Compare Januvia vs. Human Insulin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Januvia (sitagliptin)

Prescription only

Humulin (Human Insulin)

Prescription only
Lowers your blood sugar.

Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.

4.3/ 7 average rating with 143 reviewsforJanuvia
Lowers blood sugar.

This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.

5.0/ 7 average rating with 57 reviewsforHuman Insulin
Upsides
  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • Some types of this medication are available without a prescription.
  • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
  • Available in different combinations so that you can do one shot or multiple shots a day.
Downsides
  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
  • Has to be taken exactly as directed or it can cause high or low blood sugar.
  • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
Used for
Dosage forms
  • Pill
  • Injection
  • Inhaler
Price
Lowest price near you
$415.3
Find instant savings
No pricing information available
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
143 
44%
think this treatment is worth it
34%
think this treatment works well
17%
think this treatment is a hassle

Have you used Januvia (sitagliptin)?

Leave a review
57 
67%
think this treatment is worth it
46%
think this treatment works well
11%
think this treatment is a hassle

Have you used Humulin (Human Insulin)?

Leave a review
Side effects
3possible side effects
  • Common cold
    5%
  • Diarrhea
    3%
  • Abdominal pain
    2%
See more detailed side effects
The Humulin (Human Insulin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Death from inflammation of the pancreas (pancreatitis)

    History of pancreatitis

    ...and 4 more risk factors

  • Kidney damage

    Pre-existing kidney damage

  • Low blood sugar (hypoglycemia)

    Taking medicines for diabetes

See more detailed risks and warnings