Compare Invokamet vs. Glucovance

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Invokamet (canagliflozin / metformin)

Prescription only

Glyburide / Metformin

Prescription only
Lowers blood sugar.

Invokamet (canagliflozin / metformin) is a combination of 2 medicines that can lower your blood sugars, but it still has to be taken twice daily.

Lowers blood sugar.

Glyburide / Metformin is an effective combination medicine for lowering blood sugar, but it is likely to cause diarrhea in the first few weeks.

Upsides
  • Combines 2 effective anti-diabetes medicines into one pill so you don't have to take them separately.
  • Does not cause weight gain unlike other anti-diabetic medicines.
  • Not as likely to cause hypoglycemia (low blood sugar)
  • Glyburide / Metformin effectively lowers blood sugar levels more so than if each of the individual medicines it contains are taken alone.
  • Protects your organs and blood vessels from the harmful effects of high blood sugar levels.
  • Can potentially lower your "bad cholesterol" levels.
  • Glyburide / Metformin is available in a generic form and is cheaper than many other combination diabetes medicines.
Downsides
  • Not a good option if you have worsening kidney function such as those age 65 years and up.
  • May cause increased urination.
  • More likely to cause broken bones and yeast and urinary tract infections.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • Glyburide / Metformin is likely to cause nausea, stomach upset, or diarrhea in the first few weeks.
  • Not a good treatment option for those with kidney and/or liver problems.
  • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
  • Can cause some weight gain.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$444.76
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Lowest price near you
$14.4
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Side effects
9possible side effects
  • Yeast infection in women
    11%
  • Urinary tract infections
    6%
  • Increased urination
    5%
  • Yeast infection in men
    4%
  • Thirst
    3%
  • Vaginal itching
    2%
  • Constipation
    2%
  • Nausea
    2%
  • Abdominal pain
    2%
See more detailed side effects
6possible side effects
  • Upper respiratory infection
    17%
  • Diarrhea
    17%
  • Headache
    9%
  • Nausea/vomiting
    8%
  • Stomach pain
    7%
  • Dizziness
    6%
See more detailed side effects
Risks and warnings
  • Acid buildup in the blood

    Kidney problems

    ...and 5 more risk factors

  • Low blood pressure (hypotension)

    Over age 65

    ...and 4 more risk factors

  • Bone fractures

    Low blood pressure

    ...and 1 more risk factors

  • Kidney damage

    History of kidney damage

    ...and 3 more risk factors

  • Genital yeast infection and urinary tract infection

    History of urinary tract infections

    ...and 2 more risk factors

  • Low blood sugars

    Taking other diabetic medications

    ...and 2 more risk factors

See more detailed risks and warnings
  • Lactic acid build up in blood

    History of kidney problems

    ...and 5 more risk factors

  • Low blood sugar

    Skipping meals or having inconsistent meal times

    ...and 4 more risk factors

  • Severe allergic reaction

    History of allergy to sulfa-containing medicine

  • Breakdown of red blood cells

    People with G6PD deficiency

See more detailed risks and warnings