Compare Janumet vs. Januvia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Janumet
(sitagliptin / metformin)

Januvia
(sitagliptin)

Lowers your blood sugar. Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only.Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.
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Coupons for Janumet
Best available price for 60 (50mg/1000mg) tablets of janumet
Coupons for Januvia
Best available price for 30 (100mg) tablets of januvia
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.53Janumet
Reviews for Janumet
46%
of people (All ages) say Janumet is worth it
38%
say it works well
15%
say it's a big hassle
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it
Reviews for Januvia
44%
+2% better vs. Janumet
34%
+4% better vs. Janumet
17%
+2% better vs. Janumet
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
Side effects
JanumetJanuvia
  • Low blood sugar 15%
  • Diarrhea 4%
  • Ear, nose, or throat infection 1%
  • Headache 3%
More Janumet side effects »
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
How it works
JanumetJanuvia
Janumet (sitagliptin / metformin) is a combination of two anti-diabetic medicines. Metformin lowers the amount of sugar your body produces, and sitagliptin enhances the release of insulin.Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.
Type of medication
JanumetJanuvia
Prescription onlyPrescription only
Available as
JanumetJanuvia
  • Pill
  • Extended release
  • Pill
Used for
JanumetJanuvia
Risk factors for serious side effects
JanumetJanuvia
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Janumet (sitagliptin / metformin) risks & warnings »
  • History of pancreatitis
  • High blood triglyceride levels
  • Gallstones (stones in gallbladder)
  • History of alchoholism
  • Kidney problems
Detailed Januvia (sitagliptin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
JanumetJanuvia
  • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
  • Take once a day in the morning with or without food.
Kidneys and liver
JanumetJanuvia
  • Not appropriate for those with poor kidney function.
  • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
Pain
JanumetJanuvia
No pain related info.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
Weight
JanumetJanuvia
No weight related info.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
Upsides and benefits
JanumetJanuvia
  • This 2-in-1 combination can lower the number of pills you have to take daily.
  • Lowers A1c (average blood sugar over time) up to 2.5%.
  • Available in extended and immediate release forms to allow better control of your blood sugar.
  • Doesn't increase your appetite unlike other anti-diabetic medicines.
  • Does not cause hypoglycemia or very low blood sugar.
  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
Downsides and risks
JanumetJanuvia
  • Available as brand name only and may be expensive.
  • Metformin component usually causes upset stomach.
  • Sitagliptin component may increase your risk for throat infections and inflammation of pancreas.
  • Not appropriate for those with poor kidney function.
  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
Tips from our pharmacists for people taking the medication
JanumetJanuvia
  • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
  • May cause headaches and cold-like symptoms.
  • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
  • Can be expensive depending on insurance coverage.
  • Check your blood sugar regularly.
  • Take once a day in the morning with or without food.
  • Can cause headache and cold-like symptoms.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
  • Tell your doctor right away if you are experiencing severe joint pain.
  • Check your blood sugar regularly to check for low blood sugar.
Learn more
More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it
More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it