Compare Invokana vs. Glucotrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Invokana
(canagliflozin)

Glucotrol
(glipizide)

Lowers your blood sugar. Invokana (Canagliflozin) helps lower blood sugar for people with diabetes but it can increase the chance of a yeast infection and can be expensive.Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
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Prices and coupon for 30 (300mg) tablets of canagliflozin
Coupons for
Prices and coupon for 60 (5mg) tablets of glipizide
Reviews & ratings
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Have you used Invokana (canagliflozin)?
Worth itNot sureNot worth it
Reviews for Glucotrol (glipizide)
50%
-17% worse vs. Invokana (canagliflozin)
32%
-24% worse vs. Invokana (canagliflozin)
19%
Same vs. Invokana (canagliflozin)
332 reviews
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
Side effects
InvokanaGlucotrol
  • Female genital mycotic infections 7%
  • Urinary tract infections 2%
  • Increased urination 4%
  • Volume depletion 5%
  • Male genital mycotic infections 3%
  • Hypersensitivity reaction 4%
  • Low blood sugar 1%
  • Thirst 3%
  • Vulvovaginal pruritus 3%
More Invokana side effects »
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Drowsiness 2%
More Glucotrol side effects »
How it works
InvokanaGlucotrol
Invokana (Canagliflozin) is an anti-diabetes medication. It lowers blood sugar by causing your body to get rid of sugar in your urine.Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.
Type of medication
InvokanaGlucotrol
Prescription only
Prescription only
Available as
InvokanaGlucotrol
  • Pill
  • Pill
  • Extended release
Used for
InvokanaGlucotrol
Risk factors for serious side effects
InvokanaGlucotrol
  • Over age 65
  • Kidney disease
  • Taking blood pressure medications
  • Kidney disease
  • Taking blood pressure medications
  • Using insulin
  • Using medications that increase the amount of insulin in your body (glipizide, glyburide or glimepiride)
  • Women
  • Uncircumcised men
      Detailed Invokana (canagliflozin) risks & warnings »
        • Use of other blood sugar lowering medicines
        • Alcohol
        • Intense physical activity
        • History of sulfa allergies
        Detailed Glucotrol (glipizide) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Alcohol
        InvokanaGlucotrol
        No alcohol related info.
        • Avoid drinking alcohol.
        Food
        InvokanaGlucotrol
        • Take Invokana (Canagliflozin) before your first meal of the day.
        • Eat regular, balanced meals to avoid low blood sugar.
        • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
        • Eat regular, balanced meals to avoid low blood sugar.
        Kidneys and liver
        InvokanaGlucotrol
        No kidneys and liver related info.
        • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
        Weight
        InvokanaGlucotrol
        No weight related info.
        • Can cause mild weight gain (2 to 3 pounds).
        • Can cause weight gain, dizziness, or stomach upset.
        Upsides and benefits
        InvokanaGlucotrol
        • Lowers A1c levels by 1% (A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs.
        • Can be taken by mouth, only once a day, compared to other diabetes medications that require an injection.
        • Has a lower chance of causing low blood sugar than medications like glyburide or insulin.
        • Also available as a combination drug with metformin (Invokamet).
        • Oral blood sugar-lowering medicine.
        • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
        • One of the least expensive diabetes medicines.
        Downsides and risks
        InvokanaGlucotrol
        • Only lowers A1c levels by 1%, which may not be enough to get your blood sugar in the safe range.
        • Not available as a generic.
        • Many other diabetes medications work as well and are cheaper.
        • Can cause increased urination, thirst, and increased likelihood to get yeast infections.
        • Not considered the best first choice drug to help lower blood sugar.
        • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
        • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
        • Can cause mild weight gain (2 to 3 pounds).
        • Loses effectiveness over time or as your body stops making insulin.
        • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
        Tips from our pharmacists for people taking the medication
        InvokanaGlucotrol
        • Take Invokana (Canagliflozin) before your first meal of the day.
        • Drink plenty of fluids since Invokana (Canagliflozin) can make you thirsty.
        • Eat regular, balanced meals to avoid low blood sugar.
        • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure the medication is working well. Some people may need to test more often.
        • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
        • Can cause weight gain, dizziness, or stomach upset.
        • Avoid drinking alcohol.
        • Eat regular, balanced meals to avoid low blood sugar.
        • Check your blood sugar regularly.
        Learn more
        More about InvokanaSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Invokana (canagliflozin)?
        Worth itNot sureNot worth it
        More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Glucotrol (glipizide)?
        Worth itNot sureNot worth it