Compare Jardiance vs. metformin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Jardiance (empagliflozin)

Prescription only

Glucophage (metformin)

Prescription only
Lowers blood sugar.

Jardiance (empagliflozin) lowers blood sugar for people with diabetes, but can increase the chance of a yeast infection.

Lowers blood sugar.

Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.

5.0/ 7 average rating with 938 reviewsformetformin
Upsides
  • Lowers A1c (average blood sugar over time) levels up to 1%.
  • Can prevent death from heart attack, stroke, or heart failure if you have pre-existing heart disease.
  • Can be easily taken orally as a pill.
  • Can cause weight loss.
  • Not likely to cause hypoglycemia or very low blood sugar.
  • Improves sugar control and lowers A1c levels as much as 2%.
  • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
  • Doesn't cause weight gain.
  • Rarely causes low blood sugar.
Downsides
  • More expensive since it's available as brand name only.
  • Can cause dehydration.
  • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release pill
  • Liquid
Price
Lowest price near you
$448.76
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Lowest price near you
$4
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Reviews
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938 
65%
think this treatment is worth it
46%
think this treatment works well
16%
think this treatment is a hassle

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Side effects
The Jardiance (empagliflozin) FDA package insert doesn’t have numbers about how common side effects are.
7possible side effects
  • Diarrhea
    53%
  • Nausea/vomiting
    26%
  • Gas
    12%
  • Weakness
    9%
  • Indigestion
    7%
  • Stomach pain
    6%
  • Headache
    6%
See more detailed side effects
Risks and warnings
  • Low blood pressure

    Over age 65

    ...and 2 more risk factors

  • Worsening kidney function

    Dehydration

    ...and 2 more risk factors

  • Too much acid in the blood

    Type 1 diabetes

    ...and 1 more risk factors

See more detailed risks and warnings
  • Excess lactic acid in the blood

    Kidney problems

    ...and 5 more risk factors

See more detailed risks and warnings