Compare Januvia vs. Glucovance

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Januvia
(Sitagliptin)

Glucovance
(Metformin / Glyburide)

Lowers blood sugar. Januvia (Sitagliptin) is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.Lowers blood sugar. Glucovance (Metformin / Glyburide) is a very effective combo medication to lower blood sugar when taking one medication alone isn't enough. It's likely to cause diarrhea for the first few weeks, and you can’t drink much alcohol.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.340579710144928Januvia
Reviews for Januvia (Sitagliptin)
43%
of people say Januvia (Sitagliptin) is worth it
34%
say it works well
17%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
JanuviaGlucovance
  • Common cold 2%
  • Diarrhea 1%
More Januvia side effects »
  • Low blood sugar 35%
  • Gi side effects 14%
  • Diarrhea 11%
  • Abdominal pain 3%
  • Upper respiratory infection 3%
  • Nausea/vomiting 2%
  • Dizziness 2%
More Glucovance side effects »
How it works
JanuviaGlucovance
Januvia (Sitagliptin) is an anti-diabetic drug. It helps your body release more insulin in order to lower blood sugar.Glucovance (Metformin / Glyburide) is a combination medication for diabetes. Metformin lowers sugar (glucose) production in your body, decreases the amount of glucose getting into your blood, and makes your body more sensitive to insulin. Glyburide helps your body make more insulin to lower blood sugar.
Type of medication
JanuviaGlucovance
Anti-diabetic
DPP-4 inhibitor
Prescription only
Anti-diabetic
Biguanide
Sulfonylurea
Prescription only
Available as
JanuviaGlucovance
  • Pill
  • Pill
Used for (click to learn more)
JanuviaGlucovance
Risk factors for serious side effects
JanuviaGlucovance
      Detailed Januvia (Sitagliptin) risks & warnings »
      • Kidney problems
      • Liver problems
      • Congestive heart failure
      • Using contrast dye for procedures
      • Surgery
      • Alcohol use
        • Elderly
        • Use of other blood sugar lowering medicines
        • Alcohol use
        • Intense physical activity
        • History of sulfa reactions
          Detailed Glucovance (Metformin / Glyburide) risks & warnings »
          Pregnancy category
          JanuviaGlucovance
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.
          • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
          • Try limiting the amount of alcohol you drink while taking this medication.
          Food
          No specific food-related info.
          • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
          Kidneys and liver
          No specific kidneys and liver-related info.
          • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
          • Glucovance (Metformin / Glyburide) can cause lactic acidosis, a rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucovance (Metformin / Glyburide). It may not be a good choice for people with kidney problems. Glucovance (Metformin / Glyburide) should be stopped 48 hours before and/or after surgery or procedure that'll use contrast dye.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
          • Can cause some weight gain.
          Upsides and benefits
          JanuviaGlucovance
          • Oral blood sugar-lowering medicine.
          • Lowers A1c levels by 0.5-0.8%. (Hemoglobin A1c measures your average blood sugar over time.)
          • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
          • Uses the hormones naturally produced by your body to affect how sugar is processed.
          • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
          • You don't have to check your blood sugar every day with this medicine.
          • A combination medication that lowers your blood sugar in multiple ways. It's used by people who need tighter control of their blood sugar.
          • Can greatly lower A1c levels. The Hemoglobin A1c test measures your average blood sugar levels over the last few months.
          • Prevents harmful effects of high blood sugar levels on your organs and blood vessels.
          • Also lowers certain lipid (fat and cholesterol) levels.
          Downsides and risks
          JanuviaGlucovance
          • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
          • Likely expensive since there's no generic version available.
          • Some people might get frequent throat infections or nasal congestion.
          • There's a higher risk of low blood sugar episodes than with other kinds of oral diabetes medications.
          • Most people will have nausea, stomach upset, or diarrhea in the first few weeks. You can lower these symptoms if you take it on a full stomach.
          • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
          • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
          • Can cause some weight gain.
          Tips from our pharmacists for people taking the medication
          JanuviaGlucovance
          • Can cause headache and cold-like symptoms.
          • Tell your doctor about persistent stomach pain, nausea, vomiting, or loss of appetite.
          • Can be expensive depending on insurance coverage.
          • Check your blood sugar regularly.
          • Can cause upset stomach, nausea, and diarrhea in the first couple of weeks.
          • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
          • Tell your doctor about any deep or rapid breathing, persistent nausea, vomiting, or stomach pain.
          • Try limiting the amount of alcohol you drink while taking this medication.
          • Check your blood sugar regularly.
          Learn more
          More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
          More about GlucovanceSide effectsAlternativesFDA package insert