Compare Isordil vs. Nitrostat

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Isordil
(Isosorbide Dinitrate)

Nitrostat
(Nitroglycerin)

Relieves chest pain. Isosorbide dinitrate is good for chest pain, but you have to be able to stick to your dosing schedule or it won't work as well.Relieves chest pain. Nitroglycerin is the fastest-working medicine to relieve chest pain, but make sure to sit down before taking it.
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Reviews & ratings
Button Group. All currently active
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3.6739130434782608Isordil
Reviews for Isordil (Isosorbide Dinitrate)
46%
of people say Isordil (Isosorbide Dinitrate) is worth it
24%
say it works well
20%
say it's a big hassle
Reviews for Nitrostat (Nitroglycerin)
40%
6% vs. Isordil (Isosorbide Dinitrate)
50%
+26% vs. Isordil (Isosorbide Dinitrate)
21%
1% vs. Isordil (Isosorbide Dinitrate)
Side effects
IsordilNitrostat

The Isordil FDA package insert doesn’t have numbers about how common side effects are.

More about Isordil side effects »
  • Headache 45%
  • Lightheadedness 2%
More Nitrostat side effects »
How it works
IsordilNitrostat
Isosorbide dinitrate is a nitrate. It dilates blood vessels all over the body. This makes it less work for the heart to pump, which relieves heart-related chest pain.Nitroglycerin is a nitrate. It dilates blood vessels all over the body. This makes it less work for the heart to pump, which relieves heart-related chest pain.
Type of medication
IsordilNitrostat
Vasodilator
Nitrate
Prescription only
Vasodilator
Nitrate
Prescription only
Available as
IsordilNitrostat
  • Pill
  • Extended release
  • Dissolving tablet
  • Pill
  • Extended release
  • Patch
  • Mouth spray
  • Cream, gel, or ointment
  • Rectal gel or ointment
Used for (click to learn more)
IsordilNitrostat
Risk factors for serious side effects
IsordilNitrostat
  • Age 65 years or older
  • Taking drugs for erectile dysfunction
  • Alcohol use
    Detailed Isordil (Isosorbide Dinitrate) risks & warnings »
    • Concurrent use of erectile dysfunction medicine
    • Age 65 years or older
    • Alcohol use
    • Long term use
    Detailed Nitrostat (Nitroglycerin) risks & warnings »
    Pregnancy category
    IsordilNitrostat
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    • Don't drink alcohol while taking this medicine. It can make you really dizzy.
    • Dizziness and falls may occur due to a sudden drop in blood pressure when you change positions, like from lying down or sitting to standing. This is called orthostatic hypotension. If you're sensitive to low blood pressure, change position slowly until your body is used to the medicine. If symptoms continues for more than a week, talk to your doctor. Also tell your doctor if you are taking any drugs for erectile dysfunction, as this can increase the likelihood of dizziness or falls. Drinking alcohol while on this medication may also increase the risk of dizziness or falling.
    • Don't drink alcohol while taking this medicine. It can make dizziness worse.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    IsordilNitrostat
    • Treats and prevents heart-related chest pain (angina) from the narrowing of heart blood vessels (coronary artery disease).
    • First-choice treatment for quick relief of heart-related chest pain (angina).
    • Can also be used to prevent chest pain from happening.
    • Available in various forms that take effect at different speeds and stay in your system for different lengths of time. Sublingual form works the fastest (1-3 minutes) but lasts the shortest in your body (25 minutes), while the patch form takes the longest to start working (30 minutes) but lasts the longest (10-12 hours). Your doctor can help you find the one that's best for you.
    Downsides and risks
    IsordilNitrostat
    • You can develop tolerance to this medicine over time, which means that the same dose becomes less effective. You have to stick to a really specific dosing schedule to prevent this from happening.
    • Headaches are normal with this medicine and they go away as your body gets used to it, but they can be severe or not tolerable for some people.
    • You can develop tolerance to this medicine over time, which means that the same dose becomes less effective. You have to stick to a really specific dosing schedule for the extended-release, ointment, and patch forms to prevent this from happening.
    • Headaches are normal with this medicine and they go away as your body gets used to it, but they can be severe or not tolerable for some people.
    Tips from our pharmacists for people taking the medication
    IsordilNitrostat
    • Can cause headaches, dizziness, lightheadedness, or fainting.
    • Don't drink alcohol while taking this medicine. It can make you really dizzy.
    • Don't stop taking this medicine suddenly.
    • Tell your doctor if you're taking any medicine for erectile dysfunction.
    • Can cause headaches, dizziness, lightheadedness, or fainting. Sit down before taking this medicine in case you get dizzy.
    • Take it exactly as instructed by your doctor.
    • Usually relieves chest pain in 1 to 5 minutes. If pain continues, you can take up to 3 doses, with 5 minutes in between each dose. Call 911 or go to the hospital if you've taken a second dose.
    • Don't drink alcohol while taking this medicine. It can make dizziness worse.
    • Tell your doctor if you're taking any medicine for erectile dysfunction.
    Learn more
    More about IsordilSide effectsReviews & ratingsAlternativesFDA package insert
    More about NitrostatSide effectsReviews & ratingsAlternativesFDA package insert