Compare Januvia vs. Glucotrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Januvia
(sitagliptin)

Glucotrol
(glipizide)

Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
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Coupons for Januvia
Best available price for 30 (100mg) tablets of sitagliptin
Coupons for Glucotrol
Best available price for 60 (5mg) tablets of glipizide
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.34Januvia
Reviews for Januvia (sitagliptin)
44%
of people (All ages) say Januvia (sitagliptin) is worth it
34%
say it works well
17%
say it's a big hassle
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
Reviews for Glucotrol (glipizide)
50%
+6% better vs. Januvia (sitagliptin)
32%
-2% worse vs. Januvia (sitagliptin)
19%
-2% worse vs. Januvia (sitagliptin)
332 reviews
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
Side effects
JanuviaGlucotrol
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Drowsiness 2%
More Glucotrol side effects »
How it works
JanuviaGlucotrol
Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.
Type of medication
JanuviaGlucotrol
Prescription only
Prescription only
Available as
JanuviaGlucotrol
  • Pill
  • Pill
  • Extended release
Used for
JanuviaGlucotrol
Risk factors for serious side effects
JanuviaGlucotrol
  • History of pancreatitis
  • High blood triglyceride levels
  • Gallstones (stones in gallbladder)
  • History of alchoholism
  • Kidney problems
Detailed Januvia (sitagliptin) risks & warnings »
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
  • History of sulfa allergies
Detailed Glucotrol (glipizide) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
JanuviaGlucotrol
No alcohol related info.
  • Avoid drinking alcohol.
Food
JanuviaGlucotrol
  • Take once a day in the morning with or without food.
  • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
  • Eat regular, balanced meals to avoid low blood sugar.
Kidneys and liver
JanuviaGlucotrol
  • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
  • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
Pain
JanuviaGlucotrol
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
No pain related info.
Weight
JanuviaGlucotrol
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • Can cause mild weight gain (2 to 3 pounds).
  • Can cause weight gain, dizziness, or stomach upset.
Upsides and benefits
JanuviaGlucotrol
  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • Oral blood sugar-lowering medicine.
  • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
  • One of the least expensive diabetes medicines.
Downsides and risks
JanuviaGlucotrol
  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
  • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
  • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
  • Can cause mild weight gain (2 to 3 pounds).
  • Loses effectiveness over time or as your body stops making insulin.
  • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
Tips from our pharmacists for people taking the medication
JanuviaGlucotrol
  • Take once a day in the morning with or without food.
  • Can cause headache and cold-like symptoms.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
  • Tell your doctor right away if you are experiencing severe joint pain.
  • Check your blood sugar regularly to check for low blood sugar.
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Avoid drinking alcohol.
  • Eat regular, balanced meals to avoid low blood sugar.
  • Check your blood sugar regularly.
Learn more
More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it