Compare Invirase vs. Kaletra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Invirase (saquinavir)

Prescription only
Works with other medicines to treat HIV infection.

Invirase (saquinavir) is not a first choice medicine for HIV because other medicines similar to Invirase (saquinavir) work better with fewer side effects and with less pills to take every day.

Treats HIV infection.

Kaletra (lopinavir / ritonavir) is not commonly used to treat HIV because of its side effects and the number of pills you have to take daily.

Upsides
  • If you have trouble swallowing capsules, they can be opened and mixed with syrup or jam.
  • People ages 16 and older can use this medicine.
  • Kaletra (lopinavir / ritonavir) can be taken once or twice daily.
  • Tablets can be taken with or without food.
  • An oral solution is available if tablets are hard to swallow.
Downsides
  • Have to take at least 4 pills to reach your daily dose, along with all the other medications you are taking for HIV treatment.
  • Invirase (saquinavir) interacts with many other medications. This interaction can be harmful.
  • Can raise your blood sugar and cholesterol levels.
  • If you have a history of heart problems, Invirase (saquinavir) can put you at risk for developing unusual heart rhythms.
  • Only use ritonavir to boost Invirase (saquinavir), not Tybost (cobicistat).
  • Has more side-effects compared to newer medicines that work like it.
  • You may have to take up to 4 tablets to meet your required daily dose.
  • Interacts with many other medicines and supplements.
  • Can increase your risk for a heart attack.
Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
Lowest price near you
$139.2
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Lowest price near you
$176.1
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Side effects
10possible side effects
  • Nausea
    11%
  • Diarrhea
    8%
  • Vomiting
    7%
  • Abdominal pain
    6%
  • Fatigue
    6%
  • Changes in fat distribution
    5%
  • Pneumonia
    5%
  • Diabetes or increased blood sugar
    3%
  • Fever
    3%
  • Bronchitis
    3%
See more detailed side effects
10possible side effects
  • Diarrhea
    20%
  • Upper respiratory tract infection
    14%
  • Nausea
    10%
  • Fatigue and weakness
    8%
  • Lower respiratory tract infection
    8%
  • Vomiting
    7%
  • High cholesterol
    7%
  • Bone, joint and back pain
    7%
  • Abdominal pain
    6%
  • High fats
    6%
See more detailed side effects
Risks and warnings
  • Heart rhythm problems

    Use with other QT or PR prolonging drugs

    ...and 2 more risk factors

  • Liver damage

    History of liver damage

    ...and 2 more risk factors

  • New or worsening diabetes

    Use of protease inhibitors

    ...and 1 more risk factors

  • Immune reconstitution syndrome

    HIV

    ...and 3 more risk factors

See more detailed risks and warnings
  • Liver damage

    History of liver damage

    ...and 1 more risk factors

  • Heart (atrioventricular) block

    Use with other QT or PR prolonging drugs

    ...and 2 more risk factors

  • Immune recovery syndrome

    HIV

    ...and 3 more risk factors

  • New or worsening diabetes

    Use of protease inhibitors

    ...and 1 more risk factors

  • Pancreatitis

    Advanced HIV disease

    ...and 1 more risk factors

See more detailed risks and warnings