Compare Januvia vs. Glucotrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Januvia
(sitagliptin)

Glucotrol
(glipizide)

Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.Lowers blood sugar. Glucotrol (glipizide) is an effective medicine for lowering blood sugar, but it can cause your blood sugar level to be too low so you must always carry some form of sugar with you that can be readily used.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.34Januvia
Reviews for Januvia
44%
of people (All ages) say Januvia is worth it
34%
say it works well
17%
say it's a big hassle
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
Reviews for Glucotrol
50%
-6% worse vs. Januvia
32%
+2% better vs. Januvia
19%
+2% better vs. Januvia
332 reviews
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
Side effects
JanuviaGlucotrol
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Low blood sugar 3%
  • Constipation 3%
  • Nausea 3%
  • Headache 2%
More Glucotrol side effects »
How it works
JanuviaGlucotrol
Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.Glucotrol (glipizide) stimulates your body to release insulin and lower blood sugar.
Type of medication
JanuviaGlucotrol
Prescription onlyPrescription only
Available as
JanuviaGlucotrol
  • Pill
  • Pill
  • Extended release pill
Used for
JanuviaGlucotrol
Risk factors for serious side effects
JanuviaGlucotrol
  • History of pancreatitis
  • High blood triglyceride levels
  • Gallstones (stones in gallbladder)
  • History of alchoholism
  • Kidney problems
Detailed Januvia (sitagliptin) risks & warnings »
  • Skipping meals or having inconsistent meal times
  • Drinking alcohol
  • Using other blood sugar-lowering medicine
  • People age 60 or older
  • Those with kidney and/or liver problems
Detailed Glucotrol (glipizide) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
JanuviaGlucotrol
No alcohol related info.
  • Avoid drinking alcohol while taking Glucotrol (glipizide).
Food
JanuviaGlucotrol
  • Take once a day in the morning with or without food.
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
Kidneys and liver
JanuviaGlucotrol
  • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
No kidneys and liver related info.
Pain
JanuviaGlucotrol
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
No pain related info.
Weight
JanuviaGlucotrol
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • Can cause mild weight gain of 2-3lb.
Upsides and benefits
JanuviaGlucotrol
  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • Lowers A1c levels by 1-2%.
  • Glucotrol (glipizide) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Okay to use by people with kidney problems.
  • Available as a generic form and is relatively cheap.
Downsides and risks
JanuviaGlucotrol
  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • While taking Glucotrol (glipizide), your blood sugars should be checked 2 to 5 times a week, but less often once you are on a stable dose.
  • Can cause mild weight gain of 2-3lb.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
Tips from our pharmacists for people taking the medication
JanuviaGlucotrol
  • Take once a day in the morning with or without food.
  • Can cause headache and cold-like symptoms.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
  • Tell your doctor right away if you are experiencing severe joint pain.
  • Check your blood sugar regularly to check for low blood sugar.
  • Take the medicine 30 minutes before eating, usually before your first big meal of the day.
  • Avoid drinking alcohol while taking Glucotrol (glipizide).
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
  • Check your blood sugar regularly.
  • Glucotrol (glipizide) can cause dizziness so avoid activities that require coordination until you know how your body can handle the medicine.
Learn more
More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it