Compare Invokana vs. Invokamet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Invokana
(canagliflozin)

Invokamet
(canagliflozin / metformin)

Lowers blood sugar. Invokana (canagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.Lowers blood sugar. Invokamet (canagliflozin / metformin) is a combination of 2 medicines that can lower your blood sugars, but it still has to be taken twice daily.
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Best available price for 30 (300mg) tablets of invokana
Reviews & ratings
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Filter group. All currently selected
5.52Invokana
Reviews for Invokana
67%
of people (All ages) say Invokana is worth it
56%
say it works well
19%
say it's a big hassle
Have you used Invokana (canagliflozin)?
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Have you used Invokamet (canagliflozin / metformin)?
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Side effects
InvokanaInvokamet
  • Yeast infection in women 8%
  • Urinary tract infections 2%
  • Increased urination 4%
  • Yeast infection in men 3%
  • Thirst 3%
  • Vaginal itching 2%
  • Constipation 1%
  • Abdominal pain 1%
More Invokana side effects »
  • Yeast infection in women 8%
  • Urinary tract infections 2%
  • Increased urination 4%
  • Yeast infection in men 3%
  • Thirst 3%
  • Vaginal itching 2%
  • Constipation 1%
  • Abdominal pain 1%
More Invokamet side effects »
How it works
InvokanaInvokamet
Invokana (canagliflozin) is an anti-diabetes medication. It lowers blood sugar by causing your body to get rid of sugar in your urine.Invokamet (canagliflozin / metformin) is a combination of anti-diabetes medicines. Metformin lowers blood sugar by enhancing your body's response to insulin, while canagliflozin increases your body's secretion of sugar through the urine.
Type of medication
InvokanaInvokamet
Prescription onlyPrescription only
Available as
InvokanaInvokamet
  • Pill
  • Pill
Used for
InvokanaInvokamet
Risk factors for serious side effects
InvokanaInvokamet
  • History of amputations 
  • Peripheral vascular disease (narrowed blood vessels)
  • Nerve problems
  • Diabetic foot ulcers 
  • History of kidney damage
Detailed Invokana (canagliflozin) risks & warnings »
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Contrast dye for procedure
  • Surgery
Detailed Invokamet (canagliflozin / metformin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
InvokanaInvokamet
  • Avoid if you are a heavy drinker of alcohol.
No alcohol related info.
Food
InvokanaInvokamet
  • Take once daily before your first meal of the day.
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Take with meals to avoid an upset stomach.
Kidneys and liver
InvokanaInvokamet
  • Not for people with severe kidney problems.
  • Not a good option if you have worsening kidney function such as those age 65 years and up.
Pain
InvokanaInvokamet
  • Rarely, Invokana (canagliflozin) can hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or take certain medicines for blood pressure or anti-inflammatories (NSAIDs). Invokana (canagliflozin) can also lower your blood pressure since it makes you urinate more. Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Invokana (canagliflozin). Make sure to stay hydrated to prevent low blood pressure and kidney problems.
  • Invokamet (canagliflozin / metformin) can, in very rare cases, hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or are taking medicines for blood pressure or pain like NSAIDs. Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Invokamet (canagliflozin / metformin).
Weight
InvokanaInvokamet
No weight related info.
  • Does not cause weight gain unlike other anti-diabetic medicines.
Upsides and benefits
InvokanaInvokamet
  • Lowers A1C (blood sugar) levels by 1%.
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Less likely to cause low blood sugar than other diabetes medicines.
  • Also available as a combination drug with metformin (Invokamet).
  • Combines 2 effective anti-diabetes medicines into one pill so you don't have to take them separately.
  • Does not cause weight gain unlike other anti-diabetic medicines.
  • Not as likely to cause hypoglycemia (low blood sugar)
Downsides and risks
InvokanaInvokamet
  • You're more likely to have broken bones, yeast infections and urinary tract infections with Invokana (canagliflozin).
  • There's a rare but serious risk of leg and foot amputations with Invokana (canagliflozin). Talk to your doctor if you develop new pain or infections in your feet.
  • Not for people with severe kidney problems.
  • Can raise your cholesterol.
  • Avoid if you are a heavy drinker of alcohol.
  • Not a good option if you have worsening kidney function such as those age 65 years and up.
  • May cause increased urination.
  • More likely to cause broken bones and yeast and urinary tract infections.
Tips from our pharmacists for people taking the medication
InvokanaInvokamet
  • Take once daily before your first meal of the day.
  • Invokana (canagliflozin) can cause you to urinate more, so be sure to stay hydrated.
  • Can cause genital yeast infections in females and males.
  • Can cause urinary tract infections (UTI).
  • Can cause low blood sugar, so make sure to check your blood sugar if you don't feel well.
  • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Invokana (canagliflozin).
  • Take with meals to avoid an upset stomach.
  • Practice good hygiene to prevent yeast infections.
  • Can cause dehydration so be sure to drink plenty of fluids.
  • Make sure to continue a healthy diet and lifetyle.
Learn more
More about InvokanaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Invokana (canagliflozin)?
Worth itNot sureNot worth it
More about InvokametSide effectsAlternativesFDA package insert
Have you used Invokamet (canagliflozin / metformin)?
Worth itNot sureNot worth it