Compare Invega vs. Zyprexa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Invega
(Paliperidone)

Zyprexa
(Olanzapine)

Helps control your thoughts and mood. Invega (Paliperidone) is good for treating psychosis and improving mood. It's more likely to cause hormone problems than other antipsychotics.Helps control your thoughts and mood. Zyprexa (Olanzapine) is good for treating psychosis, mania, and agitation. More likely to cause weight gain and sleepiness than other antipsychotics.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.1Invega
Reviews for Invega (Paliperidone)
30%
of people say Invega (Paliperidone) is worth it
33%
say it works well
30%
say it's a big hassle
Reviews for Zyprexa (Olanzapine)
45%
+15% vs. Invega (Paliperidone)
53%
+20% vs. Invega (Paliperidone)
47%
17% vs. Invega (Paliperidone)
Side effects
InvegaZyprexa
  • Abnormally fast heart beat 7%
  • Anxiety 5%
  • Common cold 4%
  • Indigestion 4%
  • Constipation 3%
  • Positional low blood pressure 3%
  • Muscle weakness 3%
  • Headache 2%
  • Nausea 2%
  • Abdominal discomfort 2%
More Invega side effects »
  • Relaxation or sleepiness 39%
  • Increased appetite 25%
  • Weight increase 22%
  • Drowsiness 22%
  • Dry mouth 15%
  • Dizziness 12%
  • Muscle weakness 9%
  • Fatigue 8%
  • Constipation 6%
  • Indigestion 6%
More Zyprexa side effects »
How it works
InvegaZyprexa
Invega (Paliperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affect your thoughts and mood.Zyprexa (Olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
InvegaZyprexa
Antipsychotic
Atypical
Prescription only
Antipsychotic
Atypical
Prescription only
Available as
InvegaZyprexa
  • Extended release
  • Injection
  • Pill
  • Dissolving tablet
  • Injection
Used for (click to learn more)
InvegaZyprexa
Risk factors for serious side effects
InvegaZyprexa
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Invega (Paliperidone) risks & warnings »
          • Elderly patients with dementia
              • History of heart problems
              • Drug interactions
                • People with diabetes
                • People with high cholesterol
                • People with diabetes
                • Alcohol
                • Taking other medicines that make you less alert
                  Detailed Zyprexa (Olanzapine) risks & warnings »
                  Pregnancy category
                  InvegaZyprexa
                  CFDA pregnancy category (Weigh risks vs. benefits)

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  See the FDA package insert
                  CFDA pregnancy category (Weigh risks vs. benefits)

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  See the FDA package insert
                  Alcohol
                  No specific alcohol-related info.No specific alcohol-related info.
                  Food
                  • Invega (Paliperidone) can increase your blood sugar and cholesterol. Invega (Paliperidone) is moderately likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Zyprexa (Olanzapine) can increase your blood sugar and cholesterol. Zyprexa (Olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  Kidneys and liver
                  No specific kidneys and liver-related info.No specific kidneys and liver-related info.
                  Sex
                  No specific sex-related info.No specific sex-related info.
                  Sleep
                  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
                  • Can cause dizziness and drowsiness.
                  Weight
                  • Sometimes causes weight gain and low blood pressure.
                  • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  Upsides and benefits
                  InvegaZyprexa
                  • Effective at relieving psychotic symptoms and relapse rates for people with schizophrenia.
                  • Also relieves psychotic symptoms and improves mood for people with schizoaffective disorder.
                  • Works just as well as other antipsychotic medicines.
                  • Less likely to cause heart or liver problems than some other antipsychotic medications.
                  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
                  • Lowers relapse rates for schizophrenia and bipolar disorder.
                  • Antipsychotic medicines are all about equally effective.
                  • Less likely to cause heart problems than some antipsychotics.
                  Downsides and risks
                  InvegaZyprexa
                  • Invega (Paliperidone) has a high risk of causing hormone problems that cause nipples to leak fluid and male breasts to grow abnormally large.
                  • Sometimes causes weight gain and low blood pressure.
                  • Mild risk of causing extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                  • Not a good choice for elderly people who have dementia.
                  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
                  • You might need routine blood tests to check how the medicine is affecting your body.
                  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
                  • Might make you more sleepy than some antipsychotics.
                  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                  • You might need routine blood tests to check how the medicine is affecting your body.
                  Tips from our pharmacists for people taking the medication
                  InvegaZyprexa
                  • It'll take 4 to 6 weeks to see the medication's full effects on thoughts and mood.
                  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
                  • For the first week, avoid activities like driving that require you to be alert.
                  • Don't worry if you see tablet shells in your stool since the medication was already absorbed by your body.
                  • Elderly people who have dementia shouldn't take Invega (Paliperidone).
                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
                  • Can cause dizziness and drowsiness.
                  • For the first week, avoid activities that require you to be alert.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Elderly people with dementia shouldn't take it.
                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                  Learn more
                  More about InvegaSide effectsReviews & ratingsAlternativesFDA package insert
                  More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert