Compare Januvia vs. Glucovance

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Januvia
(sitagliptin)

glyburide / metformin

Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.Lowers blood sugar. Glyburide / Metformin is an effective combination medicine for lowering blood sugar, but it is likely to cause diarrhea in the first few weeks.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.34Januvia
Reviews for Januvia
44%
of people (All ages) say Januvia is worth it
34%
say it works well
17%
say it's a big hassle
143 reviews
Have you used Januvia (sitagliptin)?
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Have you used Glyburide / Metformin?
Worth itNot sureNot worth it
Side effects
JanuviaGlucovance
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
  • Upper respiratory infection 3%
  • Diarrhea 11%
  • Nausea/vomiting 2%
  • Stomach pain 3%
  • Dizziness 2%
  • Gastrointestinal side effects (diarrhea, nausea/vomiting, and stomach pain) 8%
  • Low blood sugar 8%
More Glucovance side effects »
How it works
JanuviaGlucovance
Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.Glyburide / Metformin combines 2 prescription medicines (glyburide and metformin) into 1 pill to help treat diabetes. Glyburide stimulates your body to release insulin to lower blood sugar. Metformin helps your body use its own insulin more effectively as well as lowers the amount of sugar your body naturally makes and absorbs from food.
Type of medication
JanuviaGlucovance
Prescription onlyPrescription only
Available as
JanuviaGlucovance
  • Pill
  • Pill
Used for
JanuviaGlucovance
Risk factors for serious side effects
JanuviaGlucovance
  • History of pancreatitis
  • High blood triglyceride levels
  • Gallstones (stones in gallbladder)
  • History of alchoholism
  • Kidney problems
Detailed Januvia (sitagliptin) risks & warnings »
  • History of kidney problems
  • History of liver problems
  • Those with congestive heart failure
  • Using contrast dye for procedures
  • Undergoing surgery
Detailed Glyburide / Metformin risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
JanuviaGlucovance
No alcohol related info.
  • Limit the amount of alcohol you drink while taking Glyburide / Metformin.
  • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
Food
JanuviaGlucovance
  • Take once a day in the morning with or without food.
No food related info.
Kidneys and liver
JanuviaGlucovance
  • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
  • Not a good treatment option for those with kidney and/or liver problems.
Pain
JanuviaGlucovance
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
No pain related info.
Weight
JanuviaGlucovance
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • Can cause some weight gain.
Upsides and benefits
JanuviaGlucovance
  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • Glyburide / Metformin effectively lowers blood sugar levels more so than if each of the individual medicines it contains are taken alone.
  • Protects your organs and blood vessels from the harmful effects of high blood sugar levels.
  • Can potentially lower your "bad cholesterol" levels.
  • Glyburide / Metformin is available in a generic form and is cheaper than many other combination diabetes medicines.
Downsides and risks
JanuviaGlucovance
  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • Glyburide / Metformin is likely to cause nausea, stomach upset, or diarrhea in the first few weeks.
  • Not a good treatment option for those with kidney and/or liver problems.
  • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
  • Can cause some weight gain.
Tips from our pharmacists for people taking the medication
JanuviaGlucovance
  • Take once a day in the morning with or without food.
  • Can cause headache and cold-like symptoms.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
  • Tell your doctor right away if you are experiencing severe joint pain.
  • Check your blood sugar regularly to check for low blood sugar.
  • Check your blood sugar regularly.
  • Wear sunscreen and appropriate clothing to protect yourself from the sun.
  • Take the medicine with meals to prevent an upset stomach.
  • Tell your doctor right away if you experience rapid breathing, ongoing nausea, vomiting, or stomach pain.
  • Limit the amount of alcohol you drink while taking Glyburide / Metformin.
Learn more
More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
More about GlucovanceSide effectsAlternativesFDA package insert
Have you used Glyburide / Metformin?
Worth itNot sureNot worth it