Compare Jardiance vs. metformin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Jardiance
(empagliflozin)

Glucophage
(metformin)

Lowers blood sugar. Jardiance (empagliflozin) lowers blood sugar for people with diabetes, but can increase the chance of a yeast infection.Lowers blood sugar. Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.
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Best available price for 60 (500mg) tablets of metformin
Reviews & ratings
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Have you used Jardiance (empagliflozin)?
Worth itNot sureNot worth it
Reviews for metformin
65%
-65% worse vs. Jardiance
46%
-46% worse vs. Jardiance
16%
+16% better vs. Jardiance
938 reviews
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it
Side effects
Jardiancemetformin
  • Low blood sugar 3%
  • Urinary tract infection 1%
  • Yeast infection in women 3%
  • Elevated cholesterol levels 1%
  • Increased urination 2%
  • Yeast infection in men 3%
  • Nausea 1%
More Jardiance side effects »
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Gas 6%
  • Weakness 3%
  • Indigestion 3%
  • Stomach pain 1%
  • Headache 1%
More metformin side effects »
How it works
Jardiancemetformin
Jardiance (empagliflozin) is an anti-diabetes medication. It passes the sugar from your blood through your urine.Glucophage (metformin) is an anti-diabetic drug. It lowers the amount of sugar your body makes or absorbs, and allows your body use the existing insulin better.
Type of medication
Jardiancemetformin
Prescription onlyPrescription only
Available as
Jardiancemetformin
  • Pill
  • Pill
  • Extended release pill
  • Liquid
Used for
Jardiancemetformin
Risk factors for serious side effects
Jardiancemetformin
  • Over age 65
  • Kidney disease
  • Taking blood pressure medications
  • Dehydration
  • Poor baseline kidney function
Detailed Jardiance (empagliflozin) risks & warnings »
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Glucophage (metformin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
Jardiancemetformin
No alcohol related info.
  • Limit or avoid alcohol when taking this medicine.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
Food
Jardiancemetformin
  • Take once a day in the morning with or without food.
  • Always take it with food to lessen stomach upset.
Kidneys and liver
Jardiancemetformin
  • Jardiance (empagliflozin) can cause or worsen kidney problems. Make sure to stay properly hydrated. Get blood test for kidney function before starting Jardiance (empagliflozin), a few weeks after starting, and regularly thereafter.
  • Glucophage (metformin) can cause this rare life-threatening condition. Your doctor will check your kidneys and liver before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. You're more likely to get this if you already have kidney problems. Glucophage (metformin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
Pain
Jardiancemetformin
  • Let your doctor know of any constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting.
No pain related info.
Weight
Jardiancemetformin
  • Can cause weight loss.
  • Doesn't cause weight gain.
Upsides and benefits
Jardiancemetformin
  • Lowers A1c (average blood sugar over time) levels up to 1%.
  • Can prevent death from heart attack, stroke, or heart failure if you have pre-existing heart disease.
  • Can be easily taken orally as a pill.
  • Can cause weight loss.
  • Not likely to cause hypoglycemia or very low blood sugar.
  • Improves sugar control and lowers A1c levels as much as 2%.
  • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
  • Doesn't cause weight gain.
  • Rarely causes low blood sugar.
Downsides and risks
Jardiancemetformin
  • More expensive since it's available as brand name only.
  • Can cause dehydration.
  • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
Tips from our pharmacists for people taking the medication
Jardiancemetformin
  • Take once a day in the morning with or without food.
  • You urinate more often so make sure to stay properly hydrated.
  • Can lower blood pressure.
  • Increases the chances of yeast or urinary tract infection, so practice good hygiene.
  • Check blood sugar and blood pressure regularly.
  • Let your doctor know of any constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting.
  • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
  • Always take it with food to lessen stomach upset.
  • Stay hydrated.
  • Limit or avoid alcohol when taking this medicine.
  • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
  • Check your blood sugar regularly.
Learn more
More about JardianceSide effectsAlternativesFDA package insert
Have you used Jardiance (empagliflozin)?
Worth itNot sureNot worth it
More about metforminSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it