Compare Janumet vs. Levemir

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Janumet
(Sitagliptin / Metformin)

Levemir
(Insulin Detemir)

Lowers blood sugar. Janumet is an expensive but very effective combination of oral blood sugar-lowering medicines.Lowers blood sugar. Levemir is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.48051948051948Janumet
Reviews for Janumet (Sitagliptin / Metformin)
44%
of people say Janumet (Sitagliptin / Metformin) is worth it
36%
say it works well
16%
say it's a big hassle
Reviews for Levemir (Insulin Detemir)
44%
Same vs. Janumet (Sitagliptin / Metformin)
35%
1% vs. Janumet (Sitagliptin / Metformin)
22%
6% vs. Janumet (Sitagliptin / Metformin)
Side effects
JanumetLevemir
  • Diarrhea 4%
  • Nausea 4%
  • Headache 3%
  • Abdominal pain 1%
  • Ear, nose, or throat infection 1%
More Janumet side effects »

The Levemir FDA package insert doesn’t have numbers about how common side effects are.

More about Levemir side effects »
How it works
JanumetLevemir
Janumet is an antidiabetic combination medicine. Metformin lowers the amount of sugar your body produces, and sitagliptin helps your body release more insulin.Levemir is a long-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable throughout the day.
Type of medication
JanumetLevemir
Anti-diabetic
DPP-4 inhibitor
Biguanide
Prescription only
Anti-diabetic
Insulin
Prescription only
Available as
JanumetLevemir
  • Pill
  • Extended release
  • Injection
Used for (click to learn more)
JanumetLevemir
Risk factors for serious side effects
JanumetLevemir
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Contrast dye for procedure
  • Surgery
  • Alcohol use
        Detailed Janumet (Sitagliptin / Metformin) risks & warnings »
        • Insulin dose too high
        • Use of other blood sugar lowering medicines
        • Poor injection techniques
        • Unstable kidney functions
        • Unstable liver functions
        • Use of other medicine that lowers potassium
        • Current electrolyte imbalance
          Detailed Levemir (Insulin Detemir) risks & warnings »
          Pregnancy category
          JanumetLevemir
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
          No specific food-related info.
          Kidneys and liver
          • People with poor kidney function can't use it.
          • Janumet (Sitagliptin / Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Janumet (Sitagliptin / Metformin). It may not be a good choice for people with kidney problems. Janumet (Sitagliptin / Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
          • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          • Doesn't cause weight gain or low blood sugar.
          • Likely to cause moderate weight gain (around 4 to 6 pounds).
          • Can cause weight gain and low blood sugar.
          Upsides and benefits
          JanumetLevemir
          • 2-in-1 combination medicine. If you need more than one blood sugar medicine, this lowers the number of pills you have to take.
          • Lowers A1c levels by 1-2.5%. (Hemoglobin A1c measures your average blood sugar over time.)
          • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
          • Doesn't cause weight gain or low blood sugar.
          • You don't have to check your blood sugar every day with this medicine.
          • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
          • Levemir is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
          • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
          • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
          • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
          Downsides and risks
          JanumetLevemir
          • Likely expensive since there's no generic version available.
          • The metformin part of Janumet can cause nausea, indigestion, or diarrhea for most people in the first few weeks.
          • People with poor kidney function can't use it.
          • The sitagliptin part of Janumet can cause some people to have frequent throat infections or nasal congestion.
          • Might raise the risk of problems with your pancreas.
          • You have to take insulin by injection.
          • You have to check your blood sugar every day.
          • Likely to cause moderate weight gain (around 4 to 6 pounds).
          • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
          Tips from our pharmacists for people taking the medication
          JanumetLevemir
          • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
          • May cause headaches and cold-like symptoms.
          • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
          • Can be expensive depending on insurance coverage.
          • Check your blood sugar regularly.
          • Long-acting insulin good for baseline blood sugar control.
          • Works in 1 hour and lasts about 24 hours.
          • Can cause weight gain and low blood sugar.
          • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
          • Always have a good source of sugar nearby for low blood sugar episodes.
          • Take it at the same time every day.
          • Make sure you understand how to give yourself the injections.
          • Don't shake the vial or mix with another insulin. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
          • Check your blood sugar levels every day.
          Learn more
          More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert
          More about LevemirSide effectsReviews & ratingsAlternativesFDA package insert