Compare Invirase vs. Crixivan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Invirase (saquinavir)

Prescription only

Crixivan (indinavir)

Prescription only
Works with other medicines to treat HIV infection.

Invirase (saquinavir) is not a first choice medicine for HIV because other medicines similar to Invirase (saquinavir) work better with fewer side effects and with less pills to take every day.

Treats HIV infection.

Crixivan (indinavir) is a good alternative drug used with other medications to treat HIV, but is not a first-choice treatment because of its side effects and many drug interactions.

Upsides
  • If you have trouble swallowing capsules, they can be opened and mixed with syrup or jam.
  • People ages 16 and older can use this medicine.
  • Can be effective at treating HIV infection if other medicines have not worked.
Downsides
  • Have to take at least 4 pills to reach your daily dose, along with all the other medications you are taking for HIV treatment.
  • Invirase (saquinavir) interacts with many other medications. This interaction can be harmful.
  • Can raise your blood sugar and cholesterol levels.
  • If you have a history of heart problems, Invirase (saquinavir) can put you at risk for developing unusual heart rhythms.
  • Only use ritonavir to boost Invirase (saquinavir), not Tybost (cobicistat).
  • Crixivan (indinavir) interacts with many other drugs. Talk to your doctor or pharmacist before starting any new medications.
  • Crixivan (indinavir) can cause kidney stones so it's important to stay hydrated.
  • Crixivan (indinavir) might cause yellowing of the skin or eyes.
  • Crixivan (indinavir) can cause high cholesterol, triglyceride, and blood sugar levels.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$139.2
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Lowest price near you
$113.91
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Side effects
10possible side effects
  • Nausea
    11%
  • Diarrhea
    8%
  • Vomiting
    7%
  • Abdominal pain
    6%
  • Fatigue
    6%
  • Changes in fat distribution
    5%
  • Pneumonia
    5%
  • Diabetes or increased blood sugar
    3%
  • Fever
    3%
  • Bronchitis
    3%
See more detailed side effects
10possible side effects
  • Abdominal pain
    17%
  • Kidney stones
    12%
  • Nausea
    12%
  • Elevated serum bilirubin
    12%
  • Vomiting
    8%
  • Back pain
    8%
  • Headache
    5%
  • Itching
    4%
  • Diarrhea
    3%
  • Acid regurgitation
    3%
See more detailed side effects
Risks and warnings
  • Heart rhythm problems

    Use with other QT or PR prolonging drugs

    ...and 2 more risk factors

  • Liver damage

    History of liver damage

    ...and 2 more risk factors

  • New or worsening diabetes

    Use of protease inhibitors

    ...and 1 more risk factors

  • Immune reconstitution syndrome

    HIV

    ...and 3 more risk factors

See more detailed risks and warnings
  • New onset or worsened diabetes

    Use of protease inhibitors

    ...and 1 more risk factors

  • Liver damage

    History of liver damage

  • Kidney stones

    Children

    ...and 1 more risk factors

  • Fat redistribution

    HIV treatment

See more detailed risks and warnings