Compare Invega vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Invega (paliperidone)

Prescription only

Saphris (asenapine)

Prescription only
Helps control your thoughts and mood.

Invega (paliperidone) relieves psychotic symptoms and improves mood.

4.2/ 7 average rating with 34 reviewsforInvega
Treats bipolar disorder and schizophrenia.

While Saphris (asenapine) has fewer side effects compared with other medicines that treat bipolar disorder and schizophrenia, it can be more expensive.

Upsides
  • Won't make you as sleepy as other antipsychotic medicines.
  • If you have heart or kidney problems, this may be a better option than other antipsychotic medicines.
  • The pill and injection form allows for flexible dosing schedule.
  • Saphris (asenapine) can be used to treat bipolar disorder in children age 10 or older, and schizophrenia in children age 12 or older.
  • You don't need water to take Saphris (asenapine); the pill dissolves in your mouth right away.
  • Compared to other medicines, the side effects of Saphris (asenapine) are milder.
Downsides
  • Side-effects of weight gain and hormonal imbalance may be intolerable for younger patients.
  • Frequent blood tests are sometimes required to check how the medicine is affecting your body.
  • Saphris (asenapine) is only available as a brand name.
  • Compared to other medicines, Saphris (asenapine) can cause changes in your hormones and make you sleepy.
  • You have to take Saphris (asenapine) twice a day, which can be hard to remember.
Used for
Dosage forms
  • Pill
  • Injection
  • Dissolving pill
Price
Lowest price near you
$2439.52
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Lowest price near you
$568.43
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Reviews
34 
29%
think this treatment is worth it
32%
think this treatment works well
35%
think this treatment is a hassle

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Side effects
10possible side effects
  • Difficulty controlling movements
    12%
  • Drowsiness
    8%
  • Indigestion
    6%
  • Inability to be still
    6%
  • Nausea
    5%
  • Constipation
    4%
  • Weight gain
    4%
  • Abdominal discomfort
    3%
  • Common cold
    3%
  • Back pain
    3%
See more detailed side effects
10possible side effects
  • Sleepiness
    22%
  • Trouble sleeping
    10%
  • Difficulty controlling movements
    6%
  • Numbness in the mouth
    5%
  • Fatigue
    4%
  • Dizziness
    4%
  • Indigestion
    3%
  • Swelling in the arms and legs
    3%
  • Weight gain
    3%
  • High blood pressure
    3%
See more detailed side effects
Risks and warnings
  • Increased risk of death

    Elderly patients with dementia

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Higher blood sugar and cholesterol and weight gain

    Diabetes

    ...and 1 more risk factors

  • Difficulty concentrating

    Alcohol

    ...and 1 more risk factors

See more detailed risks and warnings
  • Higher risk of death

    People age 65 or older with dementia and psychosis

  • Neuroleptic malignant syndrome

    Taking antipsychotic medications

  • Changes in blood pressure and fainting

    High blood pressure

    ...and 1 more risk factors

See more detailed risks and warnings