Compare Jardiance vs. Invokamet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Jardiance
(empagliflozin)

Invokamet
(canagliflozin / metformin)

Lowers blood sugar. Jardiance (empagliflozin) lowers blood sugar for people with diabetes, but can increase the chance of a yeast infection.Lowers blood sugar. Invokamet (canagliflozin / metformin) is a combination of 2 medicines that can lower your blood sugars, but it still has to be taken twice daily.
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Reviews & ratings
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Have you used Jardiance (empagliflozin)?
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Have you used Invokamet (canagliflozin / metformin)?
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Side effects
JardianceInvokamet
  • Low blood sugar 3%
  • Urinary tract infection 1%
  • Yeast infection in women 3%
  • Elevated cholesterol levels 1%
  • Increased urination 2%
  • Yeast infection in men 3%
  • Nausea 1%
More Jardiance side effects »
  • Yeast infection in women 8%
  • Urinary tract infections 2%
  • Increased urination 4%
  • Yeast infection in men 3%
  • Thirst 3%
  • Vaginal itching 2%
  • Constipation 1%
  • Abdominal pain 1%
More Invokamet side effects »
How it works
JardianceInvokamet
Jardiance (empagliflozin) is an anti-diabetes medication. It passes the sugar from your blood through your urine.Invokamet (canagliflozin / metformin) is a combination of anti-diabetes medicines. Metformin lowers blood sugar by enhancing your body's response to insulin, while canagliflozin increases your body's secretion of sugar through the urine.
Type of medication
JardianceInvokamet
Prescription onlyPrescription only
Available as
JardianceInvokamet
  • Pill
  • Pill
Used for
JardianceInvokamet
Risk factors for serious side effects
JardianceInvokamet
  • Over age 65
  • Kidney disease
  • Taking blood pressure medications
  • Dehydration
  • Poor baseline kidney function
Detailed Jardiance (empagliflozin) risks & warnings »
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Contrast dye for procedure
  • Surgery
Detailed Invokamet (canagliflozin / metformin) risks & warnings »
Pregnancy
Food
JardianceInvokamet
  • Take once a day in the morning with or without food.
  • Take with meals to avoid an upset stomach.
Kidneys and liver
JardianceInvokamet
  • Jardiance (empagliflozin) can cause or worsen kidney problems. Make sure to stay properly hydrated. Get blood test for kidney function before starting Jardiance (empagliflozin), a few weeks after starting, and regularly thereafter.
  • Not a good option if you have worsening kidney function such as those age 65 years and up.
Pain
JardianceInvokamet
  • Let your doctor know of any constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting.
  • Invokamet (canagliflozin / metformin) can, in very rare cases, hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or are taking medicines for blood pressure or pain like NSAIDs. Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Invokamet (canagliflozin / metformin).
Weight
JardianceInvokamet
  • Can cause weight loss.
  • Does not cause weight gain unlike other anti-diabetic medicines.
Upsides and benefits
JardianceInvokamet
  • Lowers A1c (average blood sugar over time) levels up to 1%.
  • Can prevent death from heart attack, stroke, or heart failure if you have pre-existing heart disease.
  • Can be easily taken orally as a pill.
  • Can cause weight loss.
  • Not likely to cause hypoglycemia or very low blood sugar.
  • Combines 2 effective anti-diabetes medicines into one pill so you don't have to take them separately.
  • Does not cause weight gain unlike other anti-diabetic medicines.
  • Not as likely to cause hypoglycemia (low blood sugar)
Downsides and risks
JardianceInvokamet
  • More expensive since it's available as brand name only.
  • Can cause dehydration.
  • Not a good option if you have worsening kidney function such as those age 65 years and up.
  • May cause increased urination.
  • More likely to cause broken bones and yeast and urinary tract infections.
Tips from our pharmacists for people taking the medication
JardianceInvokamet
  • Take once a day in the morning with or without food.
  • You urinate more often so make sure to stay properly hydrated.
  • Can lower blood pressure.
  • Increases the chances of yeast or urinary tract infection, so practice good hygiene.
  • Check blood sugar and blood pressure regularly.
  • Let your doctor know of any constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting.
  • Take with meals to avoid an upset stomach.
  • Practice good hygiene to prevent yeast infections.
  • Can cause dehydration so be sure to drink plenty of fluids.
  • Make sure to continue a healthy diet and lifetyle.
Learn more
More about JardianceSide effectsAlternativesFDA package insert
Have you used Jardiance (empagliflozin)?
Worth itNot sureNot worth it
More about InvokametSide effectsAlternativesFDA package insert
Have you used Invokamet (canagliflozin / metformin)?
Worth itNot sureNot worth it