Compare Invokana vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Invokana (canagliflozin)

Prescription only

Diabeta (glyburide)

Prescription only
Lowers blood sugar.

Invokana (canagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.

5.5/ 7 average rating with 27 reviewsforInvokana
Lowers blood sugar.

Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.

4.4/ 7 average rating with 110 reviewsforglyburide
Upsides
  • Lowers A1C (blood sugar) levels by 1%.
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Less likely to cause low blood sugar than other diabetes medicines.
  • Also available as a combination drug with metformin (Invokamet).
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
Downsides
  • You're more likely to have broken bones, yeast infections and urinary tract infections with Invokana (canagliflozin).
  • There's a rare but serious risk of leg and foot amputations with Invokana (canagliflozin). Talk to your doctor if you develop new pain or infections in your feet.
  • Not for people with severe kidney problems.
  • Can raise your cholesterol.
  • Avoid if you are a heavy drinker of alcohol.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$444.76
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Lowest price near you
$10
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Reviews
27 
67%
think this treatment is worth it
56%
think this treatment works well
19%
think this treatment is a hassle

Have you used Invokana (canagliflozin)?

Leave a review
110 
45%
think this treatment is worth it
34%
think this treatment works well
21%
think this treatment is a hassle

Have you used Diabeta (glyburide)?

Leave a review
Side effects
9possible side effects
  • Yeast infection in women
    11%
  • Urinary tract infections
    6%
  • Increased urination
    5%
  • Yeast infection in men
    4%
  • Thirst
    3%
  • Vaginal itching
    2%
  • Constipation
    2%
  • Nausea
    2%
  • Abdominal pain
    2%
See more detailed side effects
The Diabeta (glyburide) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Increased risk of leg and foot amputations

    History of amputations 

    ...and 3 more risk factors

  • Kidney damage and low blood pressure

    History of kidney damage

    ...and 3 more risk factors

  • Low blood sugar (hypoglycemia)

    Taking medicines for diabetes

  • Increased acid and ketones in the blood

    Long periods of fasting

    ...and 3 more risk factors

See more detailed risks and warnings
  • Low blood sugar

    Over age 65

    ...and 4 more risk factors

  • Severe allergic reactions

    History of sulfa allergies

See more detailed risks and warnings