Compare Invokana vs. Glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Invokana
(Canagliflozin)

Diabeta
(Glyburide)

Lowers your blood sugar. Invokana (Canagliflozin) helps lower blood sugar for people with diabetes but it can increase the chance of a yeast infection and can be expensive.Lowers blood sugar. Glyburide is a very effective oral blood sugar-lowering medicine, but has more side effects and restrictions compared to other medicines in this class (sulfonylureas).
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Reviews & ratings
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Have you used Invokana (Canagliflozin)?
Worth itNot sureNot worth it
Reviews for Diabeta (Glyburide)
46%
22% vs. Invokana (Canagliflozin)
33%
20% vs. Invokana (Canagliflozin)
20%
4% vs. Invokana (Canagliflozin)
109 reviews
Have you used Diabeta (Glyburide)?
Worth itNot sureNot worth it
Side effects
InvokanaGlyburide
  • Female genital mycotic infections 8%
  • Increased urination 4%
  • Male genital mycotic infections 3%
  • Urinary tract infections 2%
  • Low blood sugar 1%
  • Constipation 1%
More Invokana side effects »

The Glyburide FDA package insert doesn’t have numbers about how common side effects are.

More about Glyburide side effects »
How it works
InvokanaGlyburide
Invokana (Canagliflozin) is an anti-diabetes medication. It lowers blood sugar by causing your body to get rid of sugar in your urine.Glyburide is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.
Type of medication
InvokanaGlyburide
Anti-diabetic
SGLT2 inhibitor
Prescription only
Anti-diabetic
Sulfonylurea
Prescription only
Available as
InvokanaGlyburide
  • Pill
  • Pill
Used for (click to learn more)
InvokanaGlyburide
Risk factors for serious side effects
InvokanaGlyburide
  • Over age 65
  • Kidney disease
  • Taking blood pressure medications
  • Kidney disease
  • Taking blood pressure medications
  • Using insulin
  • Using medications that increase the amount of insulin in your body (glipizide, glyburide or glimepiride)
  • Women
  • Uncircumcised men
      Detailed Invokana (Canagliflozin) risks & warnings »
        • Elderly
        • Use of other blood sugar lowering medicines
        • Alcohol
        • Intense physical activity
        • History of sulfa allergies
        Detailed Diabeta (Glyburide) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Alcohol
        InvokanaGlyburide
        No alcohol related info.
        • Avoid drinking alcohol.
        Food
        InvokanaGlyburide
        • Take Invokana (Canagliflozin) before your first meal of the day.
        • Eat regular, balanced meals to avoid low blood sugar.
        • Eat regular, balanced meals to avoid low blood sugar.
        Kidneys and liver
        InvokanaGlyburide
        No kidneys and liver related info.
        • Not a good choice for people with kidney problems because it's processed by the kidneys.
        Weight
        InvokanaGlyburide
        No weight related info.
        • Can cause mild weight gain (2 to 3 pounds).
        • Can cause weight gain, dizziness, or stomach upset.
        Upsides and benefits
        InvokanaGlyburide
        • Lowers A1c levels by 1% (A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs.
        • Can be taken by mouth, only once a day, compared to other diabetes medications that require an injection.
        • Has a lower chance of causing low blood sugar than medications like glyburide or insulin.
        • Also available as a combination drug with metformin (Invokamet).
        • Oral blood sugar-lowering medicine.
        • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        • One of the least expensive diabetes medicines.
        Downsides and risks
        InvokanaGlyburide
        • Only lowers A1c levels by 1%, which may not be enough to get your blood sugar in the safe range.
        • Not available as a generic.
        • Many other diabetes medications work as well and are cheaper.
        • Can cause increased urination, thirst, and increased likelihood to get yeast infections.
        • Not considered the best first choice drug to help lower blood sugar.
        • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
        • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
        • Can cause mild weight gain (2 to 3 pounds).
        • Not preferred for people 65 years or older since it can cause prolonged low blood sugar (more than 12 hours).
        • Not a good choice for people with kidney problems because it's processed by the kidneys.
        • Loses effectiveness over time or as your body stops making insulin.
        Tips from our pharmacists for people taking the medication
        InvokanaGlyburide
        • Take Invokana (Canagliflozin) before your first meal of the day.
        • Drink plenty of fluids since Invokana (Canagliflozin) can make you thirsty.
        • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure the medication is working well. Some people may need to test more often.
        • Eat regular, balanced meals to avoid low blood sugar.
        • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
        • Can cause weight gain, dizziness, or stomach upset.
        • Avoid drinking alcohol.
        • Check your blood sugar regularly.
        • Eat regular, balanced meals to avoid low blood sugar.
        Learn more
        More about InvokanaSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Invokana (Canagliflozin)?
        Worth itNot sureNot worth it
        More about GlyburideSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Diabeta (Glyburide)?
        Worth itNot sureNot worth it