Compare Janumet vs. Humalog

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Janumet
(sitagliptin / metformin)

Humalog
(insulin lispro)

Lowers your blood sugar. Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only.Lowers blood sugar. Humalog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.53Janumet
Reviews for Janumet
46%
of people (All ages) say Janumet is worth it
38%
say it works well
15%
say it's a big hassle
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it
Reviews for Humalog
64%
-18% worse vs. Janumet
50%
-12% worse vs. Janumet
16%
+1% better vs. Janumet
280 reviews
Have you used Humalog (insulin lispro)?
Worth itNot sureNot worth it
Side effects
JanumetHumalog
  • Low blood sugar 15%
  • Diarrhea 4%
  • Ear, nose, or throat infection 1%
  • Headache 3%
More Janumet side effects »
  • Flu syndrome 35%
  • Sore throat 33%
  • Headache 30%
  • Inflammation inside the nose 25%
  • Pain 20%
  • Cough increased 17%
  • Infection 14%
  • Accidental injury 9%
  • Diarrhea 9%
  • Muscle weakness 7%
More Humalog side effects »
How it works
JanumetHumalog
Janumet (sitagliptin / metformin) is a combination of two anti-diabetic medicines. Metformin lowers the amount of sugar your body produces, and sitagliptin enhances the release of insulin.Humalog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.
Type of medication
JanumetHumalog
Prescription onlyPrescription only
Available as
JanumetHumalog
  • Pill
  • Extended release
  • Injection
Used for
JanumetHumalog
Risk factors for serious side effects
JanumetHumalog
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Janumet (sitagliptin / metformin) risks & warnings »
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
Detailed Humalog (insulin lispro) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
JanumetHumalog
  • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
  • Short-acting insulin good for blood sugar control around meal times.
Kidneys and liver
JanumetHumalog
  • Not appropriate for those with poor kidney function.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Weight
JanumetHumalog
No weight related info.
  • Can cause weight gain and low blood sugar.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
Upsides and benefits
JanumetHumalog
  • This 2-in-1 combination can lower the number of pills you have to take daily.
  • Lowers A1c (average blood sugar over time) up to 2.5%.
  • Available in extended and immediate release forms to allow better control of your blood sugar.
  • Doesn't increase your appetite unlike other anti-diabetic medicines.
  • Does not cause hypoglycemia or very low blood sugar.
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Humalog is a fast-acting insulin that provides sugar control after meals.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Downsides and risks
JanumetHumalog
  • Available as brand name only and may be expensive.
  • Metformin component usually causes upset stomach.
  • Sitagliptin component may increase your risk for throat infections and inflammation of pancreas.
  • Not appropriate for those with poor kidney function.
  • You have to take insulin by injection.
  • You have to check your blood sugar multiple times every day, usually before each meal.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
Tips from our pharmacists for people taking the medication
JanumetHumalog
  • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
  • May cause headaches and cold-like symptoms.
  • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
  • Can be expensive depending on insurance coverage.
  • Check your blood sugar regularly.
  • Short-acting insulin good for blood sugar control around meal times.
  • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
  • Can cause weight gain and low blood sugar.
  • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
  • Always have a good source of sugar nearby for low blood sugar episodes.
  • Make sure you understand how to give yourself the injections.
  • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
  • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
  • Check your blood sugar levels every day.
Learn more
More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it
More about HumalogSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Humalog (insulin lispro)?
Worth itNot sureNot worth it