Compare Invokamet vs. Glucovance

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Invokamet
(canagliflozin / metformin)

glyburide / metformin

Lowers blood sugar. Invokamet (canagliflozin / metformin) is a combination of 2 medicines that can lower your blood sugars, but it still has to be taken twice daily.Lowers blood sugar. Glyburide / Metformin is an effective combination medicine for lowering blood sugar, but it is likely to cause diarrhea in the first few weeks.
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Best available price for 120 (5mg/500mg) tablets of glucovance
Reviews & ratings
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Have you used Invokamet (canagliflozin / metformin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Glyburide / Metformin?
Worth itNot sureNot worth it
Side effects
InvokametGlucovance
  • Yeast infection in women 8%
  • Urinary tract infections 2%
  • Increased urination 4%
  • Yeast infection in men 3%
  • Thirst 3%
  • Vaginal itching 2%
  • Constipation 1%
  • Abdominal pain 1%
More Invokamet side effects »
  • Upper respiratory infection 3%
  • Diarrhea 11%
  • Nausea/vomiting 2%
  • Stomach pain 3%
  • Dizziness 2%
  • Gastrointestinal side effects (diarrhea, nausea/vomiting, and stomach pain) 8%
  • Low blood sugar 8%
More Glucovance side effects »
How it works
InvokametGlucovance
Invokamet (canagliflozin / metformin) is a combination of anti-diabetes medicines. Metformin lowers blood sugar by enhancing your body's response to insulin, while canagliflozin increases your body's secretion of sugar through the urine.Glyburide / Metformin combines 2 prescription medicines (glyburide and metformin) into 1 pill to help treat diabetes. Glyburide stimulates your body to release insulin to lower blood sugar. Metformin helps your body use its own insulin more effectively as well as lowers the amount of sugar your body naturally makes and absorbs from food.
Type of medication
InvokametGlucovance
Prescription onlyPrescription only
Available as
InvokametGlucovance
  • Pill
  • Pill
Used for
InvokametGlucovance
Risk factors for serious side effects
InvokametGlucovance
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Contrast dye for procedure
  • Surgery
Detailed Invokamet (canagliflozin / metformin) risks & warnings »
  • History of kidney problems
  • History of liver problems
  • Those with congestive heart failure
  • Using contrast dye for procedures
  • Undergoing surgery
Detailed Glyburide / Metformin risks & warnings »
Pregnancy
Alcohol
InvokametGlucovance
No alcohol related info.
  • Limit the amount of alcohol you drink while taking Glyburide / Metformin.
  • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
Food
InvokametGlucovance
  • Take with meals to avoid an upset stomach.
No food related info.
Kidneys and liver
InvokametGlucovance
  • Not a good option if you have worsening kidney function such as those age 65 years and up.
  • Not a good treatment option for those with kidney and/or liver problems.
Pain
InvokametGlucovance
  • Invokamet (canagliflozin / metformin) can, in very rare cases, hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or are taking medicines for blood pressure or pain like NSAIDs. Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Invokamet (canagliflozin / metformin).
No pain related info.
Weight
InvokametGlucovance
  • Does not cause weight gain unlike other anti-diabetic medicines.
  • Can cause some weight gain.
Upsides and benefits
InvokametGlucovance
  • Combines 2 effective anti-diabetes medicines into one pill so you don't have to take them separately.
  • Does not cause weight gain unlike other anti-diabetic medicines.
  • Not as likely to cause hypoglycemia (low blood sugar)
  • Glyburide / Metformin effectively lowers blood sugar levels more so than if each of the individual medicines it contains are taken alone.
  • Protects your organs and blood vessels from the harmful effects of high blood sugar levels.
  • Can potentially lower your "bad cholesterol" levels.
  • Glyburide / Metformin is available in a generic form and is cheaper than many other combination diabetes medicines.
Downsides and risks
InvokametGlucovance
  • Not a good option if you have worsening kidney function such as those age 65 years and up.
  • May cause increased urination.
  • More likely to cause broken bones and yeast and urinary tract infections.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • Glyburide / Metformin is likely to cause nausea, stomach upset, or diarrhea in the first few weeks.
  • Not a good treatment option for those with kidney and/or liver problems.
  • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
  • Can cause some weight gain.
Tips from our pharmacists for people taking the medication
InvokametGlucovance
  • Take with meals to avoid an upset stomach.
  • Practice good hygiene to prevent yeast infections.
  • Can cause dehydration so be sure to drink plenty of fluids.
  • Make sure to continue a healthy diet and lifetyle.
  • Check your blood sugar regularly.
  • Wear sunscreen and appropriate clothing to protect yourself from the sun.
  • Take the medicine with meals to prevent an upset stomach.
  • Tell your doctor right away if you experience rapid breathing, ongoing nausea, vomiting, or stomach pain.
  • Limit the amount of alcohol you drink while taking Glyburide / Metformin.
Learn more
More about InvokametSide effectsAlternativesFDA package insert
Have you used Invokamet (canagliflozin / metformin)?
Worth itNot sureNot worth it
More about GlucovanceSide effectsAlternativesFDA package insert
Have you used Glyburide / Metformin?
Worth itNot sureNot worth it