Compare Januvia vs. Victoza

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Januvia
(sitagliptin)

Victoza
(liraglutide)

Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.Lowers your blood sugar. Victoza (liraglutide) is a medicine you inject once a day to control diabetes, but it can be expensive.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.34Januvia
Reviews for Januvia
44%
of people (All ages) say Januvia is worth it
34%
say it works well
17%
say it's a big hassle
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
Reviews for Victoza
73%
-29% worse vs. Januvia
91%
-57% worse vs. Januvia
27%
+10% better vs. Januvia
Have you used Victoza (liraglutide)?
Worth itNot sureNot worth it
Side effects
JanuviaVictoza
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
  • Nausea 13%
  • Headache 4%
  • Diarrhea 6%
  • Low appetite 9%
  • Runny nose and congestion 1%
  • Head cold 1%
  • Vomiting 4%
  • Constipation 4%
  • Indigestion 3%
  • Back pain 1%
More Victoza side effects »
How it works
JanuviaVictoza
Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.Victoza (liraglutide) is a medication for diabetes. It stimulates your body to make and release more insulin, stops the body from releasing more sugar, and slows down digestion.
Type of medication
JanuviaVictoza
Prescription onlyPrescription only
Available as
JanuviaVictoza
  • Pill
  • Injection
Used for
JanuviaVictoza
Risk factors for serious side effects
JanuviaVictoza
  • History of pancreatitis
  • High blood triglyceride levels
  • Gallstones (stones in gallbladder)
  • History of alchoholism
  • Kidney problems
Detailed Januvia (sitagliptin) risks & warnings »
  • History of MTC
  • History of MEN 2
  • History of pancreatitis
  • History of gallstones
  • alcoholism
Detailed Victoza (liraglutide) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
JanuviaVictoza
  • Take once a day in the morning with or without food.
No food related info.
Kidneys and liver
JanuviaVictoza
  • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
  • Victoza (liraglutide) can cause or worsen kidney damage. This is more likely to happen if you've had nausea or vomiting, diarrhea or dehydration. Make sure to drink plenty of fluids and stay hydrated when you're sick. If you have kidney damage already, your doctor might do regular lab tests while you're taking Victoza (liraglutide) to make sure your kidneys stay healthy.
  • No limitation for people with kidney problems, but close monitoring is recommended.
Pain
JanuviaVictoza
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
No pain related info.
Weight
JanuviaVictoza
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • Helps with weight loss and controls appetite.
Upsides and benefits
JanuviaVictoza
  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • Lowers A1c (average blood sugar over time) up to 1.5%.
  • Helps with weight loss and controls appetite.
  • Only medicine in this class with proven heart health benefits.
  • No limitation for people with kidney problems, but close monitoring is recommended.
  • Medicine is ready to use, without need to mix.
Downsides and risks
JanuviaVictoza
  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
  • Only available as an injection.
  • Brand name medicine and can be expensive.
  • Compared to other similar medicines, you have to inject this every day.
Tips from our pharmacists for people taking the medication
JanuviaVictoza
  • Take once a day in the morning with or without food.
  • Can cause headache and cold-like symptoms.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
  • Tell your doctor right away if you are experiencing severe joint pain.
  • Check your blood sugar regularly to check for low blood sugar.
  • Inject the dose given by your doctor daily at the same time on your belly, thighs, or the back of your upper arm. To be used with or without food.
  • You may have low appetite, nausea, vomiting, diarrhea, or stomach pain, which may get better with time.
  • Let your doctor know if you have severe and/or persistent stomach pain or nausea with or without vomiting.
  • Unused pens should be stored in the refrigerator, but the pen in use can be kept at room temperature for up to 30 days.
Learn more
More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
More about VictozaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Victoza (liraglutide)?
Worth itNot sureNot worth it