Compare Isordil vs. Nitrostat

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Isordil
(isosorbide dinitrate)

Nitrostat
(nitroglycerin)

Relieves chest pain. Isosorbide dinitrate is good for chest pain, but you have to be able to stick to your dosing schedule or it won't work as well.Relieves chest pain. Nitroglycerin is the fastest-working medicine to relieve chest pain, but make sure to sit down before taking it.
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Coupons for Isordil
Best available price for 90 (10mg) tablets of isosorbide dinitrate
Coupons for Nitrostat
Best available price for 30 (0.2mg) patches of nitroglycerin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.67Isordil
Reviews for Isordil (isosorbide dinitrate)
46%
of people (All ages) say Isordil (isosorbide dinitrate) is worth it
24%
say it works well
20%
say it's a big hassle
Have you used Isordil (isosorbide dinitrate)?
Worth itNot sureNot worth it
Reviews for Nitrostat (nitroglycerin)
41%
-5% worse vs. Isordil (isosorbide dinitrate)
51%
+27% better vs. Isordil (isosorbide dinitrate)
21%
-1% worse vs. Isordil (isosorbide dinitrate)
Have you used Nitrostat (nitroglycerin)?
Worth itNot sureNot worth it
Side effects
IsordilNitrostat

The Isordil FDA package insert doesn’t have numbers about how common side effects are.

More about Isordil side effects »
  • Headache 45%
  • Lightheadedness 2%
  • Low blood pressure 4%
More Nitrostat side effects »
How it works
IsordilNitrostat
Isosorbide dinitrate is a nitrate. It dilates blood vessels all over the body. This makes it less work for the heart to pump, which relieves heart-related chest pain.Nitroglycerin is a nitrate. It dilates blood vessels all over the body. This makes it less work for the heart to pump, which relieves heart-related chest pain.
Type of medication
IsordilNitrostat
Prescription only
Prescription only
Available as
IsordilNitrostat
  • Pill
  • Extended release
  • Dissolving tablet
  • Pill
  • Extended release
  • Patch
  • Mouth spray
  • Cream, gel, or ointment
  • Rectal gel or ointment
Used for
IsordilNitrostat
Risk factors for serious side effects
IsordilNitrostat
  • Age 65 years or older
  • Taking drugs for erectile dysfunction
  • Alcohol use
Detailed Isordil (isosorbide dinitrate) risks & warnings »
  • Concurrent use of erectile dysfunction medicine
  • Age 65 years or older
  • Alcohol use
  • Long term use
Detailed Nitrostat (nitroglycerin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
IsordilNitrostat
  • Don't drink alcohol while taking this medicine. It can make you really dizzy.
  • Don't drink alcohol while taking this medicine. It can make dizziness worse.
Pain
IsordilNitrostat
No pain related info.
  • First-choice treatment for quick relief of heart-related chest pain (angina).
  • Usually relieves chest pain in 1 to 5 minutes. If pain continues, you can take up to 3 doses, with 5 minutes in between each dose. Call 911 or go to the hospital if you've taken a second dose.
Upsides and benefits
IsordilNitrostat
  • Treats and prevents heart-related chest pain (angina) from the narrowing of heart blood vessels (coronary artery disease).
  • First-choice treatment for quick relief of heart-related chest pain (angina).
  • Can also be used to prevent chest pain from happening.
  • Available in various forms that take effect at different speeds and stay in your system for different lengths of time. Sublingual form works the fastest (1-3 minutes) but lasts the shortest in your body (25 minutes), while the patch form takes the longest to start working (30 minutes) but lasts the longest (10-12 hours). Your doctor can help you find the one that's best for you.
Downsides and risks
IsordilNitrostat
  • You can develop tolerance to this medicine over time, which means that the same dose becomes less effective. You have to stick to a really specific dosing schedule to prevent this from happening.
  • Headaches are normal with this medicine and they go away as your body gets used to it, but they can be severe or not tolerable for some people.
  • You can develop tolerance to this medicine over time, which means that the same dose becomes less effective. You have to stick to a really specific dosing schedule for the extended-release, ointment, and patch forms to prevent this from happening.
  • Headaches are normal with this medicine and they go away as your body gets used to it, but they can be severe or not tolerable for some people.
Tips from our pharmacists for people taking the medication
IsordilNitrostat
  • Can cause headaches, dizziness, lightheadedness, or fainting.
  • Don't drink alcohol while taking this medicine. It can make you really dizzy.
  • Tell your doctor if you're taking any medicine for erectile dysfunction.
  • Don't stop taking this medicine suddenly.
  • Can cause headaches, dizziness, lightheadedness, or fainting. Sit down before taking this medicine in case you get dizzy.
  • Take it exactly as instructed by your doctor.
  • Usually relieves chest pain in 1 to 5 minutes. If pain continues, you can take up to 3 doses, with 5 minutes in between each dose. Call 911 or go to the hospital if you've taken a second dose.
  • Don't drink alcohol while taking this medicine. It can make dizziness worse.
  • Tell your doctor if you're taking any medicine for erectile dysfunction.
Learn more
More about IsordilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Isordil (isosorbide dinitrate)?
Worth itNot sureNot worth it
More about NitrostatSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Nitrostat (nitroglycerin)?
Worth itNot sureNot worth it