Compare Januvia vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Januvia (sitagliptin)

Prescription only

Diabeta (glyburide)

Prescription only
Lowers your blood sugar.

Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.

4.3/ 7 average rating with 143 reviewsforJanuvia
Lowers blood sugar.

Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.

4.4/ 7 average rating with 110 reviewsforglyburide
Upsides
  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
Downsides
  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$415.3
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$10
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Reviews
143 
44%
think this treatment is worth it
34%
think this treatment works well
17%
think this treatment is a hassle

Have you used Januvia (sitagliptin)?

Leave a review
110 
45%
think this treatment is worth it
34%
think this treatment works well
21%
think this treatment is a hassle

Have you used Diabeta (glyburide)?

Leave a review
Side effects
3possible side effects
  • Common cold
    5%
  • Diarrhea
    3%
  • Abdominal pain
    2%
See more detailed side effects
The Diabeta (glyburide) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Death from inflammation of the pancreas (pancreatitis)

    History of pancreatitis

    ...and 4 more risk factors

  • Kidney damage

    Pre-existing kidney damage

  • Low blood sugar (hypoglycemia)

    Taking medicines for diabetes

See more detailed risks and warnings
  • Low blood sugar

    Over age 65

    ...and 4 more risk factors

  • Severe allergic reactions

    History of sulfa allergies

See more detailed risks and warnings