk factors for serious side effects
InvegaRisperdal
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Invega (paliperidone) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Risperdal (risperidone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
InvegaRisperdal
  • Invega (Paliperidone) can increase your blood sugar and cholesterol. Invega (Paliperidone) is moderately likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Risperdal (Risperidone) can increase your blood sugar and cholesterol. Exercise and eat healthy food to lower your risk.
Sleep
InvegaRisperdal
  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
  • Can cause dizziness and drowsiness.
Weight
InvegaRisperdal
  • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Sometimes causes weight gain and low blood pressure.
  • Risperdal (Risperidone) can cause you to gain weight. Exercise and eat healthy food to lower your risk.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
Upsides and benefits
InvegaRisperdal
  • Effective at relieving psychotic symptoms and relapse rates for people with schizophrenia.
  • Also relieves psychotic symptoms and improves mood for people with schizoaffective disorder.
  • Works just as well as other antipsychotic medicines.
  • Less likely to cause heart or liver problems than some other antipsychotic medications.
  • Effective at relieving psychotic symptoms, manic episodes, irritability, and aggressive behavior.
  • Lowers relapse rates in people with schizophrenia and people with irritability associated with autism.
  • Antipsychotic medicines are all about equally effective.
  • Less likely to cause heart problems than some antipsychotics.
Downsides and risks
InvegaRisperdal
  • Invega (Paliperidone) has a high risk of causing hormone problems that cause nipples to leak fluid and male breasts to grow abnormally large.
  • Sometimes causes weight gain and low blood pressure.
  • Mild risk of causing extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • Not a good choice for elderly people who have dementia.
  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
  • Mild to moderate risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • Compared to other antipsychotics, higher risk of hormone problems that cause nipples to leak and male breasts to grow abnormally large.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
Tips from our pharmacists for people taking the medication
InvegaRisperdal
  • It'll take 4 to 6 weeks to see the medication's full effects on thoughts and mood.
  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
  • For the first week, avoid activities like driving that require you to be alert.
  • Don't worry if you see tablet shells in your stool since the medication was already absorbed by your body.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people who have dementia shouldn't take Invega (Paliperidone).
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
Learn more
More about InvegaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Invega (paliperidone)?
Worth itNot sureNot worth it
More about RisperdalSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Risperdal (risperidone)?
Worth itNot sureNot worth it