Compare Janumet vs. metformin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Janumet
(sitagliptin / metformin)

Glucophage
(metformin)

Lowers blood sugar. Janumet is an expensive but very effective combination of oral blood sugar-lowering medicines.Lowers blood sugar. Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.
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Reviews & ratings
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4.53Janumet
Reviews for Janumet (sitagliptin / metformin)
46%
of people (All ages) say Janumet (sitagliptin / metformin) is worth it
38%
say it works well
15%
say it's a big hassle
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it
Reviews for Glucophage (metformin)
65%
+19% better vs. Janumet (sitagliptin / metformin)
46%
+8% better vs. Janumet (sitagliptin / metformin)
16%
-1% worse vs. Janumet (sitagliptin / metformin)
938 reviews
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it
Side effects
Janumetmetformin
  • Diarrhea 4%
  • Ear, nose, or throat infection 1%
  • Headache 3%
  • Nausea 4%
  • Abdominal pain 1%
  • Vomiting 2%
More Janumet side effects »
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Gas 6%
  • Weakness 3%
  • Indigestion 3%
  • Stomach pain 1%
  • Headache 1%
More metformin side effects »
How it works
Janumetmetformin
Janumet is an antidiabetic combination medicine. Metformin lowers the amount of sugar your body produces, and sitagliptin helps your body release more insulin.Glucophage (metformin) is an anti-diabetic drug. It lowers the amount of sugar your body makes or absorbs, and allows your body use the existing insulin better.
Type of medication
Janumetmetformin
Prescription only
Prescription only
Available as
Janumetmetformin
  • Pill
  • Extended release
  • Pill
  • Extended release pill
  • Liquid
Used for
Janumetmetformin
Risk factors for serious side effects
Janumetmetformin
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Contrast dye for procedure
  • Surgery
  • Alcohol use
        Detailed Janumet (sitagliptin / metformin) risks & warnings »
        • Kidney problems
        • Liver problems
        • Congestive heart failure
        • Using contrast dye for procedures
        • Surgery
        • Alcohol use
          Detailed Glucophage (metformin) risks & warnings »
          Pregnancy

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Alcohol
          Janumetmetformin
          No alcohol related info.
          • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
          • Limit or avoid alcohol when taking this medicine.
          Food
          Janumetmetformin
          • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
          • Always take it with food to lessen stomach upset.
          Kidneys and liver
          Janumetmetformin
          • People with poor kidney function can't use it.
          • Janumet (Sitagliptin / Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Janumet (Sitagliptin / Metformin). It may not be a good choice for people with kidney problems. Janumet (Sitagliptin / Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
          • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
          • Glucophage (metformin) can cause this rare life-threatening condition. Your doctor will check your kidneys and liver before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. You're more likely to get this if you already have kidney problems. Glucophage (metformin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye.
          Weight
          Janumetmetformin
          • Doesn't cause weight gain or low blood sugar.
          • Doesn't cause weight gain.
          Upsides and benefits
          Janumetmetformin
          • 2-in-1 combination medicine. If you need more than one blood sugar medicine, this lowers the number of pills you have to take.
          • Lowers A1c levels by 1-2.5%. (Hemoglobin A1c measures your average blood sugar over time.)
          • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
          • Doesn't cause weight gain or low blood sugar.
          • You don't have to check your blood sugar every day with this medicine.
          • Improves sugar control and lowers A1c levels as much as 2%.
          • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
          • Doesn't cause weight gain.
          • Rarely causes low blood sugar.
          Downsides and risks
          Janumetmetformin
          • Likely expensive since there's no generic version available.
          • The metformin part of Janumet can cause nausea, indigestion, or diarrhea for most people in the first few weeks.
          • People with poor kidney function can't use it.
          • The sitagliptin part of Janumet can cause some people to have frequent throat infections or nasal congestion.
          • Might raise the risk of problems with your pancreas.
          • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
          • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
          • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
          Tips from our pharmacists for people taking the medication
          Janumetmetformin
          • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
          • May cause headaches and cold-like symptoms.
          • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
          • Can be expensive depending on insurance coverage.
          • Check your blood sugar regularly.
          • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
          • Always take it with food to lessen stomach upset.
          • Stay hydrated.
          • Limit or avoid alcohol when taking this medicine.
          • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
          • Check your blood sugar regularly.
          Learn more
          More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Janumet (sitagliptin / metformin)?
          Worth itNot sureNot worth it
          More about metforminSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Glucophage (metformin)?
          Worth itNot sureNot worth it