Compare Janumet vs. Actos

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Janumet
(Sitagliptin / Metformin)

Actos
(Pioglitazone)

Lowers blood sugar. Janumet is an expensive but very effective combination of oral blood sugar-lowering medicines.Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.53Janumet
Reviews for Janumet (Sitagliptin / Metformin)
46%
of people (All ages) say Janumet (Sitagliptin / Metformin) is worth it
38%
say it works well
15%
say it's a big hassle
Have you used Janumet (Sitagliptin / Metformin)?
Worth itNot sureNot worth it
Reviews for Actos (Pioglitazone)
42%
-4% worse vs. Janumet (Sitagliptin / Metformin)
30%
-8% worse vs. Janumet (Sitagliptin / Metformin)
21%
-6% worse vs. Janumet (Sitagliptin / Metformin)
175 reviews
Have you used Actos (Pioglitazone)?
Worth itNot sureNot worth it
Side effects
JanumetActos
  • Diarrhea 4%
  • Ear, nose, or throat infection 1%
  • Headache 3%
  • Nausea 4%
  • Abdominal pain 1%
  • Vomiting 2%
More Janumet side effects »
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Headache 2%
  • Cardiac failure 2%
  • Back pain 1%
  • Sinus inflammation 1%
  • Muscle pain 2%
More Actos side effects »
How it works
JanumetActos
Janumet is an antidiabetic combination medicine. Metformin lowers the amount of sugar your body produces, and sitagliptin helps your body release more insulin.Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.
Type of medication
JanumetActos
Prescription only
Prescription only
Available as
JanumetActos
  • Pill
  • Extended release
  • Pill
Used for
JanumetActos
Risk factors for serious side effects
JanumetActos
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Contrast dye for procedure
  • Surgery
  • Alcohol use
        Detailed Janumet (Sitagliptin / Metformin) risks & warnings »
        • Heart failure diagnosis
          • Current liver problems
            • Female
            Detailed Actos (Pioglitazone) risks & warnings »
            Pregnancy

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Food
            JanumetActos
            • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
            No food related info.
            Kidneys and liver
            JanumetActos
            • People with poor kidney function can't use it.
            • Janumet (Sitagliptin / Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Janumet (Sitagliptin / Metformin). It may not be a good choice for people with kidney problems. Janumet (Sitagliptin / Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
            No kidneys and liver related info.
            Weight
            JanumetActos
            • Doesn't cause weight gain or low blood sugar.
            • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
            • Can cause weight gain, headache, and fluid retention.
            Upsides and benefits
            JanumetActos
            • 2-in-1 combination medicine. If you need more than one blood sugar medicine, this lowers the number of pills you have to take.
            • Lowers A1c levels by 1-2.5%. (Hemoglobin A1c measures your average blood sugar over time.)
            • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
            • Doesn't cause weight gain or low blood sugar.
            • You don't have to check your blood sugar every day with this medicine.
            • Oral blood sugar-lowering medicine.
            • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
            • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
            • Rarely causes low blood sugar.
            Downsides and risks
            JanumetActos
            • Likely expensive since there's no generic version available.
            • The metformin part of Janumet can cause nausea, indigestion, or diarrhea for most people in the first few weeks.
            • People with poor kidney function can't use it.
            • The sitagliptin part of Janumet can cause some people to have frequent throat infections or nasal congestion.
            • Might raise the risk of problems with your pancreas.
            • May take several weeks to lower blood sugar.
            • You have to check your blood sugar regularly with this medicine.
            • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
            • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
            • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
            • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
            • Slightly raises the risk of bladder cancer.
            Tips from our pharmacists for people taking the medication
            JanumetActos
            • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
            • May cause headaches and cold-like symptoms.
            • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
            • Can be expensive depending on insurance coverage.
            • Check your blood sugar regularly.
            • Takes several weeks to see full effect on blood sugar control.
            • Can cause weight gain, headache, and fluid retention.
            • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
            • Not recommended for patients with certain heart problems.
            • Check your blood sugar regularly.
            Learn more
            More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Janumet (Sitagliptin / Metformin)?
            Worth itNot sureNot worth it
            More about ActosSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Actos (Pioglitazone)?
            Worth itNot sureNot worth it