Compare Jardiance vs. Glucotrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Jardiance
(empagliflozin)

Glucotrol XL
(glipizide)

Lowers blood sugar. Jardiance (empagliflozin) lowers blood sugar for people with diabetes, but can increase the chance of a yeast infection.Lowers blood sugar. Glucotrol XL (glipizide) is an effective medicine for lowering blood sugar, but it can cause your blood sugar level to be too low, so you must always carry some form of sugar with you that can be readily used.
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Coupons for Glucotrol
Best available price for 60 (5mg) tablets of glucotrol
Reviews & ratings
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Have you used Jardiance (empagliflozin)?
Worth itNot sureNot worth it
Reviews for Glucotrol
50%
-50% worse vs. Jardiance
32%
-32% worse vs. Jardiance
19%
+19% better vs. Jardiance
332 reviews
Have you used Glucotrol XL (glipizide)?
Worth itNot sureNot worth it
Side effects
JardianceGlucotrol
  • Low blood sugar 3%
  • Urinary tract infection 1%
  • Yeast infection in women 3%
  • Elevated cholesterol levels 1%
  • Increased urination 2%
  • Yeast infection in men 3%
  • Nausea 1%
More Jardiance side effects »
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Low blood sugar 3%
  • Constipation 3%
  • Nausea 3%
  • Headache 2%
More Glucotrol side effects »
How it works
JardianceGlucotrol
Jardiance (empagliflozin) is an anti-diabetes medication. It passes the sugar from your blood through your urine.Glucotrol XL (glipizide) stimulates your body to release insulin and lower blood sugar.
Type of medication
JardianceGlucotrol
Prescription onlyPrescription only
Available as
JardianceGlucotrol
  • Pill
  • Pill
  • Extended release pill
Used for
JardianceGlucotrol
Risk factors for serious side effects
JardianceGlucotrol
  • Over age 65
  • Kidney disease
  • Taking blood pressure medications
  • Dehydration
  • Poor baseline kidney function
Detailed Jardiance (empagliflozin) risks & warnings »
  • Skipping meals or having inconsistent meal times
  • Drinking alcohol
  • Using other blood sugar-lowering medicine
  • People age 60 or older
  • Those with kidney and/or liver problems
Detailed Glucotrol XL (glipizide) risks & warnings »
Pregnancy
Alcohol
JardianceGlucotrol
No alcohol related info.
  • Avoid drinking alcohol while taking Glucotrol XL (glipizide).
Food
JardianceGlucotrol
  • Take once a day in the morning with or without food.
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
Kidneys and liver
JardianceGlucotrol
  • Jardiance (empagliflozin) can cause or worsen kidney problems. Make sure to stay properly hydrated. Get blood test for kidney function before starting Jardiance (empagliflozin), a few weeks after starting, and regularly thereafter.
  • People with kidney and/or liver problems take a longer time to get rid of Glucotrol XL (glipizide) from their body. They are more sensitive to the effects of low blood sugar that include symptoms such as fast heartbeat, sweating, pale skin, shakiness, confusion and irritability. They need to make sure to carry with them some form of sugar such as hard candies or glucose tablets at all times while they are on this medicine.
  • Can be used in those with kidney problems.
Pain
JardianceGlucotrol
  • Let your doctor know of any constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting.
No pain related info.
Weight
JardianceGlucotrol
  • Can cause weight loss.
  • Can cause mild weight gain of 2 to 3 pounds on average.
Upsides and benefits
JardianceGlucotrol
  • Lowers A1c (average blood sugar over time) levels up to 1%.
  • Can prevent death from heart attack, stroke, or heart failure if you have pre-existing heart disease.
  • Can be easily taken orally as a pill.
  • Can cause weight loss.
  • Not likely to cause hypoglycemia or very low blood sugar.
  • Lowers A1c levels by 1-2%. (A1c is a test that measures your average blood sugars over the past 3 months).
  • Glucotrol XL (glipizide) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Can be used in those with kidney problems.
  • Available as a generic form and is relatively cheap.
Downsides and risks
JardianceGlucotrol
  • More expensive since it's available as brand name only.
  • Can cause dehydration.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • While taking Glucotrol XL (glipizide), your blood sugars should be checked 2 to 5 times a week, but less often once you are on a stable dose.
  • Can cause mild weight gain of 2 to 3 pounds on average.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
Tips from our pharmacists for people taking the medication
JardianceGlucotrol
  • Take once a day in the morning with or without food.
  • You urinate more often so make sure to stay properly hydrated.
  • Can lower blood pressure.
  • Increases the chances of yeast or urinary tract infection, so practice good hygiene.
  • Check blood sugar and blood pressure regularly.
  • Let your doctor know of any constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting.
  • Take the medicine 30 minutes before eating, usually before your first big meal of the day.
  • Avoid drinking alcohol while taking Glucotrol XL (glipizide).
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
  • Check your blood sugar regularly.
  • Glucotrol XL (glipizide) can cause dizziness so avoid activities that require coordination until you know how your body can handle the medicine.
Learn more
More about JardianceSide effectsAlternativesFDA package insert
Have you used Jardiance (empagliflozin)?
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More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Glucotrol XL (glipizide)?
Worth itNot sureNot worth it