Compare Jardiance vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Jardiance
(empagliflozin)

Diabeta
(glyburide)

Lowers blood sugar. Jardiance (empagliflozin) lowers blood sugar for people with diabetes, but can increase the chance of a yeast infection.Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.
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Coupons for glyburide
Best available price for 60 (5mg) tablets of glyburide
Reviews & ratings
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Have you used Jardiance (empagliflozin)?
Worth itNot sureNot worth it
Reviews for glyburide
45%
-45% worse vs. Jardiance
34%
-34% worse vs. Jardiance
21%
+21% better vs. Jardiance
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Side effects
Jardianceglyburide
  • Low blood sugar 3%
  • Urinary tract infection 1%
  • Yeast infection in women 3%
  • Elevated cholesterol levels 1%
  • Increased urination 2%
  • Yeast infection in men 3%
  • Nausea 1%
More Jardiance side effects »
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
How it works
Jardianceglyburide
Jardiance (empagliflozin) is an anti-diabetes medication. It passes the sugar from your blood through your urine.Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.
Type of medication
Jardianceglyburide
Prescription onlyPrescription only
Available as
Jardianceglyburide
  • Pill
  • Pill
Used for
Jardianceglyburide
Risk factors for serious side effects
Jardianceglyburide
  • Over age 65
  • Kidney disease
  • Taking blood pressure medications
  • Dehydration
  • Poor baseline kidney function
Detailed Jardiance (empagliflozin) risks & warnings »
  • Over age 65
  • Kidney problems
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
Detailed Diabeta (glyburide) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
Jardianceglyburide
No alcohol related info.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
Food
Jardianceglyburide
  • Take once a day in the morning with or without food.
  • Eat well-balanced meals to avoid low blood sugar.
Kidneys and liver
Jardianceglyburide
  • Jardiance (empagliflozin) can cause or worsen kidney problems. Make sure to stay properly hydrated. Get blood test for kidney function before starting Jardiance (empagliflozin), a few weeks after starting, and regularly thereafter.
  • Not ideal for elderly or those with poor kidney function.
Pain
Jardianceglyburide
  • Let your doctor know of any constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting.
No pain related info.
Weight
Jardianceglyburide
  • Can cause weight loss.
  • Can cause weight gain, dizziness, or stomach upset.
  • Can cause weight gain (about 2 to 3 pounds).
Upsides and benefits
Jardianceglyburide
  • Lowers A1c (average blood sugar over time) levels up to 1%.
  • Can prevent death from heart attack, stroke, or heart failure if you have pre-existing heart disease.
  • Can be easily taken orally as a pill.
  • Can cause weight loss.
  • Not likely to cause hypoglycemia or very low blood sugar.
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
Downsides and risks
Jardianceglyburide
  • More expensive since it's available as brand name only.
  • Can cause dehydration.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
Tips from our pharmacists for people taking the medication
Jardianceglyburide
  • Take once a day in the morning with or without food.
  • You urinate more often so make sure to stay properly hydrated.
  • Can lower blood pressure.
  • Increases the chances of yeast or urinary tract infection, so practice good hygiene.
  • Check blood sugar and blood pressure regularly.
  • Let your doctor know of any constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting.
  • Check your blood sugar regularly.
  • Eat well-balanced meals to avoid low blood sugar.
  • Works best if you take it 30 minutes before first main meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
Learn more
More about JardianceSide effectsAlternativesFDA package insert
Have you used Jardiance (empagliflozin)?
Worth itNot sureNot worth it
More about glyburideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it