Compare Jardiance vs. Invokana

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Jardiance
(empagliflozin)

Invokana
(canagliflozin)

Lowers blood sugar. Jardiance (empagliflozin) lowers blood sugar for people with diabetes, but can increase the chance of a yeast infection.Lowers blood sugar. Invokana (canagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.
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Coupons for Invokana
Best available price for 30 (300mg) tablets of invokana
Reviews & ratings
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Have you used Jardiance (empagliflozin)?
Worth itNot sureNot worth it
Reviews for Invokana
67%
-67% worse vs. Jardiance
56%
-56% worse vs. Jardiance
19%
+19% better vs. Jardiance
Have you used Invokana (canagliflozin)?
Worth itNot sureNot worth it
Side effects
JardianceInvokana
  • Low blood sugar 3%
  • Urinary tract infection 1%
  • Yeast infection in women 3%
  • Elevated cholesterol levels 1%
  • Increased urination 2%
  • Yeast infection in men 3%
  • Nausea 1%
More Jardiance side effects »
  • Yeast infection in women 8%
  • Urinary tract infections 2%
  • Increased urination 4%
  • Yeast infection in men 3%
  • Thirst 3%
  • Vaginal itching 2%
  • Constipation 1%
  • Abdominal pain 1%
More Invokana side effects »
How it works
JardianceInvokana
Jardiance (empagliflozin) is an anti-diabetes medication. It passes the sugar from your blood through your urine.Invokana (canagliflozin) is an anti-diabetes medication. It lowers blood sugar by causing your body to get rid of sugar in your urine.
Type of medication
JardianceInvokana
Prescription onlyPrescription only
Available as
JardianceInvokana
  • Pill
  • Pill
Used for
JardianceInvokana
Risk factors for serious side effects
JardianceInvokana
  • Over age 65
  • Kidney disease
  • Taking blood pressure medications
  • Dehydration
  • Poor baseline kidney function
Detailed Jardiance (empagliflozin) risks & warnings »
  • History of amputations 
  • Peripheral vascular disease (narrowed blood vessels)
  • Nerve problems
  • Diabetic foot ulcers 
  • History of kidney damage
Detailed Invokana (canagliflozin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
JardianceInvokana
No alcohol related info.
  • Avoid if you are a heavy drinker of alcohol.
Food
JardianceInvokana
  • Take once a day in the morning with or without food.
  • Take once daily before your first meal of the day.
  • You only have to take Invokana (canagliflozin) once a day before meals.
Kidneys and liver
JardianceInvokana
  • Jardiance (empagliflozin) can cause or worsen kidney problems. Make sure to stay properly hydrated. Get blood test for kidney function before starting Jardiance (empagliflozin), a few weeks after starting, and regularly thereafter.
  • Not for people with severe kidney problems.
Pain
JardianceInvokana
  • Let your doctor know of any constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting.
  • Rarely, Invokana (canagliflozin) can hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or take certain medicines for blood pressure or anti-inflammatories (NSAIDs). Invokana (canagliflozin) can also lower your blood pressure since it makes you urinate more. Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Invokana (canagliflozin). Make sure to stay hydrated to prevent low blood pressure and kidney problems.
Weight
JardianceInvokana
  • Can cause weight loss.
No weight related info.
Upsides and benefits
JardianceInvokana
  • Lowers A1c (average blood sugar over time) levels up to 1%.
  • Can prevent death from heart attack, stroke, or heart failure if you have pre-existing heart disease.
  • Can be easily taken orally as a pill.
  • Can cause weight loss.
  • Not likely to cause hypoglycemia or very low blood sugar.
  • Lowers A1C (blood sugar) levels by 1%.
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Less likely to cause low blood sugar than other diabetes medicines.
  • Also available as a combination drug with metformin (Invokamet).
Downsides and risks
JardianceInvokana
  • More expensive since it's available as brand name only.
  • Can cause dehydration.
  • You're more likely to have broken bones, yeast infections and urinary tract infections with Invokana (canagliflozin).
  • There's a rare but serious risk of leg and foot amputations with Invokana (canagliflozin). Talk to your doctor if you develop new pain or infections in your feet.
  • Not for people with severe kidney problems.
  • Can raise your cholesterol.
  • Avoid if you are a heavy drinker of alcohol.
Tips from our pharmacists for people taking the medication
JardianceInvokana
  • Take once a day in the morning with or without food.
  • You urinate more often so make sure to stay properly hydrated.
  • Can lower blood pressure.
  • Increases the chances of yeast or urinary tract infection, so practice good hygiene.
  • Check blood sugar and blood pressure regularly.
  • Let your doctor know of any constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting.
  • Take once daily before your first meal of the day.
  • Invokana (canagliflozin) can cause you to urinate more, so be sure to stay hydrated.
  • Can cause genital yeast infections in females and males.
  • Can cause urinary tract infections (UTI).
  • Can cause low blood sugar, so make sure to check your blood sugar if you don't feel well.
  • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Invokana (canagliflozin).
Learn more
More about JardianceSide effectsAlternativesFDA package insert
Have you used Jardiance (empagliflozin)?
Worth itNot sureNot worth it
More about InvokanaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Invokana (canagliflozin)?
Worth itNot sureNot worth it