Compare Jardiance vs. Onglyza

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Jardiance
(empagliflozin)

Onglyza
(saxagliptin)

Lowers blood sugar. Jardiance (empagliflozin) lowers blood sugar for people with diabetes, but can increase the chance of a yeast infection.Lowers blood sugar. Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.
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Reviews & ratings
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Have you used Jardiance (empagliflozin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Onglyza (saxagliptin)?
Worth itNot sureNot worth it
Side effects
JardianceOnglyza
  • Low blood sugar 3%
  • Urinary tract infection 1%
  • Yeast infection in women 3%
  • Elevated cholesterol levels 1%
  • Increased urination 2%
  • Yeast infection in men 3%
  • Nausea 1%
More Jardiance side effects »
  • Urinary tract infection 1%
  • Headache 1%
  • Swelling in arms and legs 4%
  • Low blood sugar (hypoglycemia) 2%
  • Allergic reactions 2%
More Onglyza side effects »
How it works
JardianceOnglyza
Jardiance (empagliflozin) is an anti-diabetes medication. It passes the sugar from your blood through your urine.Onglyza (saxagliptin) is an anti-diabetic drug. It lowers your blood sugar by enhancing your body's release of insulin.
Type of medication
JardianceOnglyza
Prescription onlyPrescription only
Available as
JardianceOnglyza
  • Pill
  • Pill
Used for
JardianceOnglyza
Risk factors for serious side effects
JardianceOnglyza
  • Over age 65
  • Kidney disease
  • Taking blood pressure medications
  • Dehydration
  • Poor baseline kidney function
Detailed Jardiance (empagliflozin) risks & warnings »
  • Alcoholism
  • Elevated triglycerides
  • History of pancreatitis
  • Gallstones
  • History of heart failure
Detailed Onglyza (saxagliptin) risks & warnings »
Pregnancy
Interactions
JardianceOnglyza
No interactions related info.
  • Certain drugs may interact with Onglyza (saxagliptin), let your doctor know all the medications you are currently taking and before starting Onglyza (saxagliptin).
Food
JardianceOnglyza
  • Take once a day in the morning with or without food.
No food related info.
Kidneys and liver
JardianceOnglyza
  • Jardiance (empagliflozin) can cause or worsen kidney problems. Make sure to stay properly hydrated. Get blood test for kidney function before starting Jardiance (empagliflozin), a few weeks after starting, and regularly thereafter.
  • May be a good option for those with bad liver function.
Pain
JardianceOnglyza
  • Let your doctor know of any constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting.
No pain related info.
Weight
JardianceOnglyza
  • Can cause weight loss.
  • Does not cause weight gain.
Upsides and benefits
JardianceOnglyza
  • Lowers A1c (average blood sugar over time) levels up to 1%.
  • Can prevent death from heart attack, stroke, or heart failure if you have pre-existing heart disease.
  • Can be easily taken orally as a pill.
  • Can cause weight loss.
  • Not likely to cause hypoglycemia or very low blood sugar.
  • DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
  • Does not cause weight gain.
  • May be a good option for those with bad liver function.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
Downsides and risks
JardianceOnglyza
  • More expensive since it's available as brand name only.
  • Can cause dehydration.
  • Typically not first-choice treatment for diabetes.
  • Only lowers A1C (average blood sugar over time) by ~0.5%.
  • Risk for heart failure has not been seen in other medicines that work just like it.
  • May be more expensive than other anti-diabetic medicines.
Tips from our pharmacists for people taking the medication
JardianceOnglyza
  • Take once a day in the morning with or without food.
  • You urinate more often so make sure to stay properly hydrated.
  • Can lower blood pressure.
  • Increases the chances of yeast or urinary tract infection, so practice good hygiene.
  • Check blood sugar and blood pressure regularly.
  • Let your doctor know of any constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting.
  • Is taken once daily.
  • Certain drugs may interact with Onglyza (saxagliptin), let your doctor know all the medications you are currently taking and before starting Onglyza (saxagliptin).
  • Stop taking Onglyza (saxagliptin) and see your doctor immediately if you experience severe stomach pain that does not go away, as this may indicate dangerous inflammation of the pancreas.
  • Maintain a consistent diet and exercise regimen to prevent low blood sugar or high blood sugar.
Learn more
More about JardianceSide effectsAlternativesFDA package insert
Have you used Jardiance (empagliflozin)?
Worth itNot sureNot worth it
More about OnglyzaSide effectsAlternativesFDA package insert
Have you used Onglyza (saxagliptin)?
Worth itNot sureNot worth it