Compare Invokana vs. Metformin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Invokana
(Canagliflozin)

Glucophage
(Metformin)

Lowers your blood sugar. Invokana (Canagliflozin) helps lower blood sugar for people with diabetes but it can increase the chance of a yeast infection and can be expensive.Lowers blood sugar. Glucophage (Metformin) is a very effective medicine to lower blood sugar and the risk of complications and death from diabetes, but it's likely to cause diarrhea for the first few weeks.
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Reviews & ratings
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Reviews for Glucophage (Metformin)
65%
3% vs. Invokana (Canagliflozin)
46%
7% vs. Invokana (Canagliflozin)
16%
Same vs. Invokana (Canagliflozin)
Side effects
InvokanaMetformin
  • Female genital mycotic infections 8%
  • Increased urination 4%
  • Male genital mycotic infections 3%
  • Urinary tract infections 2%
  • Low blood sugar 1%
  • Constipation 1%
More Invokana side effects »
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Passing gas 6%
  • Indigestion 3%
  • Muscle weakness 3%
  • Abdominal discomfort 1%
  • Headache 1%
More Metformin side effects »
How it works
InvokanaMetformin
Invokana (Canagliflozin) is an anti-diabetes medication. It lowers blood sugar by causing your body to get rid of sugar in your urine.Glucophage (Metformin) is an anti-diabetic drug. It lowers sugar production in your body, decreases sugar absorption in your intestines, and makes your body more sensitive to insulin.
Type of medication
InvokanaMetformin
Anti-diabetic
SGLT2 inhibitor
Prescription only
Anti-diabetic
Biguanide
Prescription only
Available as
InvokanaMetformin
  • Pill
  • Pill
  • Extended release
  • Liquid
Used for (click to learn more)
InvokanaMetformin
Risk factors for serious side effects
InvokanaMetformin
  • Over age 65
  • Kidney disease
  • Taking blood pressure medications
  • Kidney disease
  • Taking blood pressure medications
  • Using insulin
  • Using medications that increase the amount of insulin in your body (glipizide, glyburide or glimepiride)
  • Women
  • Uncircumcised men
      Detailed Invokana (Canagliflozin) risks & warnings »
      • Kidney problems
      • Liver problems
      • Congestive heart failure
      • Using contrast dye for procedures
      • Surgery
      • Alcohol use
        Detailed Glucophage (Metformin) risks & warnings »
        Pregnancy category
        InvokanaMetformin
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        • Take Invokana (Canagliflozin) before your first meal of the day.
        • Eat regular, balanced meals to avoid low blood sugar.
        • If you're taking Invokana (Canagliflozin) and you're on insulin or other drugs that increase the amount of insulin in your body, you can be at risk for having low blood sugar. Your doctor might have to adjust your dose of these other medications. Always have glucose tablets or another blood sugar rescue food with you in case you get low blood sugar. Good blood sugar rescue foods are 1/2 cup of orange juice, regular (not diet) soda, and 3 teaspoons of table sugar (or 3 sugar packets).
        • Always take it with food or switch to the extended release version to avoid upset stomach.
        Kidneys and liver
        • People on Invokana (Canagliflozin) have reported having low blood pressure. You are more likely to get this if you are over 65, have kidney disease, or taking blood pressure medications called ACE inhibitors or ARBs. Talk to your doctor since they might have to adjust your medications. Be very careful getting up from either sitting or lying down since you can feel dizzy the first few days you take Invokana (Canagliflozin).
        • People on Invokana (Canagliflozin) can get high potassium levels in the blood, especially if you have kidney disease or taking blood pressure medications that keep your potassium levels high. Your doctor can monitor your blood for potassium. Talk to your doctor if you suddenly feel weakness in your muscles, numbness or tingling, or if your heart starts beating irregularly.
        • People with poor kidney function can't use it.
        • Glucophage (Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucophage (Metformin). It may not be a good choice for people with kidney problems. Glucophage (Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.
        • Unlike some diabetes medicines, doesn't cause weight gain or low blood sugar.
        Upsides and benefits
        InvokanaMetformin
        • Lowers A1c levels by 1% (A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs.
        • Can be taken by mouth, only once a day, compared to other diabetes medications that require an injection.
        • Has a lower chance of causing low blood sugar than medications like glyburide or insulin.
        • Also available as a combination drug with metformin (Invokamet).
        • Oral blood sugar-lowering medicine.
        • A common first treatment for people with newly-diagnosed Type 2 diabetes.
        • The only oral diabetes medicine that lowers complications and deaths from conditions related to diabetes.
        • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        • Also lowers certain lipid (fat and cholesterol) levels.
        • Unlike some diabetes medicines, doesn't cause weight gain or low blood sugar.
        • You don't have to check your blood sugar every day with this medicine.
        • One of the least expensive diabetes medicines.
        Downsides and risks
        InvokanaMetformin
        • Only lowers A1c levels by 1%, which may not be enough to get your blood sugar in the safe range.
        • Not available as a generic.
        • Many other diabetes medications work as well and are cheaper.
        • Can cause increased urination, thirst, and increased likelihood to get yeast infections.
        • Not considered the best first choice drug to help lower blood sugar.
        • Most people will have nausea, indigestion, or diarrhea in the first few weeks. You can minimize this if you take it on a full stomach.
        • People with poor kidney function can't use it.
        • Only works if your body can still make your own insulin, a hormone that tells your body what to do with sugar, protein, and fat.
        Tips from our pharmacists for people taking the medication
        InvokanaMetformin
        • Take Invokana (Canagliflozin) before your first meal of the day.
        • Drink plenty of fluids since Invokana (Canagliflozin) can make you thirsty.
        • Eat regular, balanced meals to avoid low blood sugar.
        • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure the medication is working well. Some people may need to test more often.
        • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
        • Always take it with food or switch to the extended release version to avoid upset stomach.
        • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
        • Check your blood sugar regularly.
        Learn more
        More about InvokanaSide effectsReviews & ratingsAlternativesFDA package insert
        More about MetforminSide effectsReviews & ratingsAlternativesFDA package insert