Compare Isordil vs. Nitrostat

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves chest pain.

Isosorbide dinitrate is good for chest pain, but you have to be able to stick to your dosing schedule or it won't work as well.

2.8/ 5 average rating with 46 reviewsforIsordil
Relieves chest pain.

Nitroglycerin is the fastest-working medicine to relieve chest pain, but make sure to sit down before taking it.

3.5/ 5 average rating with 63 reviewsforNitrostat
Upsides
  • Treats and prevents heart-related chest pain (angina) from the narrowing of heart blood vessels (coronary artery disease).
  • First-choice treatment for quick relief of heart-related chest pain (angina).
  • Can also be used to prevent chest pain from happening.
  • Available in various forms that take effect at different speeds and stay in your system for different lengths of time. Sublingual form works the fastest (1-3 minutes) but lasts the shortest in your body (25 minutes), while the patch form takes the longest to start working (30 minutes) but lasts the longest (10-12 hours). Your doctor can help you find the one that's best for you.
Downsides
  • You can develop tolerance to this medicine over time, which means that the same dose becomes less effective. You have to stick to a really specific dosing schedule to prevent this from happening.
  • Headaches are normal with this medicine and they go away as your body gets used to it, but they can be severe or not tolerable for some people.
  • You can develop tolerance to this medicine over time, which means that the same dose becomes less effective. You have to stick to a really specific dosing schedule for the extended-release, ointment, and patch forms to prevent this from happening.
  • Headaches are normal with this medicine and they go away as your body gets used to it, but they can be severe or not tolerable for some people.
Used for
Dosage forms
  • Pill
  • Extended release
  • Dissolving tablet
  • Pill
  • Extended release
  • Patch
  • Mouth spray
  • Cream, gel, or ointment
  • Rectal gel or ointment
Price
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Reviews
46 reviews so far
46%
saidit'sworth it
24%
saiditworked well
20%
saidit'sa big hassle

Have you used Isordil (Isosorbide Dinitrate)?

Leave a review
63 reviews so far
41%
saidit'sworth it
51%
saiditworked well
21%
saidit'sa big hassle

Have you used Nitrostat (Nitroglycerin)?

Leave a review
Side effects
The Isordil (Isosorbide Dinitrate) FDA package insert doesn’t have numbers about how common side effects are.
4possible side effects
  • Headache
    63%
  • Lightheadedness
    6%
  • Hypotension
    4%
  • Increased Angina
    2%
See more detailed side effects
Risks and risk factors
  • Low blood pressure
    • Age 65 years or older
    • Taking drugs for erectile dysfunction
    • Alcohol use
  • Tolerance
See more detailed risks and warnings
  • Low blood pressure
    • Concurrent use of erectile dysfunction medicine
    • Age 65 years or older
    • Alcohol use
  • Tolerance
    • Long term use
See more detailed risks and warnings