Compare Jardiance vs. Actos

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Jardiance
(empagliflozin)

Actos
(pioglitazone)

Lowers blood sugar. Jardiance (empagliflozin) lowers blood sugar for people with diabetes, but can increase the chance of a yeast infection.Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Actos
Best available price for 30 (30mg) tablets of actos
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Jardiance (empagliflozin)?
Worth itNot sureNot worth it
Reviews for Actos
42%
-42% worse vs. Jardiance
30%
-30% worse vs. Jardiance
21%
+21% better vs. Jardiance
175 reviews
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it
Side effects
JardianceActos
  • Low blood sugar 3%
  • Urinary tract infection 1%
  • Yeast infection in women 3%
  • Elevated cholesterol levels 1%
  • Increased urination 2%
  • Yeast infection in men 3%
  • Nausea 1%
More Jardiance side effects »
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Headache 2%
  • Cardiac failure 2%
  • Back pain 1%
  • Sinus inflammation 1%
  • Muscle pain 2%
More Actos side effects »
How it works
JardianceActos
Jardiance (empagliflozin) is an anti-diabetes medication. It passes the sugar from your blood through your urine.Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.
Type of medication
JardianceActos
Prescription onlyPrescription only
Available as
JardianceActos
  • Pill
  • Pill
Used for
JardianceActos
Risk factors for serious side effects
JardianceActos
  • Over age 65
  • Kidney disease
  • Taking blood pressure medications
  • Dehydration
  • Poor baseline kidney function
Detailed Jardiance (empagliflozin) risks & warnings »
  • Heart failure diagnosis
  • Current liver problems
  • Female
Detailed Actos (pioglitazone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
JardianceActos
  • Take once a day in the morning with or without food.
No food related info.
Kidneys and liver
JardianceActos
  • Jardiance (empagliflozin) can cause or worsen kidney problems. Make sure to stay properly hydrated. Get blood test for kidney function before starting Jardiance (empagliflozin), a few weeks after starting, and regularly thereafter.
No kidneys and liver related info.
Pain
JardianceActos
  • Let your doctor know of any constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting.
No pain related info.
Weight
JardianceActos
  • Can cause weight loss.
  • Can cause weight gain, headache, and fluid retention.
  • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
Upsides and benefits
JardianceActos
  • Lowers A1c (average blood sugar over time) levels up to 1%.
  • Can prevent death from heart attack, stroke, or heart failure if you have pre-existing heart disease.
  • Can be easily taken orally as a pill.
  • Can cause weight loss.
  • Not likely to cause hypoglycemia or very low blood sugar.
  • Oral blood sugar-lowering medicine.
  • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • Rarely causes low blood sugar.
Downsides and risks
JardianceActos
  • More expensive since it's available as brand name only.
  • Can cause dehydration.
  • May take several weeks to lower blood sugar.
  • You have to check your blood sugar regularly with this medicine.
  • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
  • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
  • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
  • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
  • Slightly raises the risk of bladder cancer.
Tips from our pharmacists for people taking the medication
JardianceActos
  • Take once a day in the morning with or without food.
  • You urinate more often so make sure to stay properly hydrated.
  • Can lower blood pressure.
  • Increases the chances of yeast or urinary tract infection, so practice good hygiene.
  • Check blood sugar and blood pressure regularly.
  • Let your doctor know of any constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting.
  • Takes several weeks to see full effect on blood sugar control.
  • Can cause weight gain, headache, and fluid retention.
  • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
  • Not recommended for patients with certain heart problems.
  • Check your blood sugar regularly.
Learn more
More about JardianceSide effectsAlternativesFDA package insert
Have you used Jardiance (empagliflozin)?
Worth itNot sureNot worth it
More about ActosSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it