Compare Januvia vs. Janumet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Januvia
(sitagliptin)

Janumet
(sitagliptin / metformin)

Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.Lowers your blood sugar. Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only.
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Best available price for 30 (100mg) tablets of sitagliptin
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.34Januvia
Reviews for Januvia (sitagliptin)
44%
of people (All ages) say Januvia (sitagliptin) is worth it
34%
say it works well
17%
say it's a big hassle
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
Reviews for Janumet (sitagliptin / metformin)
46%
+2% better vs. Januvia (sitagliptin)
38%
+4% better vs. Januvia (sitagliptin)
15%
+2% better vs. Januvia (sitagliptin)
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it
Side effects
JanuviaJanumet
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
  • Low blood sugar 15%
  • Diarrhea 4%
  • Ear, nose, or throat infection 1%
  • Headache 3%
More Janumet side effects »
How it works
JanuviaJanumet
Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.Janumet (sitagliptin / metformin) is a combination of two anti-diabetic medicines. Metformin lowers the amount of sugar your body produces, and sitagliptin enhances the release of insulin.
Type of medication
JanuviaJanumet
Prescription only
Prescription only
Available as
JanuviaJanumet
  • Pill
  • Pill
  • Extended release
Used for
JanuviaJanumet
Risk factors for serious side effects
JanuviaJanumet
  • History of pancreatitis
  • High blood triglyceride levels
  • Gallstones (stones in gallbladder)
  • History of alchoholism
  • Kidney problems
Detailed Januvia (sitagliptin) risks & warnings »
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Janumet (sitagliptin / metformin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
JanuviaJanumet
  • Take once a day in the morning with or without food.
  • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
Kidneys and liver
JanuviaJanumet
  • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
  • Not appropriate for those with poor kidney function.
Pain
JanuviaJanumet
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
No pain related info.
Weight
JanuviaJanumet
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
No weight related info.
Upsides and benefits
JanuviaJanumet
  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • This 2-in-1 combination can lower the number of pills you have to take daily.
  • Lowers A1c (average blood sugar over time) up to 2.5%.
  • Available in extended and immediate release forms to allow better control of your blood sugar.
  • Doesn't increase your appetite unlike other anti-diabetic medicines.
  • Does not cause hypoglycemia or very low blood sugar.
Downsides and risks
JanuviaJanumet
  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
  • Available as brand name only and may be expensive.
  • Metformin component usually causes upset stomach.
  • Sitagliptin component may increase your risk for throat infections and inflammation of pancreas.
  • Not appropriate for those with poor kidney function.
Tips from our pharmacists for people taking the medication
JanuviaJanumet
  • Take once a day in the morning with or without food.
  • Can cause headache and cold-like symptoms.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
  • Tell your doctor right away if you are experiencing severe joint pain.
  • Check your blood sugar regularly to check for low blood sugar.
  • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
  • May cause headaches and cold-like symptoms.
  • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
  • Can be expensive depending on insurance coverage.
  • Check your blood sugar regularly.
Learn more
More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it