Compare Januvia vs. Lantus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Januvia
(Sitagliptin)

Lantus
(Insulin Glargine)

Lowers blood sugar. Januvia (Sitagliptin) is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.Lowers blood sugar. Lantus (Insulin Glargine) is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.340579710144928Januvia
Reviews for Januvia (Sitagliptin)
43%
of people say Januvia (Sitagliptin) is worth it
34%
say it works well
17%
say it's a big hassle
Reviews for Lantus (Insulin Glargine)
67%
+24% vs. Januvia (Sitagliptin)
51%
+17% vs. Januvia (Sitagliptin)
14%
+3% vs. Januvia (Sitagliptin)
Side effects
JanuviaLantus
  • Common cold 2%
  • Diarrhea 1%
More Januvia side effects »

The Lantus FDA package insert doesn’t have numbers about how common side effects are.

More about Lantus side effects »
How it works
JanuviaLantus
Januvia (Sitagliptin) is an anti-diabetic drug. It helps your body release more insulin in order to lower blood sugar.Lantus (Insulin Glargine) is a long-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable throughout the day.
Type of medication
JanuviaLantus
Anti-diabetic
DPP-4 inhibitor
Prescription only
Anti-diabetic
Insulin
Prescription only
Available as
JanuviaLantus
  • Pill
  • Injection
Used for (click to learn more)
JanuviaLantus
Risk factors for serious side effects
JanuviaLantus
      Detailed Januvia (Sitagliptin) risks & warnings »
      • Insulin dose too high
      • Use of other blood sugar lowering medicines
      • Poor injection techniques
      • Unstable kidney functions
      • Unstable liver functions
      • Use of other medicine that lowers potassium
      • Current electrolyte imbalance
        Detailed Lantus (Insulin Glargine) risks & warnings »
        Pregnancy category
        JanuviaLantus
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.
        • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
        • Likely to cause moderate weight gain (around 4 to 6 pounds).
        • Can cause weight gain and low blood sugar.
        Upsides and benefits
        JanuviaLantus
        • Oral blood sugar-lowering medicine.
        • Lowers A1c levels by 0.5-0.8%. (Hemoglobin A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        • Uses the hormones naturally produced by your body to affect how sugar is processed.
        • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
        • You don't have to check your blood sugar every day with this medicine.
        • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
        • Lantus is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
        • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
        • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
        • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
        Downsides and risks
        JanuviaLantus
        • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
        • Likely expensive since there's no generic version available.
        • Some people might get frequent throat infections or nasal congestion.
        • You have to take insulin by injection.
        • You have to check your blood sugar every day.
        • Likely to cause moderate weight gain (around 4 to 6 pounds).
        • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
        Tips from our pharmacists for people taking the medication
        JanuviaLantus
        • Can cause headache and cold-like symptoms.
        • Tell your doctor about persistent stomach pain, nausea, vomiting, or loss of appetite.
        • Can be expensive depending on insurance coverage.
        • Check your blood sugar regularly.
        • Long-acting insulin good for baseline blood sugar control.
        • Works in 1 hour and lasts about 24 hours.
        • Can cause weight gain and low blood sugar.
        • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
        • Always have a good source of sugar nearby for low blood sugar episodes.
        • Take it at the same time every day.
        • Make sure you understand how to give yourself the injections.
        • Don't shake the vial or mix with another insulin. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
        • Check your blood sugar levels every day.
        Learn more
        More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
        More about LantusSide effectsReviews & ratingsAlternativesFDA package insert