Compare Jardiance vs. Glucovance

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Jardiance (empagliflozin)

Prescription only

Glyburide / Metformin

Prescription only
Lowers blood sugar.

Jardiance (empagliflozin) lowers blood sugar for people with diabetes, but can increase the chance of a yeast infection.

Lowers blood sugar.

Glyburide / Metformin is an effective combination medicine for lowering blood sugar, but it is likely to cause diarrhea in the first few weeks.

Upsides
  • Lowers A1c (average blood sugar over time) levels up to 1%.
  • Can prevent death from heart attack, stroke, or heart failure if you have pre-existing heart disease.
  • Can be easily taken orally as a pill.
  • Can cause weight loss.
  • Not likely to cause hypoglycemia or very low blood sugar.
  • Glyburide / Metformin effectively lowers blood sugar levels more so than if each of the individual medicines it contains are taken alone.
  • Protects your organs and blood vessels from the harmful effects of high blood sugar levels.
  • Can potentially lower your "bad cholesterol" levels.
  • Glyburide / Metformin is available in a generic form and is cheaper than many other combination diabetes medicines.
Downsides
  • More expensive since it's available as brand name only.
  • Can cause dehydration.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • Glyburide / Metformin is likely to cause nausea, stomach upset, or diarrhea in the first few weeks.
  • Not a good treatment option for those with kidney and/or liver problems.
  • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
  • Can cause some weight gain.
Used for
Dosage forms
  • Pill
  • Pill
Price
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$448.76
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Lowest price near you
$14.4
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Side effects
The Jardiance (empagliflozin) FDA package insert doesn’t have numbers about how common side effects are.
6possible side effects
  • Upper respiratory infection
    17%
  • Diarrhea
    17%
  • Headache
    9%
  • Nausea/vomiting
    8%
  • Stomach pain
    7%
  • Dizziness
    6%
See more detailed side effects
Risks and warnings
  • Low blood pressure

    Over age 65

    ...and 2 more risk factors

  • Worsening kidney function

    Dehydration

    ...and 2 more risk factors

  • Too much acid in the blood

    Type 1 diabetes

    ...and 1 more risk factors

See more detailed risks and warnings
  • Lactic acid build up in blood

    History of kidney problems

    ...and 5 more risk factors

  • Low blood sugar

    Skipping meals or having inconsistent meal times

    ...and 4 more risk factors

  • Severe allergic reaction

    History of allergy to sulfa-containing medicine

  • Breakdown of red blood cells

    People with G6PD deficiency

See more detailed risks and warnings