Compare Invokana vs. Actos

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Invokana
(Canagliflozin)

Actos
(Pioglitazone)

Lowers your blood sugar. Invokana (Canagliflozin) helps lower blood sugar for people with diabetes but it can increase the chance of a yeast infection and can be expensive.Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Invokana (Canagliflozin)?
Worth itNot sureNot worth it
Reviews for Actos (Pioglitazone)
42%
26% vs. Invokana (Canagliflozin)
31%
22% vs. Invokana (Canagliflozin)
21%
5% vs. Invokana (Canagliflozin)
173 reviews
Have you used Actos (Pioglitazone)?
Worth itNot sureNot worth it
Side effects
InvokanaActos
  • Female genital mycotic infections 8%
  • Increased urination 4%
  • Male genital mycotic infections 3%
  • Urinary tract infections 2%
  • Low blood sugar 1%
  • Constipation 1%
More Invokana side effects »
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Sore throat 4%
  • Cardiac failure 2%
  • Muscle pain 2%
  • Headache 2%
  • Back pain 1%
  • Sinus inflammation 1%
More Actos side effects »
How it works
InvokanaActos
Invokana (Canagliflozin) is an anti-diabetes medication. It lowers blood sugar by causing your body to get rid of sugar in your urine.Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.
Type of medication
InvokanaActos
Anti-diabetic
SGLT2 inhibitor
Prescription only
Anti-diabetic
Thiazoladinedione
Prescription only
Available as
InvokanaActos
  • Pill
  • Pill
Used for (click to learn more)
InvokanaActos
Risk factors for serious side effects
InvokanaActos
  • Over age 65
  • Kidney disease
  • Taking blood pressure medications
  • Kidney disease
  • Taking blood pressure medications
  • Using insulin
  • Using medications that increase the amount of insulin in your body (glipizide, glyburide or glimepiride)
  • Women
  • Uncircumcised men
      Detailed Invokana (Canagliflozin) risks & warnings »
      • Heart failure diagnosis
        • Current liver problems
          • Female
          Detailed Actos (Pioglitazone) risks & warnings »
          Pregnancy

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Food
          InvokanaActos
          • Take Invokana (Canagliflozin) before your first meal of the day.
          • Eat regular, balanced meals to avoid low blood sugar.
          No food related info.
          Weight
          InvokanaActos
          No weight related info.
          • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
          • Can cause weight gain, headache, and fluid retention.
          Upsides and benefits
          InvokanaActos
          • Lowers A1c levels by 1% (A1c measures your average blood sugar over time.)
          • Prevents the harmful effects of high sugar levels on your organs.
          • Can be taken by mouth, only once a day, compared to other diabetes medications that require an injection.
          • Has a lower chance of causing low blood sugar than medications like glyburide or insulin.
          • Also available as a combination drug with metformin (Invokamet).
          • Oral blood sugar-lowering medicine.
          • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
          • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
          • Rarely causes low blood sugar.
          Downsides and risks
          InvokanaActos
          • Only lowers A1c levels by 1%, which may not be enough to get your blood sugar in the safe range.
          • Not available as a generic.
          • Many other diabetes medications work as well and are cheaper.
          • Can cause increased urination, thirst, and increased likelihood to get yeast infections.
          • Not considered the best first choice drug to help lower blood sugar.
          • May take several weeks to lower blood sugar.
          • You have to check your blood sugar regularly with this medicine.
          • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
          • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
          • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
          • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
          • Slightly raises the risk of bladder cancer.
          Tips from our pharmacists for people taking the medication
          InvokanaActos
          • Take Invokana (Canagliflozin) before your first meal of the day.
          • Drink plenty of fluids since Invokana (Canagliflozin) can make you thirsty.
          • Eat regular, balanced meals to avoid low blood sugar.
          • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure the medication is working well. Some people may need to test more often.
          • Takes several weeks to see full effect on blood sugar control.
          • Can cause weight gain, headache, and fluid retention.
          • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
          • Not recommended for patients with certain heart problems.
          • Check your blood sugar regularly.
          Learn more
          More about InvokanaSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Invokana (Canagliflozin)?
          Worth itNot sureNot worth it
          More about ActosSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Actos (Pioglitazone)?
          Worth itNot sureNot worth it