Compare Januvia vs. Byetta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Januvia
(sitagliptin)

Byetta
(exenatide)

Lowers blood sugar. Januvia (Sitagliptin) is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.Lowers your blood sugar. Byetta (Exenatide) helps lower blood sugar for people with diabetes and causes weight loss, but it has to be given by injection and many people have upset stomach.
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Best available price for 30 (100mg) tablets of sitagliptin
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Reviews & ratings
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4.34Januvia
Reviews for Januvia (sitagliptin)
44%
of people (All ages) say Januvia (sitagliptin) is worth it
34%
say it works well
17%
say it's a big hassle
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
Reviews for Byetta (exenatide)
Not enough review data. Review it!
+6% better vs. Januvia (sitagliptin)
Not enough review data. Review it!
+16% better vs. Januvia (sitagliptin)
Not enough review data. Review it!
+17% better vs. Januvia (sitagliptin)
Have you used Byetta (exenatide)?
Worth itNot sureNot worth it
Side effects
JanuviaByetta
  • Common cold 2%
  • Diarrhea 1%
More Januvia side effects »
  • Low blood sugar 6%
  • Nausea 26%
  • Vomiting 14%
  • Diarrhea 10%
  • Headache 10%
  • Constipation 8%
  • Dizziness 3%
More Byetta side effects »
How it works
JanuviaByetta
Januvia (Sitagliptin) is an anti-diabetic drug. It helps your body release more insulin in order to lower blood sugar.Byetta (Exenatide) is a medication for diabetes. It stimulates your body to produce and release more insulin, lower the sugar hormone (glucagon), and slow down digestion.
Type of medication
JanuviaByetta
Prescription only
Prescription only
Available as
JanuviaByetta
  • Pill
  • Injection
Used for
JanuviaByetta
Risk factors for serious side effects
JanuviaByetta
    Detailed Januvia (sitagliptin) risks & warnings »
    • Severe renal impairment
    • End-stage renal disease
    • Severe gastrointestinal disease
    • Gastroparesis
    Detailed Byetta (exenatide) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    JanuviaByetta
    No interactions related info.
    • Because Byetta (Exenatide) can interact with antibiotics and birth control pills, you can't take it until one hour after these medications.
    Food
    JanuviaByetta
    No food related info.
    • Eat regular, balanced meals to avoid low blood sugar.
    Kidneys and liver
    JanuviaByetta
    No kidneys and liver related info.
    • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
    Pain
    JanuviaByetta
    No pain related info.
    • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medication for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
    Weight
    JanuviaByetta
    • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
    No weight related info.
    Upsides and benefits
    JanuviaByetta
    • Oral blood sugar-lowering medicine.
    • Lowers A1c levels by 0.5-0.8%. (Hemoglobin A1c measures your average blood sugar over time.)
    • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
    • Uses the hormones naturally produced by your body to affect how sugar is processed.
    • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
    • You don't have to check your blood sugar every day with this medicine.
    • Lowers A1c levels by 1% (A1c measures your average blood sugar over time.)
    • Prevents the harmful effects of high sugar levels on your organs.
    • Has a lower chance of causing low blood sugar than medications like glyburide or insulin.
    • Can lower your appetite by making you feel full. Some people also lose weight when taking Byetta (Exenatide).
    • Byetta (Exenatide) is not a replacement for diabetes pills, but you may be able to use it alone without the need for pills.
    • The injectable “pen” has easy to use doses which you may find more convenient than other types of injections.
    Downsides and risks
    JanuviaByetta
    • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
    • Likely expensive since there's no generic version available.
    • Some people might get frequent throat infections or nasal congestion.
    • Only lowers A1c levels by 1%, which may not be enough to get your blood sugar in the safe range.
    • Byetta (Exenatide) must be injected twice a day.
    • Up to 40% of people taking Byetta (Exenatide) have upset stomach and side effects like nausea, vomiting, diarrhea, constipation, or indigestion.
    • Because Byetta (Exenatide) can interact with antibiotics and birth control pills, you can't take it until one hour after these medications.
    • Other diabetes medications work as well and are cheaper.
    Tips from our pharmacists for people taking the medication
    JanuviaByetta
    • Can cause headache and cold-like symptoms.
    • Tell your doctor about persistent stomach pain, nausea, vomiting, or loss of appetite.
    • Can be expensive depending on insurance coverage.
    • Check your blood sugar regularly.
    • Store in the refrigerator until opening. Do not freeze.
    • Give injections in your belly, thighs, or upper arm within an hour of your two main meals of the day (separate doses by 6 or more hours).
    • Change the needle and prime the pen every time you inject.
    • It’s not safe to share this medication with other people, even if you change the needle.
    • Don’t mix with insulin; give separate injections. Can be given at the same time as insulin, but in different injection areas.
    • Eat regular, balanced meals to avoid low blood sugar.
    • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure your medication is working and is safe. Some people may need to test more often, ask your doctor.
    Learn more
    More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Januvia (sitagliptin)?
    Worth itNot sureNot worth it
    More about ByettaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Byetta (exenatide)?
    Worth itNot sureNot worth it