Compare Invokana vs. Onglyza

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Invokana (canagliflozin)

Prescription only

Onglyza (saxagliptin)

Prescription only
Lowers blood sugar.

Invokana (canagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.

5.5/ 7 average rating with 27 reviewsforInvokana
Lowers blood sugar.

Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.

Upsides
  • Lowers A1C (blood sugar) levels by 1%.
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Less likely to cause low blood sugar than other diabetes medicines.
  • Also available as a combination drug with metformin (Invokamet).
  • DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
  • Does not cause weight gain.
  • May be a good option for those with bad liver function.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
Downsides
  • You're more likely to have broken bones, yeast infections and urinary tract infections with Invokana (canagliflozin).
  • There's a rare but serious risk of leg and foot amputations with Invokana (canagliflozin). Talk to your doctor if you develop new pain or infections in your feet.
  • Not for people with severe kidney problems.
  • Can raise your cholesterol.
  • Avoid if you are a heavy drinker of alcohol.
  • Typically not first-choice treatment for diabetes.
  • Only lowers A1C (average blood sugar over time) by ~0.5%.
  • Risk for heart failure has not been seen in other medicines that work just like it.
  • May be more expensive than other anti-diabetic medicines.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$444.76
Find instant savings
Lowest price near you
$402.35
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
27 
67%
think this treatment is worth it
56%
think this treatment works well
19%
think this treatment is a hassle

Have you used Invokana (canagliflozin)?

Leave a review
Not enough review data.Leave a review
Side effects
9possible side effects
  • Yeast infection in women
    11%
  • Urinary tract infections
    6%
  • Increased urination
    5%
  • Yeast infection in men
    4%
  • Thirst
    3%
  • Vaginal itching
    2%
  • Constipation
    2%
  • Nausea
    2%
  • Abdominal pain
    2%
See more detailed side effects
The Onglyza (saxagliptin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Increased risk of leg and foot amputations

    History of amputations 

    ...and 3 more risk factors

  • Kidney damage and low blood pressure

    History of kidney damage

    ...and 3 more risk factors

  • Low blood sugar (hypoglycemia)

    Taking medicines for diabetes

  • Increased acid and ketones in the blood

    Long periods of fasting

    ...and 3 more risk factors

See more detailed risks and warnings
  • inflammation of the pancreas

    Alcoholism

    ...and 3 more risk factors

  • Heart failure

    History of heart failure

    ...and 1 more risk factors

  • Low blood sugar (hypoglycemia)

    Alcohol

    ...and 3 more risk factors

See more detailed risks and warnings