Compare Janumet vs. Januvia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Janumet
(Sitagliptin / Metformin)

Januvia
(Sitagliptin)

Lowers blood sugar. Janumet is an expensive but very effective combination of oral blood sugar-lowering medicines.Lowers blood sugar. Januvia (Sitagliptin) is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.48051948051948Janumet
Reviews for Janumet (Sitagliptin / Metformin)
44%
of people say Janumet (Sitagliptin / Metformin) is worth it
36%
say it works well
16%
say it's a big hassle
Reviews for Januvia (Sitagliptin)
43%
1% vs. Janumet (Sitagliptin / Metformin)
34%
2% vs. Janumet (Sitagliptin / Metformin)
17%
1% vs. Janumet (Sitagliptin / Metformin)
Side effects
JanumetJanuvia
  • Diarrhea 4%
  • Nausea 4%
  • Headache 3%
  • Abdominal pain 1%
  • Ear, nose, or throat infection 1%
More Janumet side effects »
  • Common cold 2%
  • Diarrhea 1%
More Januvia side effects »
How it works
JanumetJanuvia
Janumet is an antidiabetic combination medicine. Metformin lowers the amount of sugar your body produces, and sitagliptin helps your body release more insulin.Januvia (Sitagliptin) is an anti-diabetic drug. It helps your body release more insulin in order to lower blood sugar.
Type of medication
JanumetJanuvia
Anti-diabetic
DPP-4 inhibitor
Biguanide
Prescription only
Anti-diabetic
DPP-4 inhibitor
Prescription only
Available as
JanumetJanuvia
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
JanumetJanuvia
Risk factors for serious side effects
JanumetJanuvia
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Contrast dye for procedure
  • Surgery
  • Alcohol use
        Detailed Janumet (Sitagliptin / Metformin) risks & warnings »
            Detailed Januvia (Sitagliptin) risks & warnings »
            Pregnancy category
            JanumetJanuvia
            BFDA pregnancy category (Probably safe)

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            See the FDA package insert
            BFDA pregnancy category (Probably safe)

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            See the FDA package insert
            Alcohol
            No specific alcohol-related info.No specific alcohol-related info.
            Food
            • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
            No specific food-related info.
            Kidneys and liver
            • People with poor kidney function can't use it.
            • Janumet (Sitagliptin / Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Janumet (Sitagliptin / Metformin). It may not be a good choice for people with kidney problems. Janumet (Sitagliptin / Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
            No specific kidneys and liver-related info.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            No specific sleep-related info.No specific sleep-related info.
            Weight
            • Doesn't cause weight gain or low blood sugar.
            • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
            Upsides and benefits
            JanumetJanuvia
            • 2-in-1 combination medicine. If you need more than one blood sugar medicine, this lowers the number of pills you have to take.
            • Lowers A1c levels by 1-2.5%. (Hemoglobin A1c measures your average blood sugar over time.)
            • Doesn't cause weight gain or low blood sugar.
            • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
            • You don't have to check your blood sugar every day with this medicine.
            • Oral blood sugar-lowering medicine.
            • Lowers A1c levels by 0.5-0.8%. (Hemoglobin A1c measures your average blood sugar over time.)
            • Uses the hormones naturally produced by your body to affect how sugar is processed.
            • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
            • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
            • You don't have to check your blood sugar every day with this medicine.
            Downsides and risks
            JanumetJanuvia
            • The metformin part of Janumet can cause nausea, indigestion, or diarrhea for most people in the first few weeks.
            • People with poor kidney function can't use it.
            • The sitagliptin part of Janumet can cause some people to have frequent throat infections or nasal congestion.
            • Might raise the risk of problems with your pancreas.
            • Likely expensive since there's no generic version available.
            • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
            • Some people might get frequent throat infections or nasal congestion.
            • Likely expensive since there's no generic version available.
            Tips from our pharmacists for people taking the medication
            JanumetJanuvia
            • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
            • May cause headaches and cold-like symptoms.
            • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
            • Can be expensive depending on insurance coverage.
            • Check your blood sugar regularly.
            • Can cause headache and cold-like symptoms.
            • Tell your doctor about persistent stomach pain, nausea, vomiting, or loss of appetite.
            • Can be expensive depending on insurance coverage.
            • Check your blood sugar regularly.
            Learn more
            More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert
            More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert