Compare Itraconazole vs. Diflucan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sporanox
(itraconazole)

Diflucan
(fluconazole)

Treats fungal infections. Sporanox (itraconazole) is effective oral medication that treats many different kinds of fungal infections. However, it has the potential to interact with a lot of other medications and has a few serious but rare side effects.Kills yeast and fungus. Diflucan (Fluconazole) is a quick, cheap, and convenient way to get rid of a yeast infection. (It's used for other kinds of fungal infections, too.) You have to avoid alcohol, though.
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Coupons for Itraconazole
Best available price for 60 (100mg) capsules of itraconazole
Coupons for Diflucan
Best available price for 1 (150mg) tablet of fluconazole
Reviews & ratings
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Have you used Sporanox (itraconazole)?
Worth itNot sureNot worth it
Reviews for Diflucan
73%
-73% worse vs. Itraconazole
60%
-60% worse vs. Itraconazole
20%
+20% better vs. Itraconazole
Have you used Diflucan (fluconazole)?
Worth itNot sureNot worth it
Side effects
ItraconazoleDiflucan
  • Nausea 11%
  • Rash 9%
  • Vomiting 5%
  • Swelling due to fluid retention 4%
  • Headache 4%
  • Itching 3%
  • Fever 3%
  • Diarrhea 3%
  • High blood pressure 3%
  • Tiredness 3%
More Itraconazole side effects »
  • Any side effect 26%
  • Headache 13%
  • Nausea 7%
  • Abdominal pain 6%
  • Diarrhea 3%
  • Skin rash 2%
  • Vomiting 2%
More Diflucan side effects »
How it works
ItraconazoleDiflucan
Sporanox (itraconazole) kills fungus by preventing it from making its protective cell wall.Diflucan (Fluconazole) is an oral antifungal medicine. It prevents yeast and fungi from reproducing and making their protective outer cell wall.
Type of medication
ItraconazoleDiflucan
Prescription onlyPrescription only
Available as
ItraconazoleDiflucan
  • Pill
  • Liquid
  • Pill
  • Liquid
Used for
ItraconazoleDiflucan
Risk factors for serious side effects
ItraconazoleDiflucan
  • History of congestive heart failure
  • Taking other medications that can produce an irregular heartbeat
Detailed Sporanox (itraconazole) risks & warnings »
    Detailed Diflucan (fluconazole) risks & warnings »
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    ItraconazoleDiflucan
    • Sporanox (itraconazole) has many drug interactions and can't be used together with a lot of other medications. Let your doctor or pharmacist know about all of your medications before starting Sporanox (itraconazole).
    • Sporanox (itraconazole) has a lot of drug interactions. Let your doctor or pharmacist know about all of the medications you're taking.
    • Can interact with birth control pills, so you'll need to use condoms or other barriers if you do have sex.
    Alcohol
    ItraconazoleDiflucan
    No alcohol related info.
    • Don't drink alcohol when you take this medication.
    • You have to avoid alcohol while on this medication.
    Kidneys and liver
    ItraconazoleDiflucan
    • Sporanox (itraconazole) can be used by people who have kidney problems.
    No kidneys and liver related info.
    Upsides and benefits
    ItraconazoleDiflucan
    • Sporanox (itraconazole) is effective in treating infections caused by many different types of fungi.
    • Available as a generic in the capsule form.
    • Sporanox (itraconazole) can be used by people who have kidney problems.
    • Available in generic.
    • For women with yeast infections, you only have to take one pill one time.
    Downsides and risks
    ItraconazoleDiflucan
    • The liquid solution is especially likely to cause stomach upset like nausea and diarrhea.
    • Sporanox (itraconazole) is not a good choice for simple fungal infections (like nail infections) in people who have congestive heart failure because it can cause high blood pressure and swelling of the limbs.
    • Sporanox (itraconazole) isn't absorbed in the same way by everyone. You'll likely need to get lab tests done to check on its levels in the blood.
    • Sporanox (itraconazole) can cause serious side effects like allergic reactions, liver toxicity, nerve pain, or hearing loss.
    • Sporanox (itraconazole) has a lot of drug interactions. Let your doctor or pharmacist know about all of the medications you're taking.
    • You have to avoid alcohol while on this medication.
    • You have to avoid having sex for at least a week after you take Fluconazole.
    • Can interact with birth control pills, so you'll need to use condoms or other barriers if you do have sex.
    Tips from our pharmacists for people taking the medication
    ItraconazoleDiflucan
    • If you are taking the pill form, take it after the same meal at the same time each day. If taking the liquid form, take it on an empty stomach with an an accurate measuring device.
    • If you're taking Sporanox (itraconazole) for an infection in the mouth or esophagus, swish the liquid solution in your mouth before swallowing.
    • To make sure that the medicine is effective, be sure to take the full course of this medication, even if you are feeling better.
    • Sporanox (itraconazole) should not be taken with any heartburn medications - especially proton pump inhibitors like Nexium or Prilosec.
    • Be sure to use a reliable form of birth control while taking Sporanox (itraconazole).
    • If you're taking this for a vaginal yeast infection, you only have to take it once. Don't have sex for at least 7 days.
    • For other fungal infections, take it exactly how your doctor tells you to.
    • Don't drink alcohol when you take this medication.
    • If you're on birth control pills, Fluconazole can make them less effective. Consider using another method (condoms, diaphragms) along with the pills.
    • Can cause nausea, vomiting, diarrhea and headache.
    Learn more
    More about ItraconazoleSide effectsAlternativesFDA package insert
    Have you used Sporanox (itraconazole)?
    Worth itNot sureNot worth it
    More about DiflucanSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Diflucan (fluconazole)?
    Worth itNot sureNot worth it