Compare Januvia vs. Glucotrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Januvia
(Sitagliptin)

Glucotrol
(Glipizide)

Lowers blood sugar. Januvia (Sitagliptin) is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.34Januvia
Reviews for Januvia (Sitagliptin)
44%
of people (All ages) say Januvia (Sitagliptin) is worth it
34%
say it works well
17%
say it's a big hassle
143 reviews
Have you used Januvia (Sitagliptin)?
Worth itNot sureNot worth it
Reviews for Glucotrol (Glipizide)
50%
+6% better vs. Januvia (Sitagliptin)
32%
-2% worse vs. Januvia (Sitagliptin)
19%
-2% worse vs. Januvia (Sitagliptin)
332 reviews
Have you used Glucotrol (Glipizide)?
Worth itNot sureNot worth it
Side effects
JanuviaGlucotrol
  • Common cold 2%
  • Diarrhea 1%
More Januvia side effects »
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Drowsiness 2%
More Glucotrol side effects »
How it works
JanuviaGlucotrol
Januvia (Sitagliptin) is an anti-diabetic drug. It helps your body release more insulin in order to lower blood sugar.Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.
Type of medication
JanuviaGlucotrol
Prescription only
Prescription only
Available as
JanuviaGlucotrol
  • Pill
  • Pill
  • Extended release
Used for
JanuviaGlucotrol
Risk factors for serious side effects
JanuviaGlucotrol
      Detailed Januvia (Sitagliptin) risks & warnings »
        • Use of other blood sugar lowering medicines
        • Alcohol
        • Intense physical activity
        • History of sulfa allergies
        Detailed Glucotrol (Glipizide) risks & warnings »
        Pregnancy

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Alcohol
        JanuviaGlucotrol
        No alcohol related info.
        • Avoid drinking alcohol.
        Food
        JanuviaGlucotrol
        No food related info.
        • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
        • Eat regular, balanced meals to avoid low blood sugar.
        Kidneys and liver
        JanuviaGlucotrol
        No kidneys and liver related info.
        • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
        Weight
        JanuviaGlucotrol
        • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
        • Can cause mild weight gain (2 to 3 pounds).
        • Can cause weight gain, dizziness, or stomach upset.
        Upsides and benefits
        JanuviaGlucotrol
        • Oral blood sugar-lowering medicine.
        • Lowers A1c levels by 0.5-0.8%. (Hemoglobin A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        • Uses the hormones naturally produced by your body to affect how sugar is processed.
        • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
        • You don't have to check your blood sugar every day with this medicine.
        • Oral blood sugar-lowering medicine.
        • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
        • One of the least expensive diabetes medicines.
        Downsides and risks
        JanuviaGlucotrol
        • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
        • Likely expensive since there's no generic version available.
        • Some people might get frequent throat infections or nasal congestion.
        • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
        • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
        • Can cause mild weight gain (2 to 3 pounds).
        • Loses effectiveness over time or as your body stops making insulin.
        • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
        Tips from our pharmacists for people taking the medication
        JanuviaGlucotrol
        • Can cause headache and cold-like symptoms.
        • Tell your doctor about persistent stomach pain, nausea, vomiting, or loss of appetite.
        • Can be expensive depending on insurance coverage.
        • Check your blood sugar regularly.
        • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
        • Can cause weight gain, dizziness, or stomach upset.
        • Avoid drinking alcohol.
        • Eat regular, balanced meals to avoid low blood sugar.
        • Check your blood sugar regularly.
        Learn more
        More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Januvia (Sitagliptin)?
        Worth itNot sureNot worth it
        More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Glucotrol (Glipizide)?
        Worth itNot sureNot worth it