Compare Kapvay vs. Provigil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Kapvay
(Clonidine)

Provigil
(Modafinil)

Treats ADHD and lowers blood pressure. Clonidine is a non-stimulant option to manage ADHD symptoms and behaviors, but it can lower your blood pressure.Improves alertness. Provigil (Modafinil) is effective in improving alertness, but it can interact with other medicines and shouldn't be used long-term.
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Reviews & ratings
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Reviews for Provigil (Modafinil)
78%
+28% vs. Kapvay (Clonidine)
70%
+20% vs. Kapvay (Clonidine)
4%
+21% vs. Kapvay (Clonidine)
Side effects
KapvayProvigil
  • Drowsiness 34%
  • Any side effect 19%
  • Fatigue 15%
  • Irritability 5%
  • Sleep difficulty 5%
  • Headache 4%
  • Dry mouth 4%
  • Upper abdominal pain 3%
  • Emotional disorder 3%
  • Dizziness 2%
More Kapvay side effects »
  • Headache 11%
  • Nausea 8%
  • Any side effect 5%
  • Nervousness 4%
  • Sleep difficulty 4%
  • Anxiety 4%
  • Loss of appetite 3%
  • Dry mouth 2%
  • Sore throat 2%
  • Chest pain 2%
More Provigil side effects »
How it works
KapvayProvigil
Clonidine is an alpha-2 agonist. Researchers don't know exactly how it works for ADHD. It works in the brain and lowers the activity of certain stress hormones, but it's not a stimulant like many ADHD medicines.Provigil (Modafinil) is a stimulant that helps you feel awake. Researchers don't know exactly how Provigil (Modafinil) works, but it probably affects chemicals (neurotransmitters) in the brain.
Type of medication
KapvayProvigil
Antihypertensive
Alpha agonist
Prescription only
StimulantPrescription only
Available as
KapvayProvigil
  • Extended release
  • Pill
Used for (click to learn more)
KapvayProvigil
Risk factors for serious side effects
KapvayProvigil
  • Sudden discontinuation of medicine
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 years or older
  • Using other medicine(s) that slows the heart
    Detailed Kapvay (Clonidine) risks & warnings »
    • Taking with alcohol
    • Taking other medicines that make you less alert
        • Current kidney problems
        • Current liver problems
        • History of heart problems
        • History of psychiatric disorder
        • History of bipolar disorder
        Detailed Provigil (Modafinil) risks & warnings »
        Pregnancy category
        KapvayProvigil
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.
        • Don't drink alcohol with Provigil (Modafinil).
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.
        • Not a good choice if you have liver or kidney problems.
        • Provigil (Modafinil) is broken down by the kidney and liver. If you have kidney or liver problems, you may need to use a lower dose to prevent more side effects.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        • Can cause drowsiness, headache, dizziness, and dry mouth.
        • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
        • Doesn't negatively affect daytime sleep.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        KapvayProvigil
        • Can be used alone or together with a stimulant-type medicine to treat ADHD.
        • In studies, it improved attention span and lowered hyperactivity and impulsivity in children and adolescents ages 6 to 17.
        • Also treats blood pressure and some nervous system and psychiatric conditions.
        • It's a non-amphetamine medicine that helps improve alertness.
        • Available in a generic version.
        • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
        • Doesn't negatively affect daytime sleep.
        Downsides and risks
        KapvayProvigil
        • Can lower blood pressure.
        • The pill form can make some people sleepy, dizzy, and have dry mouth.
        • You can't miss doses. Stopping Clonidine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
        • Provigil (Modafinil) can be habit-forming, so it's typically not used for long-term treatment.
        • Interacts with many other medications.
        • Taking Provigil (Modafinil) will make hormonal birth control less effective. You should definitely use additional forms of non-hormonal contraception.
        • Not a good choice if you have liver or kidney problems.
        Tips from our pharmacists for people taking the medication
        KapvayProvigil
        • Can cause drowsiness, headache, dizziness, and dry mouth.
        • For ADHD: Might take up to 2 weeks to see effects.
        • For high blood pressure: Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
        • If side effects don't go away, talk to your doctor about alternatives.
        • Don't stop taking this medicine suddenly.
        • Take Provigil (Modafinil) about an hour before you need to be fully alert.
        • Taking caffeine with Provigil (Modafinil) can cause you to feel nervous, shaky, and have a faster heartbeat. Try limiting your caffeine intake.
        • Until you know how Provigil (Modafinil) makes you feel, don't drive or perform any tasks that need you to be alert.
        • You can experience withdrawal symptoms if you suddenly stop taking Provigil (Modafinil). Talk to your doctor before making any changes.
        • Tell your doctor right away if you break out in a rash.
        • Don't drink alcohol with Provigil (Modafinil).
        Learn more
        More about KapvaySide effectsReviews & ratingsAlternativesFDA package insert
        More about ProvigilSide effectsReviews & ratingsAlternativesFDA package insert