Compare Januvia vs. Glucovance

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Januvia
(sitagliptin)

Glucovance
(metformin / glyburide)

Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.Lowers blood sugar. Glucovance (Metformin / Glyburide) is a very effective combo medication to lower blood sugar when taking one medication alone isn't enough. It's likely to cause diarrhea for the first few weeks, and you can’t drink much alcohol.
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Coupons for Januvia
Best available price for 30 (100mg) tablets of januvia
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.34Januvia
Reviews for Januvia
44%
of people (All ages) say Januvia is worth it
34%
say it works well
17%
say it's a big hassle
143 reviews
Have you used Januvia (sitagliptin)?
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Have you used Glucovance (metformin / glyburide)?
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Side effects
JanuviaGlucovance
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
  • Upper respiratory infection 3%
  • Diarrhea 11%
  • Nausea/vomiting 2%
  • Abdominal pain 3%
  • Dizziness 2%
  • Gi side effects 8%
  • Low blood sugar 8%
More Glucovance side effects »
How it works
JanuviaGlucovance
Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.Glucovance (Metformin / Glyburide) is a combination medication for diabetes. Metformin lowers sugar (glucose) production in your body, decreases the amount of glucose getting into your blood, and makes your body more sensitive to insulin. Glyburide helps your body make more insulin to lower blood sugar.
Type of medication
JanuviaGlucovance
Prescription onlyPrescription only
Available as
JanuviaGlucovance
  • Pill
  • Pill
Used for
JanuviaGlucovance
Risk factors for serious side effects
JanuviaGlucovance
  • History of pancreatitis
  • High blood triglyceride levels
  • Gallstones (stones in gallbladder)
  • History of alchoholism
  • Kidney problems
Detailed Januvia (sitagliptin) risks & warnings »
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Glucovance (metformin / glyburide) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
JanuviaGlucovance
No alcohol related info.
  • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
  • Try limiting the amount of alcohol you drink while taking this medication.
Food
JanuviaGlucovance
  • Take once a day in the morning with or without food.
No food related info.
Kidneys and liver
JanuviaGlucovance
  • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
  • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
  • Glucovance (Metformin / Glyburide) can cause lactic acidosis, a rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucovance (Metformin / Glyburide). It may not be a good choice for people with kidney problems. Glucovance (Metformin / Glyburide) should be stopped 48 hours before and/or after surgery or procedure that'll use contrast dye.
Pain
JanuviaGlucovance
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
No pain related info.
Weight
JanuviaGlucovance
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • Can cause some weight gain.
Upsides and benefits
JanuviaGlucovance
  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • A combination medication that lowers your blood sugar in multiple ways. It's used by people who need tighter control of their blood sugar.
  • Can greatly lower A1c levels. The Hemoglobin A1c test measures your average blood sugar levels over the last few months.
  • Prevents harmful effects of high blood sugar levels on your organs and blood vessels.
  • Also lowers certain lipid (fat and cholesterol) levels.
Downsides and risks
JanuviaGlucovance
  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
  • There's a higher risk of low blood sugar episodes than with other kinds of oral diabetes medications.
  • Most people will have nausea, stomach upset, or diarrhea in the first few weeks. You can lower these symptoms if you take it on a full stomach.
  • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
  • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
  • Can cause some weight gain.
Tips from our pharmacists for people taking the medication
JanuviaGlucovance
  • Take once a day in the morning with or without food.
  • Can cause headache and cold-like symptoms.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
  • Tell your doctor right away if you are experiencing severe joint pain.
  • Check your blood sugar regularly to check for low blood sugar.
  • Can cause upset stomach, nausea, and diarrhea in the first couple of weeks.
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Tell your doctor about any deep or rapid breathing, persistent nausea, vomiting, or stomach pain.
  • Try limiting the amount of alcohol you drink while taking this medication.
  • Check your blood sugar regularly.
Learn more
More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
More about GlucovanceSide effectsAlternativesFDA package insert
Have you used Glucovance (metformin / glyburide)?
Worth itNot sureNot worth it