Compare Invega vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Invega
(Paliperidone)

Saphris
(Asenapine)

Helps control your thoughts and mood. Invega (Paliperidone) is good for treating psychosis and improving mood. It's more likely to cause hormone problems than other antipsychotics.Coming soon.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.1Invega
Reviews for Invega (Paliperidone)
30%
of people say Invega (Paliperidone) is worth it
33%
say it works well
30%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
InvegaSaphris
  • Abnormally fast heart beat 7%
  • Anxiety 5%
  • Common cold 4%
  • Indigestion 4%
  • Constipation 3%
  • Positional low blood pressure 3%
  • Muscle weakness 3%
  • Headache 2%
  • Nausea 2%
  • Abdominal discomfort 2%
More Invega side effects »

We haven’t found good data for Saphris side effects.

FDA side effect reports for Saphris »
How it works
InvegaSaphris
Invega (Paliperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affect your thoughts and mood.Coming soon.
Type of medication
InvegaSaphris
Antipsychotic
Atypical
Prescription only
Coming soon.
Available as
InvegaSaphris
  • Extended release
  • Injection
  • Pill
Used for (click to learn more)
InvegaSaphris
  • Bipolar I disorder
Risk factors for serious side effects
InvegaSaphris
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Invega (Paliperidone) risks & warnings »
          Coming soon.
          Pregnancy category
          InvegaSaphris
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Invega (Paliperidone) can increase your blood sugar and cholesterol. Invega (Paliperidone) is moderately likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
          No specific sleep-related info.
          Weight
          • Sometimes causes weight gain and low blood pressure.
          • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          No specific weight-related info.
          Upsides and benefits
          InvegaSaphris
          • Effective at relieving psychotic symptoms and relapse rates for people with schizophrenia.
          • Also relieves psychotic symptoms and improves mood for people with schizoaffective disorder.
          • Works just as well as other antipsychotic medicines.
          • Less likely to cause heart or liver problems than some other antipsychotic medications.
          Coming soon.
          Downsides and risks
          InvegaSaphris
          • Invega (Paliperidone) has a high risk of causing hormone problems that cause nipples to leak fluid and male breasts to grow abnormally large.
          • Sometimes causes weight gain and low blood pressure.
          • Mild risk of causing extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
          • You might need routine blood tests to check how the medicine is affecting your body.
          • Not a good choice for elderly people who have dementia.
          • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
          Coming soon.
          Tips from our pharmacists for people taking the medication
          InvegaSaphris
          • It'll take 4 to 6 weeks to see the medication's full effects on thoughts and mood.
          • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
          • For the first week, avoid activities like driving that require you to be alert.
          • Don't worry if you see tablet shells in your stool since the medication was already absorbed by your body.
          • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
          • Elderly people who have dementia shouldn't take Invega (Paliperidone).
          Coming soon.
          Learn more
          More about InvegaSide effectsReviews & ratingsAlternativesFDA package insert
          More about SaphrisSide effectsReviews & ratingsFDA package insert