Compare Isordil vs. Digoxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Isordil
(isosorbide dinitrate)

Lanoxin
(digoxin)

Relieves chest pain. Isosorbide dinitrate is good for chest pain, but you have to be able to stick to your dosing schedule or it won't work as well.Improves heart pumping. Digoxin is a good backup for treating heart failure symptoms, but it doesn't, by itself, lower your risk of death.
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Coupons for Isordil
Best available price for 90 (10mg) tablets of isosorbide-dinitrate
Coupons for Digoxin
Best available price for 30 (125mcg) tablets of digoxin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.67Isordil
Reviews for Isordil
46%
of people (All ages) say Isordil is worth it
24%
say it works well
20%
say it's a big hassle
Have you used Isordil (isosorbide dinitrate)?
Worth itNot sureNot worth it
Reviews for Digoxin
64%
-18% worse vs. Isordil
43%
-19% worse vs. Isordil
31%
+11% better vs. Isordil
Have you used Lanoxin (digoxin)?
Worth itNot sureNot worth it
Side effects
IsordilDigoxin

The Isordil FDA package insert doesn’t have numbers about how common side effects are.

More about Isordil side effects »
  • Any side effect 20%
  • Dizziness 1%
  • Mental disturbances 4%
  • Nausea 1%
  • Diarrhea 3%
  • Death 1%
  • Side effects requiring hospitalization 1%
  • Abnormally fast heart beat 2%
  • Vomiting 2%
More Digoxin side effects »
How it works
IsordilDigoxin
Isosorbide dinitrate is a nitrate. It dilates blood vessels all over the body. This makes it less work for the heart to pump, which relieves heart-related chest pain.Digoxin helps your heart work more efficiently. It makes your heart pump slower and stronger, which helps it get more blood and oxygen out to your body and organs.
Type of medication
IsordilDigoxin
Prescription onlyPrescription only
Available as
IsordilDigoxin
  • Pill
  • Extended release
  • Pill
  • Liquid
Used for
IsordilDigoxin
Risk factors for serious side effects
IsordilDigoxin
  • Age 65 years or older
  • Taking drugs for erectile dysfunction
  • Alcohol use
Detailed Isordil (isosorbide dinitrate) risks & warnings »
  • History of heart problems
  • Drug interactions
  • Wolff-Parkinson-White syndrome
  • Low body weight, advanced age, impaired renal function, electrolyte imbalances
  • Overactive or underactive thyroid
Detailed Lanoxin (digoxin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
IsordilDigoxin
No interactions related info.
  • Tell your doctor about other medicines you're taking to avoid drug interactions.
Alcohol
IsordilDigoxin
  • Don't drink alcohol while taking this medicine. It can make you really dizzy.
No alcohol related info.
Upsides and benefits
IsordilDigoxin
  • Treats and prevents heart-related chest pain (angina) from the narrowing of heart blood vessels (coronary artery disease).
  • Used for some abnormal heart rhythms, and for heart failure that can't be controlled by other medications.
  • Relieves shortness of breath, and makes it easier to be active without having symptoms.
  • In studies, Digoxin lowered the risk of having to be admitted to the hospital for worsening heart failure.
Downsides and risks
IsordilDigoxin
  • You can develop tolerance to this medicine over time, which means that the same dose becomes less effective. You have to stick to a really specific dosing schedule to prevent this from happening.
  • Headaches are normal with this medicine and they go away as your body gets used to it, but they can be severe or not tolerable for some people.
  • For heart failure, relieves symptoms, but does not lower the risk of death. That's why it's usually used together with other heart failure medicines that do lower the risk of death.
  • Requires blood tests, especially during the first few weeks of treatment.
Tips from our pharmacists for people taking the medication
IsordilDigoxin
  • Can cause headaches, dizziness, lightheadedness, or fainting.
  • Don't drink alcohol while taking this medicine. It can make you really dizzy.
  • Tell your doctor if you're taking any medicine for erectile dysfunction.
  • Don't stop taking this medicine suddenly.
  • Take it at the same time every day.
  • Drink plenty of water while taking this medicine.
  • Requires routine blood tests to make sure you have the right amount of Digoxin in your body.
  • Tell your doctor about other medicines you're taking to avoid drug interactions.
Learn more
More about IsordilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Isordil (isosorbide dinitrate)?
Worth itNot sureNot worth it
More about DigoxinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lanoxin (digoxin)?
Worth itNot sureNot worth it