Compare Januvia vs. Lantus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Januvia
(sitagliptin)

Lantus
(insulin glargine)

Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.Lowers blood sugar. Lantus (Insulin Glargine) is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
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Coupons for Januvia
Best available price for 30 (100mg) tablets of januvia
Coupons for Lantus
Best available price for 1 (5 solostar pens of 3ml) carton of lantus
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.34Januvia
Reviews for Januvia
44%
of people (All ages) say Januvia is worth it
34%
say it works well
17%
say it's a big hassle
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
Reviews for Lantus
67%
-23% worse vs. Januvia
51%
-17% worse vs. Januvia
14%
-3% worse vs. Januvia
584 reviews
Have you used Lantus (insulin glargine)?
Worth itNot sureNot worth it
Side effects
JanuviaLantus
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
  • Ear, nose, or throat infection 22%
  • Infection 9%
  • Accidental injury 6%
  • Headache 6%
  • Ankle and leg swelling 20%
  • High blood pressure 20%
  • Sinus inflammation 19%
  • Flu 19%
  • Clouded eye lens 18%
  • Bronchitis 15%
More Lantus side effects »
How it works
JanuviaLantus
Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.Lantus (Insulin Glargine) is a long-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable throughout the day.
Type of medication
JanuviaLantus
Prescription onlyPrescription only
Available as
JanuviaLantus
  • Pill
  • Injection
Used for
JanuviaLantus
Risk factors for serious side effects
JanuviaLantus
  • History of pancreatitis
  • High blood triglyceride levels
  • Gallstones (stones in gallbladder)
  • History of alchoholism
  • Kidney problems
Detailed Januvia (sitagliptin) risks & warnings »
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
Detailed Lantus (insulin glargine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
JanuviaLantus
  • Take once a day in the morning with or without food.
No food related info.
Kidneys and liver
JanuviaLantus
  • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Pain
JanuviaLantus
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
No pain related info.
Weight
JanuviaLantus
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Can cause weight gain and low blood sugar.
Upsides and benefits
JanuviaLantus
  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Lantus is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Downsides and risks
JanuviaLantus
  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
  • You have to take insulin by injection.
  • You have to check your blood sugar every day.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
Tips from our pharmacists for people taking the medication
JanuviaLantus
  • Take once a day in the morning with or without food.
  • Can cause headache and cold-like symptoms.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
  • Tell your doctor right away if you are experiencing severe joint pain.
  • Check your blood sugar regularly to check for low blood sugar.
  • Long-acting insulin good for baseline blood sugar control.
  • Works in 1 hour and lasts about 24 hours.
  • Can cause weight gain and low blood sugar.
  • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
  • Always have a good source of sugar nearby for low blood sugar episodes.
  • Take it at the same time every day.
  • Make sure you understand how to give yourself the injections.
  • Don't shake the vial or mix with another insulin. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
  • Check your blood sugar levels every day.
Learn more
More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
More about LantusSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lantus (insulin glargine)?
Worth itNot sureNot worth it