Compare Jardiance vs. Onglyza

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Jardiance (empagliflozin)

Prescription only

Onglyza (saxagliptin)

Prescription only
Lowers blood sugar.

Jardiance (empagliflozin) lowers blood sugar for people with diabetes, but can increase the chance of a yeast infection.

Lowers blood sugar.

Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.

Upsides
  • Lowers A1c (average blood sugar over time) levels up to 1%.
  • Can prevent death from heart attack, stroke, or heart failure if you have pre-existing heart disease.
  • Can be easily taken orally as a pill.
  • Can cause weight loss.
  • Not likely to cause hypoglycemia or very low blood sugar.
  • DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
  • Does not cause weight gain.
  • May be a good option for those with bad liver function.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
Downsides
  • More expensive since it's available as brand name only.
  • Can cause dehydration.
  • Typically not first-choice treatment for diabetes.
  • Only lowers A1C (average blood sugar over time) by ~0.5%.
  • Risk for heart failure has not been seen in other medicines that work just like it.
  • May be more expensive than other anti-diabetic medicines.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$448.76
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Lowest price near you
$402.35
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Reviews
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Side effects
The Jardiance (empagliflozin) FDA package insert doesn’t have numbers about how common side effects are.
The Onglyza (saxagliptin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Low blood pressure

    Over age 65

    ...and 2 more risk factors

  • Worsening kidney function

    Dehydration

    ...and 2 more risk factors

  • Too much acid in the blood

    Type 1 diabetes

    ...and 1 more risk factors

See more detailed risks and warnings
  • inflammation of the pancreas

    Alcoholism

    ...and 3 more risk factors

  • Heart failure

    History of heart failure

    ...and 1 more risk factors

  • Low blood sugar (hypoglycemia)

    Alcohol

    ...and 3 more risk factors

See more detailed risks and warnings