Compare Invokana vs. Onglyza

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Invokana
(canagliflozin)

Onglyza
(saxagliptin)

Lowers blood sugar. Invokana (canagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.Lowers blood sugar. Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.
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Coupons for Invokana
Best available price for 30 (300mg) tablets of invokana
Coupons for Onglyza
Best available price for 30 (5mg) tablets of onglyza
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.52Invokana
Reviews for Invokana
67%
of people (All ages) say Invokana is worth it
56%
say it works well
19%
say it's a big hassle
Have you used Invokana (canagliflozin)?
Worth itNot sureNot worth it

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Have you used Onglyza (saxagliptin)?
Worth itNot sureNot worth it
Side effects
InvokanaOnglyza
  • Yeast infection in women 8%
  • Urinary tract infections 2%
  • Increased urination 4%
  • Yeast infection in men 3%
  • Thirst 3%
  • Vaginal itching 2%
  • Constipation 1%
  • Abdominal pain 1%
More Invokana side effects »
  • Urinary tract infection 1%
  • Headache 1%
  • Swelling in arms and legs 4%
  • Low blood sugar (hypoglycemia) 2%
  • Allergic reactions 2%
More Onglyza side effects »
How it works
InvokanaOnglyza
Invokana (canagliflozin) is an anti-diabetes medication. It lowers blood sugar by causing your body to get rid of sugar in your urine.Onglyza (saxagliptin) is an anti-diabetic drug. It lowers your blood sugar by enhancing your body's release of insulin.
Type of medication
InvokanaOnglyza
Prescription onlyPrescription only
Available as
InvokanaOnglyza
  • Pill
  • Pill
Used for
InvokanaOnglyza
Risk factors for serious side effects
InvokanaOnglyza
  • History of amputations 
  • Peripheral vascular disease (narrowed blood vessels)
  • Nerve problems
  • Diabetic foot ulcers 
  • History of kidney damage
Detailed Invokana (canagliflozin) risks & warnings »
  • Alcoholism
  • Elevated triglycerides
  • History of pancreatitis
  • Gallstones
  • History of heart failure
Detailed Onglyza (saxagliptin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
InvokanaOnglyza
No interactions related info.
  • Certain drugs may interact with Onglyza (saxagliptin), let your doctor know all the medications you are currently taking and before starting Onglyza (saxagliptin).
Alcohol
InvokanaOnglyza
  • Avoid if you are a heavy drinker of alcohol.
No alcohol related info.
Food
InvokanaOnglyza
  • Take once daily before your first meal of the day.
  • You only have to take Invokana (canagliflozin) once a day before meals.
No food related info.
Kidneys and liver
InvokanaOnglyza
  • Not for people with severe kidney problems.
  • May be a good option for those with bad liver function.
Pain
InvokanaOnglyza
  • Rarely, Invokana (canagliflozin) can hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or take certain medicines for blood pressure or anti-inflammatories (NSAIDs). Invokana (canagliflozin) can also lower your blood pressure since it makes you urinate more. Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Invokana (canagliflozin). Make sure to stay hydrated to prevent low blood pressure and kidney problems.
No pain related info.
Weight
InvokanaOnglyza
No weight related info.
  • Does not cause weight gain.
Upsides and benefits
InvokanaOnglyza
  • Lowers A1C (blood sugar) levels by 1%.
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Less likely to cause low blood sugar than other diabetes medicines.
  • Also available as a combination drug with metformin (Invokamet).
  • DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
  • Does not cause weight gain.
  • May be a good option for those with bad liver function.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
Downsides and risks
InvokanaOnglyza
  • You're more likely to have broken bones, yeast infections and urinary tract infections with Invokana (canagliflozin).
  • There's a rare but serious risk of leg and foot amputations with Invokana (canagliflozin). Talk to your doctor if you develop new pain or infections in your feet.
  • Not for people with severe kidney problems.
  • Can raise your cholesterol.
  • Avoid if you are a heavy drinker of alcohol.
  • Typically not first-choice treatment for diabetes.
  • Only lowers A1C (average blood sugar over time) by ~0.5%.
  • Risk for heart failure has not been seen in other medicines that work just like it.
  • May be more expensive than other anti-diabetic medicines.
Tips from our pharmacists for people taking the medication
InvokanaOnglyza
  • Take once daily before your first meal of the day.
  • Invokana (canagliflozin) can cause you to urinate more, so be sure to stay hydrated.
  • Can cause genital yeast infections in females and males.
  • Can cause urinary tract infections (UTI).
  • Can cause low blood sugar, so make sure to check your blood sugar if you don't feel well.
  • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Invokana (canagliflozin).
  • Is taken once daily.
  • Certain drugs may interact with Onglyza (saxagliptin), let your doctor know all the medications you are currently taking and before starting Onglyza (saxagliptin).
  • Stop taking Onglyza (saxagliptin) and see your doctor immediately if you experience severe stomach pain that does not go away, as this may indicate dangerous inflammation of the pancreas.
  • Maintain a consistent diet and exercise regimen to prevent low blood sugar or high blood sugar.
Learn more
More about InvokanaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Invokana (canagliflozin)?
Worth itNot sureNot worth it
More about OnglyzaSide effectsAlternativesFDA package insert
Have you used Onglyza (saxagliptin)?
Worth itNot sureNot worth it