Compare Itraconazole vs. Ketoconazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sporanox
(Itraconazole)

Nizoral
(Ketoconazole)

Coming soon.Treats fungal infections. Nizoral (Ketoconazole) is a medication used on your skin to treat fungal infections; however, it takes several weeks for full recovery, and the directions are specific to each type of medication.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active

Not enough reviews for this drug. Help someone out, leave a review!

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
ItraconazoleKetoconazole

We haven’t found good data for Itraconazole side effects.

FDA side effect reports for Itraconazole »
  • Any side effect 3%
  • Application site reaction 1%
More Ketoconazole side effects »
How it works
ItraconazoleKetoconazole
Coming soon.Nizoral (Ketoconazole) is an antifungal medicine. It prevents yeast and fungi from reproducing and making their protective outer cell wall.
Type of medication
ItraconazoleKetoconazole
Coming soon.
AntifungalPrescription or OTC
Available as
ItraconazoleKetoconazole
  • Pill
  • Liquid
  • Pill
  • Cream, gel, or ointment
  • Foam
  • Shampoo
Used for (click to learn more)
ItraconazoleKetoconazole
  • Aspergillosis
Risk factors for serious side effects
ItraconazoleKetoconazole
Coming soon.
  • Asthma
Detailed Nizoral (Ketoconazole) risks & warnings »
Pregnancy category
ItraconazoleKetoconazole
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
ItraconazoleKetoconazole
Coming soon.
  • Recommended as a first choice medication to treat skin infections caused by fungi, including cradle cap, seborrheic dermatitis, and tinea versicolor.
  • Nizoral (Ketoconazole) isn't taken orally, so it doesn't cause liver issues.
  • Can be used with other medications to help control redness and swelling.
  • The 1% shampoo is available over-the-counter in the drugstore.
Downsides and risks
ItraconazoleKetoconazole
Coming soon.
  • The foams (Extina and Ketodan) and gel (Xolegel) are only available as brand name and can be more expensive.
  • The 2.5% shampoo and creams are available only by prescription, but are generic.
  • The shampoo has to be left on for at least 5-10 minutes after lathering before you rinse it off.
  • It can take a few weeks for the infection to clear and a few months before the skin returns to its normal color.
  • The fungal infections can be confused for other skin infections, so if Nizoral (Ketoconazole) doesn't work, it could be caused by another skin problem.
Tips from our pharmacists for people taking the medication
ItraconazoleKetoconazole
Coming soon.
  • The shampoo is meant to be used once every 3 to 4 days, while the cream, gel and foam are meant to be used one to three times a day.
  • It can take at least 2 to 6 weeks for the infection to completely clear, and it can take 3 to 6 months before the skin returns to its original color for some infections.
  • Make sure Nizoral (Ketoconazole) doesn't get into the eyes.
  • If you're using the foam, spray the foam into the cap, not your hands since it can melt before you put it on, and apply onto the skin, not the hair.
  • Can cause redness, swelling, and an irritated or burning sensation to the area where you put Nizoral (Ketoconazole) on.
Learn more
More about ItraconazoleSide effectsFDA package insert
More about KetoconazoleSide effectsReviews & ratingsAlternativesFDA package insert