Compare Januvia vs. Human insulin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Januvia
(Sitagliptin)

Humulin
(Human Insulin)

Lowers blood sugar. Januvia (Sitagliptin) is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.Lowers blood sugar. This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.340579710144928Januvia
Reviews for Januvia (Sitagliptin)
43%
of people say Januvia (Sitagliptin) is worth it
34%
say it works well
17%
say it's a big hassle
Reviews for Humulin (Human Insulin)
67%
+24% vs. Januvia (Sitagliptin)
46%
+12% vs. Januvia (Sitagliptin)
11%
+6% vs. Januvia (Sitagliptin)
Side effects
JanuviaHuman insulin
  • Common cold 2%
  • Diarrhea 1%
More Januvia side effects »

The Human insulin FDA package insert doesn’t have numbers about how common side effects are.

More about Human insulin side effects »
How it works
JanuviaHuman insulin
Januvia (Sitagliptin) is an anti-diabetic drug. It helps your body release more insulin in order to lower blood sugar.Insulin is a hormone normally produced by your pancreas. It helps your body absorb and store sugar and fat from your bloodstream.
Type of medication
JanuviaHuman insulin
Anti-diabetic
DPP-4 inhibitor
Prescription only
Anti-diabetic
Insulin
Prescription only
Available as
JanuviaHuman insulin
  • Pill
  • Injection
  • Inhaler
Used for (click to learn more)
JanuviaHuman insulin
Risk factors for serious side effects
JanuviaHuman insulin
      Detailed Januvia (Sitagliptin) risks & warnings »
            Detailed Humulin (Human Insulin) risks & warnings »
            Pregnancy category
            JanuviaHuman insulin
            BFDA pregnancy category (Probably safe)

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            See the FDA package insert
            BFDA pregnancy category (Probably safe)

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            See the FDA package insert
            Alcohol
            No specific alcohol-related info.No specific alcohol-related info.
            Food
            No specific food-related info.No specific food-related info.
            Kidneys and liver
            No specific kidneys and liver-related info.No specific kidneys and liver-related info.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            No specific sleep-related info.No specific sleep-related info.
            Weight
            • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
            • People on Humulin (Human Insulin) can experience weight gain. Talk to your doctor or dietitian about changing your diet if this bothers you.
            Upsides and benefits
            JanuviaHuman insulin
            • Oral blood sugar-lowering medicine.
            • Lowers A1c levels by 0.5-0.8%. (Hemoglobin A1c measures your average blood sugar over time.)
            • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
            • Uses the hormones naturally produced by your body to affect how sugar is processed.
            • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
            • You don't have to check your blood sugar every day with this medicine.
            • Some types of this medication are available without a prescription.
            • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
            • Available in different combinations so that you can do one shot or multiple shots a day.
            Downsides and risks
            JanuviaHuman insulin
            • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
            • Likely expensive since there's no generic version available.
            • Some people might get frequent throat infections or nasal congestion.
            • Has to be taken exactly as directed or it can cause high or low blood sugar.
            • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
            Tips from our pharmacists for people taking the medication
            JanuviaHuman insulin
            • Can cause headache and cold-like symptoms.
            • Tell your doctor about persistent stomach pain, nausea, vomiting, or loss of appetite.
            • Can be expensive depending on insurance coverage.
            • Check your blood sugar regularly.
            • Change the location where you give yourself the shot every time.
            • Don't use if the liquid in the vial looks different than normal.
            • Store the unopened vials in the refrigerator. The used vials can be kept at room temperature for up to 28 days.
            • Take the medication exactly how your doctor tells you to.
            • Know the symptoms of low blood sugar.
            Learn more
            More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
            More about Human insulinSide effectsReviews & ratingsAlternativesFDA package insert