Compare Januvia vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Januvia
(sitagliptin)

Diabeta
(glyburide)

Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.34Januvia
Reviews for Januvia
44%
of people (All ages) say Januvia is worth it
34%
say it works well
17%
say it's a big hassle
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
Reviews for glyburide
45%
-1% worse vs. Januvia
34%
Same vs. Januvia
21%
+4% better vs. Januvia
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Side effects
Januviaglyburide
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
How it works
Januviaglyburide
Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.
Type of medication
Januviaglyburide
Prescription onlyPrescription only
Available as
Januviaglyburide
  • Pill
  • Pill
Used for
Januviaglyburide
Risk factors for serious side effects
Januviaglyburide
  • History of pancreatitis
  • High blood triglyceride levels
  • Gallstones (stones in gallbladder)
  • History of alchoholism
  • Kidney problems
Detailed Januvia (sitagliptin) risks & warnings »
  • Over age 65
  • Kidney problems
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
Detailed Diabeta (glyburide) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
Januviaglyburide
No alcohol related info.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
Food
Januviaglyburide
  • Take once a day in the morning with or without food.
  • Eat well-balanced meals to avoid low blood sugar.
Kidneys and liver
Januviaglyburide
  • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
  • Not ideal for elderly or those with poor kidney function.
Pain
Januviaglyburide
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
No pain related info.
Weight
Januviaglyburide
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • Can cause weight gain, dizziness, or stomach upset.
  • Can cause weight gain (about 2 to 3 pounds).
Upsides and benefits
Januviaglyburide
  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
Downsides and risks
Januviaglyburide
  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
Tips from our pharmacists for people taking the medication
Januviaglyburide
  • Take once a day in the morning with or without food.
  • Can cause headache and cold-like symptoms.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
  • Tell your doctor right away if you are experiencing severe joint pain.
  • Check your blood sugar regularly to check for low blood sugar.
  • Check your blood sugar regularly.
  • Eat well-balanced meals to avoid low blood sugar.
  • Works best if you take it 30 minutes before first main meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
Learn more
More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
More about glyburideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it