Compare Janumet vs. Actos

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Janumet
(Sitagliptin / Metformin)

Actos
(Pioglitazone)

Lowers blood sugar. Janumet is an expensive but very effective combination of oral blood sugar-lowering medicines.Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.48051948051948Janumet
Reviews for Janumet (Sitagliptin / Metformin)
44%
of people say Janumet (Sitagliptin / Metformin) is worth it
36%
say it works well
16%
say it's a big hassle
Reviews for Actos (Pioglitazone)
42%
2% vs. Janumet (Sitagliptin / Metformin)
31%
5% vs. Janumet (Sitagliptin / Metformin)
21%
5% vs. Janumet (Sitagliptin / Metformin)
Side effects
JanumetActos
  • Diarrhea 4%
  • Nausea 4%
  • Headache 3%
  • Abdominal pain 1%
  • Ear, nose, or throat infection 1%
More Janumet side effects »
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Sore throat 4%
  • Cardiac failure 2%
  • Muscle pain 2%
  • Headache 2%
  • Back pain 1%
  • Sinus inflammation 1%
More Actos side effects »
How it works
JanumetActos
Janumet is an antidiabetic combination medicine. Metformin lowers the amount of sugar your body produces, and sitagliptin helps your body release more insulin.Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.
Type of medication
JanumetActos
Anti-diabetic
DPP-4 inhibitor
Biguanide
Prescription only
Anti-diabetic
Thiazoladinedione
Prescription only
Available as
JanumetActos
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
JanumetActos
Risk factors for serious side effects
JanumetActos
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Contrast dye for procedure
  • Surgery
  • Alcohol use
        Detailed Janumet (Sitagliptin / Metformin) risks & warnings »
        • Heart failure diagnosis
          • Current liver problems
            • Female
            Detailed Actos (Pioglitazone) risks & warnings »
            Pregnancy category
            JanumetActos
            BFDA pregnancy category (Probably safe)

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            See the FDA package insert
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            Alcohol
            No specific alcohol-related info.No specific alcohol-related info.
            Food
            • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
            No specific food-related info.
            Kidneys and liver
            • People with poor kidney function can't use it.
            • Janumet (Sitagliptin / Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Janumet (Sitagliptin / Metformin). It may not be a good choice for people with kidney problems. Janumet (Sitagliptin / Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
            No specific kidneys and liver-related info.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            No specific sleep-related info.No specific sleep-related info.
            Weight
            • Doesn't cause weight gain or low blood sugar.
            • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
            • Can cause weight gain, headache, and fluid retention.
            • Actos (Pioglitazone) can cause too much fluid buildup in your body, which can cause or worsen congestive heart failure. Your doctor should follow your blood tests and weight closely when you start Actos (Pioglitazone) or increase your dose. People with heart failure classification NYHA Class III/IV shouldn't use Actos (Pioglitazone).
            • Actos (Pioglitazone) may increase fluid buildup in your body, called edema. The risk increases with a higher dose. Tell your doctor about any unexpected weight gain, swelling of extremities, or trouble breathing.
            Upsides and benefits
            JanumetActos
            • 2-in-1 combination medicine. If you need more than one blood sugar medicine, this lowers the number of pills you have to take.
            • Lowers A1c levels by 1-2.5%. (Hemoglobin A1c measures your average blood sugar over time.)
            • Doesn't cause weight gain or low blood sugar.
            • You don't have to check your blood sugar every day with this medicine.
            • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
            • Oral blood sugar-lowering medicine.
            • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
            • Rarely causes low blood sugar.
            • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
            Downsides and risks
            JanumetActos
            • Likely expensive since there's no generic version available.
            • The metformin part of Janumet can cause nausea, indigestion, or diarrhea for most people in the first few weeks.
            • People with poor kidney function can't use it.
            • The sitagliptin part of Janumet can cause some people to have frequent throat infections or nasal congestion.
            • Might raise the risk of problems with your pancreas.
            • May take several weeks to lower blood sugar.
            • You have to check your blood sugar regularly with this medicine.
            • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
            • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
            • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
            • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
            • Slightly raises the risk of bladder cancer.
            Tips from our pharmacists for people taking the medication
            JanumetActos
            • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
            • May cause headaches and cold-like symptoms.
            • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
            • Can be expensive depending on insurance coverage.
            • Check your blood sugar regularly.
            • Takes several weeks to see full effect on blood sugar control.
            • Can cause weight gain, headache, and fluid retention.
            • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
            • Not recommended for patients with certain heart problems.
            • Check your blood sugar regularly.
            Learn more
            More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert
            More about ActosSide effectsReviews & ratingsAlternativesFDA package insert